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    MOGAT1 monoacylglycerol O-acyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 116255, updated on 27-Nov-2024

    Summary

    Official Symbol
    MOGAT1provided by HGNC
    Official Full Name
    monoacylglycerol O-acyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:18210
    See related
    Ensembl:ENSG00000124003 MIM:610268; AllianceGenome:HGNC:18210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGAT1; DGAT2L; DGAT2L1
    Summary
    Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in gall bladder (RPKM 7.8) and fat (RPKM 0.6) See more
    Orthologs
    NEW
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    Genomic context

    See MOGAT1 in Genome Data Viewer
    Location:
    2q36.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (222671658..222709930)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (223156723..223195041)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223536377..223574649)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene phenylalanyl-tRNA synthetase subunit beta Neighboring gene uncharacterized LOC105373902 Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17167 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:223521038-223521234 Neighboring gene uncharacterized LOC124907985 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:223553330-223553532 Neighboring gene RRAS2 pseudogene 2 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory regions 6546 and 9925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17169 Neighboring gene Sharpr-MPRA regulatory region 7025 Neighboring gene ribosomal protein L31 pseudogene 17 Neighboring gene uncharacterized LOC105373903

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of monoacylglycerol O-acyltransferase 1 (MOGAT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2-acylglycerol O-acyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in diacylglycerol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    2-acylglycerol O-acyltransferase 1
    Names
    acyl-CoA:monoacylglycerol acyltransferase 1
    diacylglycerol O-acyltransferase 2 like 1
    diacylglycerol O-acyltransferase candidate 2
    diacylglycerol acyltransferase 2-like protein 1
    hDC2
    NP_477513.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_058165.3NP_477513.2  2-acylglycerol O-acyltransferase 1

      See identical proteins and their annotated locations for NP_477513.2

      Status: VALIDATED

      Source sequence(s)
      AC104772, AF384163, BN000154
      Consensus CDS
      CCDS46524.1
      UniProtKB/Swiss-Prot
      Q6IEE5, Q96PD6
      Related
      ENSP00000406674.3, ENST00000446656.4
      Conserved Domains (1) summary
      cl17185
      Location:48335
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      222671658..222709930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      223156723..223195041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)