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    ARHGAP17 Rho GTPase activating protein 17 [ Homo sapiens (human) ]

    Gene ID: 55114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARHGAP17provided by HGNC
    Official Full Name
    Rho GTPase activating protein 17provided by HGNC
    Primary source
    HGNC:HGNC:18239
    See related
    Ensembl:ENSG00000140750 MIM:608293; AllianceGenome:HGNC:18239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP367; RICH1; WBP15; MST066; MST110; NADRIN; PP4534; RICH-1; MSTP038; MSTP066; MSTP110
    Summary
    RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]
    Expression
    Ubiquitous expression in spleen (RPKM 24.3), lymph node (RPKM 19.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGAP17 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (24919389..25015369, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (25199011..25294991, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (24930710..25026690, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10600 Neighboring gene long intergenic non-protein coding RNA 1567 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:24695075-24695665 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24697561-24698060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24834133-24834633 Neighboring gene Sharpr-MPRA regulatory region 7462 Neighboring gene solute carrier family 5 member 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:24917770-24918270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:24999769-25000372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10601 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25025578-25026246 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:25026247-25026915 Neighboring gene thyroid hormone receptor interactor 11 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:25033996-25034167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10602 Neighboring gene leucine carboxyl methyltransferase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling. Pan S, et al. Cell Physiol Biochem, 2018. PMID 29730655
    2. ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42. Wang L, et al. Clin Exp Pharmacol Physiol, 2020 Sep. PMID 32391922
    3. ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia. Kreider-Letterman G, et al. J Cell Biol, 2023 Feb 6. PMID 36571786, Free PMC Article
    4. Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets. Nagy Z, et al. J Biol Chem, 2015 Dec 11. PMID 26507661, Free PMC Article
    5. ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1. Pan SL, et al. Neoplasma, 2022 May. PMID 35293764

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.
      Title: ARHGAP17 regulates the spatiotemporal activity of Cdc42 at invadopodia.
    2. ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1.
      Title: ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer cells by suppressing Rac1.
    3. ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.
      Title: ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.
    4. ARHGAP17 functions as a tumor suppressor in cervical cancer that suppresses tumor growth, at least partly, through inhibition of PI3K/AKT signaling and up-regulation of P21 and P27 expression.
      Title: ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer.
    5. The bevacizumab-independent VEGF/NRP1/ARHGAP17/Cdc42 regulatory network plays important roles in malignant behavior of breast cancer.
      Title: Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network.
    6. In vitro analysis demonstrated that ARHGAP17 overexpression inhibited cell growth and invasion of HCT-8 and HCT-116 cells.
      Title: Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/β-Catenin Signaling.
    7. show that ARHGAP17 binds to the actin-regulating CIP4 protein in platelets and that Ser-702 phosphorylation interferes with this interaction
      Title: Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.
    8. Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway.
      Title: Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. We propose that Rich1 and Amot maintain TJ integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking.
      Title: A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37567, FLJ43368, MGC87805, DKFZp564A1363

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-ion regulated exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 17
    Names
    RhoGAP interacting with CIP4 homologs 1
    neuron-associated developmentally regulated protein
    rho-type GTPase-activating protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006634.3 → NP_001006635.1  rho GTPase-activating protein 17 isoform 1

      See identical proteins and their annotated locations for NP_001006635.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC080195, BU187683
      Consensus CDS
      CCDS32409.1
      UniProtKB/Swiss-Prot
      A8K6M6, Q68EM7, Q6ZUS4, Q7Z2F2, Q8NDG2, Q96KS2, Q96KS3, Q96SS8, Q9BVF6, Q9H8U5, Q9NW54
      UniProtKB/TrEMBL
      A0A2X0SF71
      Related
      ENSP00000289968.6, ENST00000289968.11
      Conserved Domains (4) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      PRK14951
      Location:522 → 631
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in ...
      pfam09770
      Location:536 → 739
      PAT1; Topoisomerase II-associated protein PAT1

    2. NM_018054.6 → NP_060524.4  rho GTPase-activating protein 17 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC080195, BU187683
      Consensus CDS
      CCDS32408.1
      UniProtKB/TrEMBL
      A0A2X0SF71
      Related
      ENSP00000303130.5, ENST00000303665.9
      Conserved Domains (2) summary
      cd07618
      Location:13 → 257
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:246 → 446
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      24919389..25015369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434318.1 → XP_047290274.1  rho GTPase-activating protein 17 isoform X12

      UniProtKB/TrEMBL
      A0A2X0SF71

    2. XM_047434314.1 → XP_047290270.1  rho GTPase-activating protein 17 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SF71

    3. XM_047434313.1 → XP_047290269.1  rho GTPase-activating protein 17 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SF71

    4. XM_011545878.4 → XP_011544180.1  rho GTPase-activating protein 17 isoform X9

      UniProtKB/TrEMBL
      A0A2X0SF71
      Conserved Domains (2) summary
      cd07618
      Location:13 → 289
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:278 → 478
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    5. XM_047434316.1 → XP_047290272.1  rho GTPase-activating protein 17 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SF71

    6. XM_011545873.4 → XP_011544175.1  rho GTPase-activating protein 17 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF71
      Conserved Domains (2) summary
      cd07618
      Location:13 → 289
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:278 → 478
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    7. XM_011545876.3 → XP_011544178.1  rho GTPase-activating protein 17 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SF71
      Conserved Domains (2) summary
      cd07618
      Location:13 → 289
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:278 → 478
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    8. XM_011545875.3 → XP_011544177.1  rho GTPase-activating protein 17 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SF71
      Conserved Domains (2) summary
      cd07618
      Location:13 → 289
      BAR_Rich1; The Bin/Amphiphysin/Rvs (BAR) domain of RhoGAP interacting with CIP4 homologs protein 1
      cd04386
      Location:278 → 478
      RhoGAP_nadrin; RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been ...

