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    MPHOSPH8 M-phase phosphoprotein 8 [ Homo sapiens (human) ]

    Gene ID: 54737, updated on 9-Dec-2024

    Summary

    Official Symbol
    MPHOSPH8provided by HGNC
    Official Full Name
    M-phase phosphoprotein 8provided by HGNC
    Primary source
    HGNC:HGNC:29810
    See related
    Ensembl:ENSG00000196199 MIM:611626; AllianceGenome:HGNC:29810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TWA3; mpp8; HSMPP8
    Summary
    Enables chromatin binding activity; histone reader activity; and methylated histone binding activity. Involved in negative regulation of gene expression via chromosomal CpG island methylation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and positive regulation of DNA methylation-dependent heterochromatin formation. Located in several cellular components, including cytosol; heterochromatin; and nuclear lumen. Part of nucleosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 20.0), spleen (RPKM 15.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MPHOSPH8 in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (19633659..19673441)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (18797911..18869507)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (20207799..20247581)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Neighboring gene uncharacterized LOC124903271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5137 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 2 Neighboring gene TPTE2 antisense RNA 1 Neighboring gene GOLM2 pseudogene 1 Neighboring gene estrogen-related receptor alpha pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:20161162-20161342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7405 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:20173929-20174918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:20219053-20219554 Neighboring gene paraspeckle component 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:20316454-20317223 Neighboring gene RNA, 7SL, cytoplasmic 166, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:20340248-20340748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:20343088-20343647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:20392071-20392598 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35237

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    M-phase phosphoprotein 8
    Names
    M-phase phosphoprotein, mpp
    M-phase phosphoprotein, mpp8
    two hybrid-associated protein 3 with RanBPM
    NP_059990.2
    XP_047286351.1
    XP_047286352.1
    XP_047286353.1
    XP_054230584.1
    XP_054230585.1
    XP_054230586.1
    XP_054230587.1
    XP_054230588.1
    XP_054230589.1
    XP_054230590.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017520.4NP_059990.2  M-phase phosphoprotein 8

      See identical proteins and their annotated locations for NP_059990.2

      Status: VALIDATED

      Source sequence(s)
      AL354808, BC003542, DA672302, R60056
      Consensus CDS
      CCDS9287.1
      UniProtKB/Swiss-Prot
      B7Z6F9, Q5JPE5, Q5JTQ0, Q86TK3, Q96MK4, Q99549, Q9BTP1
      Related
      ENSP00000355388.4, ENST00000361479.10
      Conserved Domains (4) summary
      cd00024
      Location:57109
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00204
      Location:595719
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:606695
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:600631
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      19633659..19673441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430395.1XP_047286351.1  M-phase phosphoprotein 8 isoform X1

    2. XM_047430396.1XP_047286352.1  M-phase phosphoprotein 8 isoform X2

    3. XM_047430397.1XP_047286353.1  M-phase phosphoprotein 8 isoform X3

      UniProtKB/TrEMBL
      B3KS10

    RNA

    1. XR_007063684.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      18797911..18869507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374614.1XP_054230589.1  M-phase phosphoprotein 8 isoform X4

      UniProtKB/Swiss-Prot
      B7Z6F9, Q5JPE5, Q5JTQ0, Q86TK3, Q96MK4, Q99549, Q9BTP1
    2. XM_054374612.1XP_054230587.1  M-phase phosphoprotein 8 isoform X1

    3. XM_054374615.1XP_054230590.1  M-phase phosphoprotein 8 isoform X3

      UniProtKB/TrEMBL
      B3KS10
    4. XM_054374609.1XP_054230584.1  M-phase phosphoprotein 8 isoform X1

    5. XM_054374610.1XP_054230585.1  M-phase phosphoprotein 8 isoform X1

    6. XM_054374611.1XP_054230586.1  M-phase phosphoprotein 8 isoform X1

    7. XM_054374613.1XP_054230588.1  M-phase phosphoprotein 8 isoform X2

    RNA

    1. XR_008488767.1 RNA Sequence