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    CKAP4 cytoskeleton associated protein 4 [ Homo sapiens (human) ]

    Gene ID: 10970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CKAP4provided by HGNC
    Official Full Name
    cytoskeleton associated protein 4provided by HGNC
    Primary source
    HGNC:HGNC:16991
    See related
    Ensembl:ENSG00000136026 MIM:618595; AllianceGenome:HGNC:16991
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p63; CLIMP63; CLIMP-63; ERGIC-63
    Summary
    Enables RNA binding activity. Located in lipid droplet and rough endoplasmic reticulum. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 41.9), placenta (RPKM 30.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CKAP4 in Genome Data Viewer
    Location:
    12q23.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (106237881..106248020, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (106200876..106211009, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (106631659..106641798, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NUAK family kinase 1 Neighboring gene uncharacterized LOC124903007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106523693-106524442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106524443-106525192 Neighboring gene Sharpr-MPRA regulatory region 11062 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:106526214-106527056 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527057-106527900 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:106527901-106528743 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106531161-106531662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:106534054-106534673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106541977-106542476 Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106581756-106582590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:106605939-106606439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4815 Neighboring gene uncharacterized LOC124903008 Neighboring gene RNA, U7 small nuclear 94 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Antiproliferative factor (APF) binds specifically to sites within the cytoskeleton-associated protein 4 (CKAP4) extracellular domain. Chavda B, et al. BMC Biochem, 2017 Sep 11. PMID 28893174, Free PMC Article
    2. The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Rufini S, et al. Biochem Pharmacol, 2011 Nov 15. PMID 21820419
    3. Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder carcinoma cells. Shahjee HM, et al. J Exp Clin Cancer Res, 2010 Dec 10. PMID 21143984, Free PMC Article
    4. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology. Clements SE, et al. Br J Dermatol, 2012 Jul. PMID 22329826
    5. Surfactant protein A blocks recognition of Pseudomonas aeruginosa by CKAP4/P63 on airway epithelial cells. Barbier M, et al. J Infect Dis, 2012 Dec 1. PMID 22966120

    See all (262) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The clinical significance and diagnostic value of serum Dickkopf1 and CKAP4 levels in patients with gastric cancer: a prospective study.
      Title: The clinical significance and diagnostic value of serum Dickkopf1 and CKAP4 levels in patients with gastric cancer: a prospective study.
    2. Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma.
      Title: Expression of cytoskeleton-associated protein 4 is associated with poor prognosis and metastasis in nasopharyngeal carcinoma.
    3. Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway.
      Title: Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway.
    4. Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway.
      Title: Plasmalemma vesicle-associated protein promotes angiogenesis in cholangiocarcinoma via the DKK1/CKAP4/PI3K signaling pathway.
    5. DKK1 activates noncanonical NF-kappaB signaling via IL-6-induced CKAP4 receptor in multiple myeloma.
      Title: DKK1 activates noncanonical NF-κB signaling via IL-6-induced CKAP4 receptor in multiple myeloma.
    6. Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
      Title: Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.
    7. The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.
      Title: The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma.
    8. p63 overexpression in the epidermis of spiny keratoderma.
      Title: p63 overexpression in the epidermis of spiny keratoderma.
    9. Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.
      Title: Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6.
    10. CKAP4 was secreted with small extracellular vesicles (SEVs) from pancreatic ductal adenocarcinoma (PDAC) cells, and the SEVs exhibited the characteristics of exosomes. The secretion of CKAP4-containing exosomes was mediated by DKK1-dependent endocytosis routes and required exosome biogenesis molecules. The serum CKAP4 levels were higher in patients with PDAC than healthy control individuals.
      Title: CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with cytoskeleton-associated protein 4 (CKAP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with cytoskeleton-associated protein 4 (CKAP4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC99554

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in lamellar body TAS
    Traceable Author Statement
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in rough endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cytoskeleton-associated protein 4
    Names
    63 kDa membrane protein
    63-kDa cytoskeleton-linking membrane protein
    transmembrane protein (63kD), endoplasmic reticulum/Golgi intermediate compartment
    type-II transmembrane protein p63

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006825.4 → NP_006816.2  cytoskeleton-associated protein 4

      See identical proteins and their annotated locations for NP_006816.2

      Status: VALIDATED

      Source sequence(s)
      AC079174, X69910
      Consensus CDS
      CCDS9103.1
      UniProtKB/Swiss-Prot
      Q07065, Q504S5, Q53ES6
      UniProtKB/TrEMBL
      B3KVX6
      Related
      ENSP00000367265.4, ENST00000378026.5
      Conserved Domains (2) summary
      TIGR00344
      Location:487 → 560
      alaS; alanine--tRNA ligase
      TIGR02168
      Location:149 → 459
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      106237881..106248020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      106200876..106211009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07065.2 GenPept UniProtKB/Swiss-Prot:Q07065

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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