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    YPEL5 yippee like 5 [ Homo sapiens (human) ]

    Gene ID: 51646, updated on 10-Dec-2024

    Summary

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    Official Symbol
    YPEL5provided by HGNC
    Official Full Name
    yippee like 5provided by HGNC
    Primary source
    HGNC:HGNC:18329
    See related
    Ensembl:ENSG00000119801 MIM:609726; AllianceGenome:HGNC:18329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-127
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 117.0), testis (RPKM 35.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See YPEL5 in Genome Data Viewer
    Location:
    2p23.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (30147007..30160533)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (30191259..30204786)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30369873..30383399)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ALK receptor tyrosine kinase Neighboring gene RNA, 7SL, cytoplasmic 516, pseudogene Neighboring gene uncharacterized LOC124907748 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:30117944-30118493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:30123496-30124120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:30124121-30124745 Neighboring gene NANOG hESC enhancer GRCh37_chr2:30167172-30167673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30186510-30187010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30187011-30187511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30188897-30189398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30189399-30189898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30248848-30249348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11323 Neighboring gene uncharacterized LOC105374414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30413091-30413789 Neighboring gene uncharacterized LOC124907749 Neighboring gene Sharpr-MPRA regulatory region 12598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30416411-30416970 Neighboring gene small nucleolar RNA, H/ACA box 10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. Roxström-Lindquist K, et al. Insect Mol Biol, 2001 Feb. PMID 11240639
    2. Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia. Velusamy T, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382248, Free PMC Article
    3. Pro-Apoptotic Role of the Human YPEL5 Gene Identified by Functional Complementation of a Yeast moh1Δ Mutation. Lee JY, et al. J Microbiol Biotechnol, 2017 Mar 28. PMID 28173693
    4. METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5. Zhou D, et al. Mol Oncol, 2021 Aug. PMID 33411363, Free PMC Article
    5. Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1. Jeidane S, et al. Cell Rep, 2016 Oct 4. PMID 27705791

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.
      Title: METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.
    2. YPEL5 silencing enhanced the induction of IFNB1 by pattern recognition receptors and phosphorylation of TBK1/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE.
      Title: Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.
    3. results demonstrate the functional conservation between yeast Moh1 and human YPEL5, and their involvement in mitochondria-dependent apoptosis induced by DNA damage
      Title: Pro-Apoptotic Role of the Human YPEL5 Gene Identified by Functional Complementation of a Yeast moh1Δ Mutation.
    4. results indicate that SCN-iPS cells provide a useful disease model for SCN, and the activation of the Wnt3a/beta-catenin pathway may offer a novel therapy for SCN with ELANE mutation
      Title: Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia.
    5. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.
      Title: YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein yippee-like 5
    NP_001120871.1
    NP_001120872.1
    NP_001120873.1
    NP_057145.1
    XP_016859807.1
    XP_016859808.1
    XP_016859809.1
    XP_016859810.1
    XP_016859811.1
    XP_047300698.1
    XP_047300699.1
    XP_047300700.1
    XP_054198518.1
    XP_054198519.1
    XP_054198520.1
    XP_054198521.1
    XP_054198522.1
    XP_054198523.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127399.2 → NP_001120871.1  protein yippee-like 5

      See identical proteins and their annotated locations for NP_001120871.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC016907, AK025730
      Consensus CDS
      CCDS1771.1
      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Related
      ENSP00000383974.3, ENST00000402003.7
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. NM_001127400.2 → NP_001120872.1  protein yippee-like 5

      See identical proteins and their annotated locations for NP_001120872.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC016907, AK025730
      Consensus CDS
      CCDS1771.1
      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Related
      ENSP00000368834.3, ENST00000379519.7
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    3. NM_001127401.2 → NP_001120873.1  protein yippee-like 5

      See identical proteins and their annotated locations for NP_001120873.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC016907, AK025730
      Consensus CDS
      CCDS1771.1
      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Related
      ENSP00000368835.3, ENST00000379520.8
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    4. NM_016061.3 → NP_057145.1  protein yippee-like 5

      See identical proteins and their annotated locations for NP_057145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC016907, AF172940, AK025730
      Consensus CDS
      CCDS1771.1
      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Related
      ENSP00000261353.4, ENST00000261353.9
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      30147007..30160533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004322.2 → XP_016859811.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Related
      ENSP00000385278.1, ENST00000402708.5
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. XM_047444743.1 → XP_047300699.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    3. XM_047444744.1 → XP_047300700.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    4. XM_017004318.2 → XP_016859807.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    5. XM_017004320.3 → XP_016859809.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    6. XM_047444742.1 → XP_047300698.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    7. XM_017004319.3 → XP_016859808.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    8. XM_017004321.2 → XP_016859810.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
      Conserved Domains (1) summary
      cl13152
      Location:15 → 107
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      30191259..30204786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342545.1 → XP_054198520.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    2. XM_054342546.1 → XP_054198521.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    3. XM_054342547.1 → XP_054198522.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    4. XM_054342544.1 → XP_054198519.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    5. XM_054342543.1 → XP_054198518.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

    6. XM_054342548.1 → XP_054198523.1  protein yippee-like 5 isoform X1

      UniProtKB/Swiss-Prot
      D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62699.1 GenPept UniProtKB/Swiss-Prot:P62699

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