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    MLDHR mitochondrial lactate dehydrogenase regulator [ Homo sapiens (human) ]

    Gene ID: 133834869, updated on 4-Jan-2025

    Summary

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    Official Symbol
    MLDHRprovided by HGNC
    Official Full Name
    mitochondrial lactate dehydrogenase regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:55481
    See related
    MIM:620760; AllianceGenome:HGNC:55481
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MP31; PTENURF
    Summary
    Enables L-lactate dehydrogenase inhibitor activity. Involved in negative regulation of oxidative phosphorylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    not in current annotation release
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    Genomic context

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    See MLDHR in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    1

    Genomic regions, transcripts, and products

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    Genome Annotation Status: not in current annotation release

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism. Huang N, et al. Cell Metab, 2021 Jan 5. PMID 33406399

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PTEN upstream open reading frame MP31
    Names
    micropeptide 31 amino acids

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433720.1 → NP_001420649.1  PTEN upstream open reading frame MP31

      Status: VALIDATED

      Source sequence(s)
      AC063965
      UniProtKB/Swiss-Prot
      C0HLV8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HLV8.1 GenPept UniProtKB/Swiss-Prot:C0HLV8

    Gene LinkOut

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    Molecular Biology Databases