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    GPRIN3 GPRIN family member 3 [ Homo sapiens (human) ]

    Gene ID: 285513, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPRIN3provided by HGNC
    Official Full Name
    GPRIN family member 3provided by HGNC
    Primary source
    HGNC:HGNC:27733
    See related
    Ensembl:ENSG00000185477 MIM:611241; AllianceGenome:HGNC:27733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRIN3
    Summary
    Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in appendix (RPKM 5.7), lymph node (RPKM 5.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPRIN3 in Genome Data Viewer
    Location:
    4q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (89236383..89307800, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (92567541..92638966, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (90157534..90228951, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 907, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr4:90074054-90074582 Neighboring gene uncharacterized LOC124900834 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15569 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:90340115-90340640 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:90340641-90341165 Neighboring gene uncharacterized LOC105377328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:90410728-90411320 Neighboring gene NANOG hESC enhancer GRCh37_chr4:90432809-90433310 Neighboring gene uncharacterized LOC124900855 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:90462817-90463325

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/β-Catenin Signaling Pathway in Gastric Cancer. Zhou W, et al. Pathobiology, 2020. PMID 33254176
    2. Identification and biochemical analysis of GRIN1 and GRIN2. Iida N, et al. Methods Enzymol, 2004. PMID 15488195
    3. Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia. Tarabeux J, et al. Transl Psychiatry, 2011 Nov 15. PMID 22833210, Free PMC Article
    4. PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential. Yadav L, et al. iScience, 2020 Feb 21. PMID 32062451, Free PMC Article
    5. Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho SE, et al. Sci Rep, 2019 Aug 28. PMID 31462741, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/beta-Catenin Signaling Pathway in Gastric Cancer.
      Title: miR-6838-5p Affects Cell Growth, Migration, and Invasion by Targeting GPRIN3 via the Wnt/β-Catenin Signaling Pathway in Gastric Cancer.
    2. Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes.
      Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42625

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G protein-regulated inducer of neurite outgrowth 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198281.3 → NP_938022.2  G protein-regulated inducer of neurite outgrowth 3

      See identical proteins and their annotated locations for NP_938022.2

      Status: VALIDATED

      Source sequence(s)
      AC093862, AC105388
      Consensus CDS
      CCDS34030.1
      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4
      UniProtKB/TrEMBL
      A0AVI5
      Related
      ENSP00000476603.1, ENST00000609438.2
      Conserved Domains (1) summary
      pfam15235
      Location:650 → 771
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      89236383..89307800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008044.2 → XP_016863533.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4
      UniProtKB/TrEMBL
      A0AVI5
      Conserved Domains (1) summary
      pfam15235
      Location:650 → 771
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    2. XM_047450091.1 → XP_047306047.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    3. XM_005262936.4 → XP_005262993.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      See identical proteins and their annotated locations for XP_005262993.1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4
      UniProtKB/TrEMBL
      A0AVI5
      Conserved Domains (1) summary
      pfam15235
      Location:650 → 771
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    4. XM_047450090.1 → XP_047306046.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    5. XM_005262937.5 → XP_005262994.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      See identical proteins and their annotated locations for XP_005262994.1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4
      UniProtKB/TrEMBL
      A0AVI5
      Conserved Domains (1) summary
      pfam15235
      Location:650 → 771
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    6. XM_047450089.1 → XP_047306045.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    7. XM_017008043.2 → XP_016863532.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4
      UniProtKB/TrEMBL
      A0AVI5
      Conserved Domains (1) summary
      pfam15235
      Location:650 → 771
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    8. XM_047450093.1 → XP_047306049.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    9. XM_047450092.1 → XP_047306048.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4
      Related
      ENSP00000328672.3, ENST00000333209.4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      92567541..92638966 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349731.1 → XP_054205706.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    2. XM_054349730.1 → XP_054205705.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    3. XM_054349729.1 → XP_054205704.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    4. XM_054349726.1 → XP_054205701.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    5. XM_054349728.1 → XP_054205703.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    6. XM_054349727.1 → XP_054205702.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    7. XM_054349732.1 → XP_054205707.1  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      UniProtKB/Swiss-Prot
      Q6ZVF9, Q8IVE4

    RNA

    1. XR_007074276.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZVF9.2 GenPept UniProtKB/Swiss-Prot:Q6ZVF9

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