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    HSP90AB4P heat shock protein 90 alpha family class B member 4, pseudogene [ Homo sapiens (human) ]

    Gene ID: 664618, updated on 14-Nov-2024

    Summary

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    Official Symbol
    HSP90AB4Pprovided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class B member 4, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:32538
    See related
    AllianceGenome:HGNC:32538
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP90Bd
    Summary
    Predicted to enable ATP binding activity; disordered domain specific binding activity; and unfolded protein binding activity. Predicted to be involved in cellular response to heat; protein folding; and protein stabilization. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HSP90AB4P in Genome Data Viewer
    Location:
    15q21.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (58690473..58693607, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (56492468..56495602, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (58982672..58985806, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 10 Neighboring gene high mobility group box 1 pseudogene 51 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:58978446-58978628 Neighboring gene G protein subunit gamma 10 pseudogene Neighboring gene RN7SK pseudogene 95 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:59041039-59041674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9478 Neighboring gene ATP synthase membrane subunit g pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. Chen B, et al. Genomics, 2005 Dec. PMID 16269234
    2. SUMO targets the APC/C to regulate transition from metaphase to anaphase. Eifler K, et al. Nat Commun, 2018 Mar 16. PMID 29549242, Free PMC Article
    3. A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. Cao Y, et al. EMBO J, 2023 Jul 3. PMID 36896912, Free PMC Article
    4. circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma. Li X, et al. Cancer Res, 2023 May 2. PMID 36811957, Free PMC Article
    5. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. Cloutier P, et al. PLoS Genet, 2013. PMID 23349634, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • heat shock protein 90Bd
    • heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene
    • heat shock protein 90kDa alpha family class B member 4, pseudogene

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_073415.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091046

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      58690473..58693607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      56492468..56495602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_002927.1: Suppressed sequence

      Description
      NR_002927.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q58FF6.1 GenPept UniProtKB/Swiss-Prot:Q58FF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials