SNRNP25 small nuclear ribonucleoprotein U11/U12 subunit 25 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SNRNP25provided by HGNC
Official Full Name: small nuclear ribonucleoprotein U11/U12 subunit 25provided by HGNC
Primary source: HGNC:HGNC:14161
See related: Ensembl:ENSG00000161981 AllianceGenome:HGNC:14161
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C16orf33
Summary: Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]
Expression: Ubiquitous expression in brain (RPKM 19.4), heart (RPKM 18.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (53828..57669)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (47364..51206)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (103828..107669)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas.
Title: Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD00252 (e-PCR)
- UniSTS:281366

ECD01032 (e-PCR)
- UniSTS:282140

D16S3332 (e-PCR)
- UniSTS:65082

ECD06052 (e-PCR)
- UniSTS:287114

ECD01733 (e-PCR)
- UniSTS:282834

REN94495 (e-PCR)
- UniSTS:419293

REN94496 (e-PCR)
- UniSTS:419294

REN94497 (e-PCR)
- UniSTS:419295

REN94498 (e-PCR)
- UniSTS:419296

REN94499 (e-PCR)
- UniSTS:419297

REN94500 (e-PCR)
- UniSTS:419298

REN94501 (e-PCR)
- UniSTS:419299

REN94502 (e-PCR)
- UniSTS:419300

REN94503 (e-PCR)
- UniSTS:419301

REN94504 (e-PCR)
- UniSTS:419302

REN94505 (e-PCR)
- UniSTS:419303

REN94506 (e-PCR)
- UniSTS:419304

REN94507 (e-PCR)
- UniSTS:419305

REN94508 (e-PCR)
- UniSTS:419306

REN94509 (e-PCR)
- UniSTS:419307

REN94510 (e-PCR)
- UniSTS:419308

REN94511 (e-PCR)
- UniSTS:419309

REN94512 (e-PCR)
- UniSTS:419310

REN94513 (e-PCR)
- UniSTS:419311

REN94514 (e-PCR)
- UniSTS:419312

REN94515 (e-PCR)
- UniSTS:419313

REN94516 (e-PCR)
- UniSTS:419314

REN94517 (e-PCR)
- UniSTS:419315

REN94518 (e-PCR)
- UniSTS:419316

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U12-type spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U12-type spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Names: U11/U12 snRNP 25 kDa protein; U11/U12 snRNP 25K; minus-99 protein; small nuclear ribonucleoprotein 25kDa (U11/U12); small nuclear ribonucleoprotein, U11/U12 25kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_017004.2 RefSeqGene

Range

5002..8843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_024571.4 → NP_078847.2 U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Status: REVIEWED

Source sequence(s)

Z69719

Consensus CDS

CCDS10396.2

UniProtKB/TrEMBL

Q4TT61

Related

ENSP00000293861.3, ENST00000293861.8

Conserved Domains (1) summary

cd17058
Location:31 → 119

Ubl_SNRNP25; ubiquitin-like (Ubl) domain found in small nuclear ribonucleoprotein U11/U12 subunit 25 (SNRNP25) and similar proteins