    9. XM_047434315.1 → XP_047290271.1  rho GTPase-activating protein 17 isoform X8

      UniProtKB/TrEMBL
      B4DWE9

    10. XM_047434311.1 → XP_047290267.1  rho GTPase-activating protein 17 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF71

    11. XM_047434312.1 → XP_047290268.1  rho GTPase-activating protein 17 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SF71

    12. XM_047434317.1 → XP_047290273.1  rho GTPase-activating protein 17 isoform X11

      UniProtKB/TrEMBL
      A0A2X0SF71

    13. XM_047434319.1 → XP_047290275.1  rho GTPase-activating protein 17 isoform X13

      UniProtKB/TrEMBL
      A0A2X0SF71

    14. XM_047434320.1 → XP_047290276.1  rho GTPase-activating protein 17 isoform X14

    15. XM_047434322.1 → XP_047290278.1  rho GTPase-activating protein 17 isoform X16

    16. XM_047434321.1 → XP_047290277.1  rho GTPase-activating protein 17 isoform X15

    RNA

    1. XR_950809.3 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160019.1 Reference GRCh38.p14 PATCHES

      Range
      172872..268852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332642.1 → XP_054188617.1  rho GTPase-activating protein 17 isoform X12

      UniProtKB/TrEMBL
      A0A2X0SF71

    2. XM_054332637.1 → XP_054188612.1  rho GTPase-activating protein 17 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SF71

    3. XM_054332636.1 → XP_054188611.1  rho GTPase-activating protein 17 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SF71

    4. XM_054332639.1 → XP_054188614.1  rho GTPase-activating protein 17 isoform X9

      UniProtKB/TrEMBL
      A0A2X0SF71

    5. XM_054332640.1 → XP_054188615.1  rho GTPase-activating protein 17 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SF71

    6. XM_054332631.1 → XP_054188606.1  rho GTPase-activating protein 17 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF71

    7. XM_054332635.1 → XP_054188610.1  rho GTPase-activating protein 17 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SF71

    8. XM_054332633.1 → XP_054188608.1  rho GTPase-activating protein 17 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SF71

    9. XM_054332638.1 → XP_054188613.1  rho GTPase-activating protein 17 isoform X8

      UniProtKB/TrEMBL
      B4DWE9

    10. XM_054332632.1 → XP_054188607.1  rho GTPase-activating protein 17 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF71

    11. XM_054332634.1 → XP_054188609.1  rho GTPase-activating protein 17 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SF71

    12. XM_054332641.1 → XP_054188616.1  rho GTPase-activating protein 17 isoform X11

      UniProtKB/TrEMBL
      A0A2X0SF71

    13. XM_054332643.1 → XP_054188618.1  rho GTPase-activating protein 17 isoform X13

      UniProtKB/TrEMBL
      A0A2X0SF71

    14. XM_054332644.1 → XP_054188619.1  rho GTPase-activating protein 17 isoform X14

    15. XM_054332646.1 → XP_054188621.1  rho GTPase-activating protein 17 isoform X16

    16. XM_054332645.1 → XP_054188620.1  rho GTPase-activating protein 17 isoform X15

    RNA

    1. XR_008485785.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      25199011..25294991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380637.1 → XP_054236612.1  rho GTPase-activating protein 17 isoform X12

      UniProtKB/TrEMBL
      A0A2X0SF71

    2. XM_054380632.1 → XP_054236607.1  rho GTPase-activating protein 17 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SF71

    3. XM_054380631.1 → XP_054236606.1  rho GTPase-activating protein 17 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SF71

    4. XM_054380634.1 → XP_054236609.1  rho GTPase-activating protein 17 isoform X9

      UniProtKB/TrEMBL
      A0A2X0SF71

    5. XM_054380635.1 → XP_054236610.1  rho GTPase-activating protein 17 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SF71

    6. XM_054380626.1 → XP_054236601.1  rho GTPase-activating protein 17 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF71

    7. XM_054380630.1 → XP_054236605.1  rho GTPase-activating protein 17 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SF71

    8. XM_054380628.1 → XP_054236603.1  rho GTPase-activating protein 17 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SF71

    9. XM_054380633.1 → XP_054236608.1  rho GTPase-activating protein 17 isoform X8

      UniProtKB/TrEMBL
      B4DWE9

    10. XM_054380627.1 → XP_054236602.1  rho GTPase-activating protein 17 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF71

    11. XM_054380629.1 → XP_054236604.1  rho GTPase-activating protein 17 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SF71

    12. XM_054380636.1 → XP_054236611.1  rho GTPase-activating protein 17 isoform X11

      UniProtKB/TrEMBL
      A0A2X0SF71

    13. XM_054380638.1 → XP_054236613.1  rho GTPase-activating protein 17 isoform X13

      UniProtKB/TrEMBL
      A0A2X0SF71

    14. XM_054380639.1 → XP_054236614.1  rho GTPase-activating protein 17 isoform X14

    15. XM_054380641.1 → XP_054236616.1  rho GTPase-activating protein 17 isoform X16

    16. XM_054380640.1 → XP_054236615.1  rho GTPase-activating protein 17 isoform X15

    RNA

    1. XR_008489101.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68EM7.1 GenPept UniProtKB/Swiss-Prot:Q68EM7

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