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    CERS4 ceramide synthase 4 [ Homo sapiens (human) ]

    Gene ID: 79603, updated on 10-Dec-2024

    Summary

    Official Symbol
    CERS4provided by HGNC
    Official Full Name
    ceramide synthase 4provided by HGNC
    Primary source
    HGNC:HGNC:23747
    See related
    Ensembl:ENSG00000090661 MIM:615334; AllianceGenome:HGNC:23747
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Trh1; LASS4
    Summary
    Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.9), prostate (RPKM 10.3) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CERS4 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (8209370..8262421)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (8210805..8263817)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8274254..8327305)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3327 silencer Neighboring gene fibrillin 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8175802-8176302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8180417-8180917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8183744-8184561 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8185348-8185938 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8185939-8186529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8193691-8194192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8206295-8206796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8208101-8208645 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8211691-8212662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8212663-8213633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10012 Neighboring gene Sharpr-MPRA regulatory region 3488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8226075-8226576 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8228221-8229026 Neighboring gene ALG11, alpha-1,2-mannosyltransferase pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8260104-8260957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8260958-8261810 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8268618-8269588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8280063-8280564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8285012-8285518 Neighboring gene uncharacterized LOC107985282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13910 Neighboring gene MPRA-validated peak3333 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8368800-8369366 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372005-8372745 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8372746-8373485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8373541-8374070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8376825-8377427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8380680-8381486 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8384379-8385346 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:8385347-8386314 and GRCh37_chr19:8386315-8387282 Neighboring gene CD320 molecule Neighboring gene NADH:ubiquinone oxidoreductase subunit A7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12089

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sphingosine N-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sphingosine N-acyltransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ceramide synthase 4
    Names
    LAG1 homolog, ceramide synthase 4
    LAG1 longevity assurance homolog 4
    sphingosine N-acyltransferase CERS4
    NP_078828.2
    XP_011526592.1
    XP_011526593.1
    XP_016882793.1
    XP_016882794.1
    XP_047295389.1
    XP_047295390.1
    XP_047295391.1
    XP_047295392.1
    XP_047295393.1
    XP_047295394.1
    XP_047295395.1
    XP_054178119.1
    XP_054178120.1
    XP_054178121.1
    XP_054178122.1
    XP_054178123.1
    XP_054178124.1
    XP_054178125.1
    XP_054178126.1
    XP_054178127.1
    XP_054178128.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024552.3NP_078828.2  ceramide synthase 4

      See identical proteins and their annotated locations for NP_078828.2

      Status: VALIDATED

      Source sequence(s)
      AC022146, AK222621, BC009828, DA381485
      Consensus CDS
      CCDS12197.1
      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
      Related
      ENSP00000251363.5, ENST00000251363.10
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      8209370..8262421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027304.2XP_016882793.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    2. XM_047439435.1XP_047295391.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
      Related
      ENST00000595722.5
    3. XM_047439433.1XP_047295389.1  ceramide synthase 4 isoform X2

      UniProtKB/TrEMBL
      Q53HF9
    4. XM_011528290.3XP_011526592.1  ceramide synthase 4 isoform X1

      See identical proteins and their annotated locations for XP_011526592.1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    5. XM_017027305.2XP_016882794.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
      Related
      ENSP00000453509.1, ENST00000559450.6
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    6. XM_047439437.1XP_047295393.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    7. XM_047439434.1XP_047295390.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    8. XM_047439436.1XP_047295392.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    9. XM_011528291.3XP_011526593.1  ceramide synthase 4 isoform X1

      See identical proteins and their annotated locations for XP_011526593.1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
      Conserved Domains (2) summary
      smart00724
      Location:131332
      TLC; TRAM, LAG1 and CLN8 homology domains
      cd00086
      Location:71128
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    10. XM_047439438.1XP_047295394.1  ceramide synthase 4 isoform X3

    11. XM_047439439.1XP_047295395.1  ceramide synthase 4 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      8210805..8263817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322146.1XP_054178121.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    2. XM_054322150.1XP_054178125.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    3. XM_054322145.1XP_054178120.1  ceramide synthase 4 isoform X2

      UniProtKB/TrEMBL
      Q53HF9
    4. XM_054322144.1XP_054178119.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    5. XM_054322148.1XP_054178123.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    6. XM_054322149.1XP_054178124.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    7. XM_054322147.1XP_054178122.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    8. XM_054322151.1XP_054178126.1  ceramide synthase 4 isoform X1

      UniProtKB/Swiss-Prot
      D6W665, Q9HA82
      UniProtKB/TrEMBL
      Q53HF9
    9. XM_054322152.1XP_054178127.1  ceramide synthase 4 isoform X3

    10. XM_054322153.1XP_054178128.1  ceramide synthase 4 isoform X4