U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from OMIM

    • Showing Current items.

    EXOSC6 exosome component 6 [ Homo sapiens (human) ]

    Gene ID: 118460, updated on 27-Nov-2024

    Summary

    Official Symbol
    EXOSC6provided by HGNC
    Official Full Name
    exosome component 6provided by HGNC
    Primary source
    HGNC:HGNC:19055
    See related
    Ensembl:ENSG00000223496 MIM:606490; AllianceGenome:HGNC:19055
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p11; EAP4; MTR3; Mtr3p; hMtr3p
    Summary
    This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EXOSC6 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70246778..70251940, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76057779..76062933, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70280681..70285843, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371328 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70238115-70238280 Neighboring gene SMG1 pseudogene 7 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:70286884-70287384 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70294233-70294475 Neighboring gene alanyl-tRNA synthetase 1 Neighboring gene RNA, 7SL, cytoplasmic 279, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:70317824-70318022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7671 Neighboring gene Sharpr-MPRA regulatory region 7868 Neighboring gene DEAD-box helicase 19B Neighboring gene DDX19A divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:70366483-70367682

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA deamination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in isotype switching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of isotype switching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytoplasmic exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of nucleolar exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    exosome complex component MTR3
    Names
    Mtr3 (mRNA transport regulator 3)-homolog
    exosome complex exonuclease MTR3
    homolog of yeast mRNA transport regulator 3
    mRNA transport regulator 3 homolog
    NP_478126.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_058219.3NP_478126.1  exosome complex component MTR3

      See identical proteins and their annotated locations for NP_478126.1

      Status: REVIEWED

      Source sequence(s)
      AC009060, BC052252, CX866575
      Consensus CDS
      CCDS10887.1
      UniProtKB/Swiss-Prot
      Q5RKV6
      Related
      ENSP00000398597.1, ENST00000435634.3
      Conserved Domains (1) summary
      cd11371
      Location:36260
      RNase_PH_MTR3; MTR3 subunit of eukaryotic exosome

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      70246778..70251940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      76057779..76062933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)