DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DCAF4L1provided by HGNC
Official Full Name: DDB1 and CUL4 associated factor 4 like 1provided by HGNC
Primary source: HGNC:HGNC:27723
See related: Ensembl:ENSG00000182308 AllianceGenome:HGNC:27723
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WDR21B
Summary: Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 4p13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (41981756..41986465)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (41955575..41960286)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (41983773..41988482)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DDB1- and CUL4-associated factor 4-like protein 1

Names: WD repeat domain 21B; WD repeat-containing protein 21B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029955.4 → NP_001025126.2 DDB1- and CUL4-associated factor 4-like protein 1

See identical proteins and their annotated locations for NP_001025126.2

Status: VALIDATED

Source sequence(s)

AC106052, BC052943, BC104224, DB100231

Consensus CDS

CCDS33978.1

UniProtKB/Swiss-Prot

B3KVI3, Q3SXM0, Q3ZCW8, Q499Y5, Q9UFI0

Related

ENSP00000327796.5, ENST00000333141.7

Conserved Domains (2) summary

sd00039
Location:185 → 220

7WD40; WD40 repeat [structural motif]

cl25539
Location:210 → 368

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...