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    SLC22A15 solute carrier family 22 member 15 [ Homo sapiens (human) ]

    Gene ID: 55356, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SLC22A15provided by HGNC
    Official Full Name
    solute carrier family 22 member 15provided by HGNC
    Primary source
    HGNC:HGNC:20301
    See related
    Ensembl:ENSG00000163393 MIM:608275; AllianceGenome:HGNC:20301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLIPT1; PRO34686
    Summary
    Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
    Expression
    Broad expression in bone marrow (RPKM 6.8), skin (RPKM 3.1) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC22A15 in Genome Data Viewer
    Location:
    1p13.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (115976513..116070054)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (115984504..116078027)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (116519134..116612675)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A-like Neighboring gene uncharacterized LOC101928977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:116470749-116471250 Neighboring gene long intergenic non-protein coding RNA 1649 Neighboring gene NANOG hESC enhancer GRCh37_chr1:116483799-116484300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1225 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:116531140-116531301 Neighboring gene NANOG hESC enhancer GRCh37_chr1:116590670-116591171 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:116609321-116610520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1556 Neighboring gene uncharacterized LOC105378918 Neighboring gene mab-21 like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1557 Neighboring gene Sharpr-MPRA regulatory region 11424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1227 Neighboring gene uncharacterized LOC124904384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters. Eraly SA, et al. Biochem Biophys Res Commun, 2002 Oct 11. PMID 12372408
    2. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. Yee SW, et al. FASEB J, 2020 Dec. PMID 33124720, Free PMC Article
    3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Yang X, et al. Cell, 2016 Feb 11. PMID 26871637, Free PMC Article
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
      Title: Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Flipts might have a role in carnitine transport, particularly in brain
      Title: Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp761G0313

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amino-acid betaine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino-acid betaine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    solute carrier family 22 member 15
    Names
    flipt 1
    fly-like putative organic ion transporter 1
    fly-like putative transporter 1
    solute carrier family 22 (organic cation transporter), member 15
    trans-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018420.3 → NP_060890.2  solute carrier family 22 member 15

      See identical proteins and their annotated locations for NP_060890.2

      Status: VALIDATED

      Source sequence(s)
      AL353933, AL357137, AL365318, BC026358, BC070033
      Consensus CDS
      CCDS44198.1
      UniProtKB/Swiss-Prot
      A8MUR3, Q6UXP5, Q8IZD6, Q8TAL9, Q9NSH5
      UniProtKB/TrEMBL
      A0A0S2Z6C8
      Related
      ENSP00000358515.4, ENST00000369503.9
      Conserved Domains (1) summary
      cd17377
      Location:71 → 469
      MFS_SLC22A15; Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      115976513..116070054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424416.1 → XP_047280372.1  solute carrier family 22 member 15 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z5M4, B3KWH0

    2. XM_047424412.1 → XP_047280368.1  solute carrier family 22 member 15 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5M4

    3. XM_047424411.1 → XP_047280367.1  solute carrier family 22 member 15 isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    4. XM_047424415.1 → XP_047280371.1  solute carrier family 22 member 15 isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    5. XM_047424414.1 → XP_047280370.1  solute carrier family 22 member 15 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    6. XM_024448239.2 → XP_024304007.1  solute carrier family 22 member 15 isoform X8

      UniProtKB/TrEMBL
      A0A0S2Z5P9
      Conserved Domains (1) summary
      cl26863
      Location:94 → 394
      Sugar_tr; Sugar (and other) transporter

    7. XM_024448238.2 → XP_024304006.1  solute carrier family 22 member 15 isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z5P9
      Conserved Domains (1) summary
      cl26863
      Location:94 → 394
      Sugar_tr; Sugar (and other) transporter

    8. XM_005271004.4 → XP_005271061.1  solute carrier family 22 member 15 isoform X10

      Conserved Domains (1) summary
      cd06174
      Location:111 → 246
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    9. XM_047424419.1 → XP_047280375.1  solute carrier family 22 member 15 isoform X12

    10. XM_047424420.1 → XP_047280376.1  solute carrier family 22 member 15 isoform X13

    11. XM_047424422.1 → XP_047280378.1  solute carrier family 22 member 15 isoform X15

      Related
      ENSP00000358514.1, ENST00000369502.1

    12. XM_047424417.1 → XP_047280373.1  solute carrier family 22 member 15 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z5M4, B3KWH0

    13. XM_047424413.1 → XP_047280369.1  solute carrier family 22 member 15 isoform X4

      UniProtKB/TrEMBL
      A0A0S2Z5M4

    14. XM_047424410.1 → XP_047280366.1  solute carrier family 22 member 15 isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z5M4

    15. XM_047424418.1 → XP_047280374.1  solute carrier family 22 member 15 isoform X11

    16. XM_047424421.1 → XP_047280377.1  solute carrier family 22 member 15 isoform X14

    RNA

    1. XR_002957027.2 RNA Sequence

    2. XR_002957032.2 RNA Sequence

    3. XR_007061934.1 RNA Sequence

    4. XR_007061933.1 RNA Sequence

    5. XR_007061932.1 RNA Sequence

    6. XR_007061935.1 RNA Sequence

    7. XR_007061937.1 RNA Sequence

    8. XR_007061936.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      115984504..116078027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337513.1 → XP_054193488.1  solute carrier family 22 member 15 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z5M4, B3KWH0

    2. XM_054337507.1 → XP_054193482.1  solute carrier family 22 member 15 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5M4

    3. XM_054337506.1 → XP_054193481.1  solute carrier family 22 member 15 isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    4. XM_054337511.1 → XP_054193486.1  solute carrier family 22 member 15 isoform X7

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    5. XM_054337509.1 → XP_054193484.1  solute carrier family 22 member 15 isoform X5

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    6. XM_054337512.1 → XP_054193487.1  solute carrier family 22 member 15 isoform X8

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    7. XM_054337510.1 → XP_054193485.1  solute carrier family 22 member 15 isoform X6

      UniProtKB/TrEMBL
      A0A0S2Z5P9

    8. XM_054337515.1 → XP_054193490.1  solute carrier family 22 member 15 isoform X10

    9. XM_054337517.1 → XP_054193492.1  solute carrier family 22 member 15 isoform X12

    10. XM_054337518.1 → XP_054193493.1  solute carrier family 22 member 15 isoform X13

    11. XM_054337520.1 → XP_054193495.1  solute carrier family 22 member 15 isoform X15

    12. XM_054337514.1 → XP_054193489.1  solute carrier family 22 member 15 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z5M4, B3KWH0

    13. XM_054337508.1 → XP_054193483.1  solute carrier family 22 member 15 isoform X4

      UniProtKB/TrEMBL
      A0A0S2Z5M4

    14. XM_054337505.1 → XP_054193480.1  solute carrier family 22 member 15 isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z5M4

    15. XM_054337516.1 → XP_054193491.1  solute carrier family 22 member 15 isoform X11

    16. XM_054337519.1 → XP_054193494.1  solute carrier family 22 member 15 isoform X14

    RNA

    1. XR_008486095.1 RNA Sequence

    2. XR_008486098.1 RNA Sequence

    3. XR_008486097.1 RNA Sequence

    4. XR_008486096.1 RNA Sequence

    5. XR_008486094.1 RNA Sequence

    6. XR_008486099.1 RNA Sequence

    7. XR_008486101.1 RNA Sequence

    8. XR_008486100.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZD6.1 GenPept UniProtKB/Swiss-Prot:Q8IZD6

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