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    CABIN1 calcineurin binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 23523, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CABIN1provided by HGNC
    Official Full Name
    calcineurin binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24187
    See related
    Ensembl:ENSG00000099991 MIM:604251; AllianceGenome:HGNC:24187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAIN; PPP3IN; KB-318B8.7
    Summary
    Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.8), testis (RPKM 6.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CABIN1 in Genome Data Viewer
    Location:
    22q11.23
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (24011304..24178628)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24472930..24640242)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24407754..24574596)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372959 Neighboring gene glutathione S-transferase theta 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24487229-24487730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24487731-24488230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24527017-24527518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24540118-24540852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24540853-24541588 Neighboring gene Sharpr-MPRA regulatory region 1007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18761 Neighboring gene skeletal muscle cis-regulatory module in CABIN1 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24571075-24571934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24585541-24586182 Neighboring gene MPRA-validated peak4472 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18765 Neighboring gene sushi domain containing 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24601258-24602226 Neighboring gene uncharacterized LOC124905090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24609597-24610123

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Endogenous protein inhibitors of calcineurin. Liu JO. Biochem Biophys Res Commun, 2003 Nov 28. PMID 14623296
    2. Selection of choriocarcinoma-associated genes using bioinformatics. Li XN, et al. Di Yi Jun Yi Da Xue Xue Bao, 2005 Jan. PMID 15683985
    3. A case-control association analysis of CABIN1 with schizophrenia in a Japanese population. Watanabe Y, et al. J Hum Genet, 2010 Mar. PMID 20075944
    4. A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function. Ricketts MD, et al. J Mol Biol, 2017 Jun 30. PMID 27871933, Free PMC Article
    5. EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression. Chang PY, et al. J Cell Physiol, 2014 Mar. PMID 23939952

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the trimeric HIRA, UBN1 and CABIN1 H3.3 histone chaperone complex
      Title: Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.
    2. Results indicate an important role for LMP1 and Cabin1 in regulating apoptosis in nasopharyngeal carcinoma cells in response to genotoxic stress.
      Title: EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression.
    3. Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1.
      Title: Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.
    4. Our findings demonstrate that hCABIN-1 plays a critical role in promoting apoptosis of fibroblast-like synoviocytes and in attenuating inflammation and cartilage and bone destruction in rheumatoid arthritis.
      Title: Regulation of inflammatory responses and fibroblast-like synoviocyte apoptosis by calcineurin-binding protein 1 in mice with collagen-induced arthritis.
    5. NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex
      Title: Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex.
    6. Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells.
      Title: Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.
    7. CABIN1 may not confer increased susceptibility for schizophrenia in the Japanese population.
      Title: A case-control association analysis of CABIN1 with schizophrenia in a Japanese population.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. the association of CAIN with intracellular domains involved in mGluR/G protein coupling provides a mechanism by which Group I mGluR endocytosis and signaling are regulated
      Title: Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.
    EBI GWAS Catalog
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0330

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcineurin-binding protein cabin-1
    Names
    calcineurin binding protein cabin 1
    calcineurin inhibitor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047136.1 RefSeqGene

      Range
      5113..172437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001199281.1 → NP_001186210.1  calcineurin-binding protein cabin-1 isoform a

      See identical proteins and their annotated locations for NP_001186210.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AB002328, AL703593
      Consensus CDS
      CCDS13823.1
      UniProtKB/Swiss-Prot
      G5E9F3, Q6PHY0, Q9Y460, Q9Y6J0
      Related
      ENSP00000381364.2, ENST00000398319.6
      Conserved Domains (6) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2156 → 2190
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      pfam15444
      Location:1945 → 2030
      TMEM247; Transmembrane protein 247
      pfam16181
      Location:2002 → 2130
      RelB_transactiv; RelB transactivation domain

    2. NM_001201429.2 → NP_001188358.1  calcineurin-binding protein cabin-1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AB002328, AC253536, AF072441, BC054497
      Consensus CDS
      CCDS74830.1
      UniProtKB/TrEMBL
      A0A087WWW8
      Related
      ENSP00000480560.1, ENST00000617531.4
      Conserved Domains (4) summary
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13839
      Location:2106 → 2140
      MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      cl26464
      Location:1864 → 2107
      Atrophin-1; Atrophin-1 family

    3. NM_012295.4 → NP_036427.1  calcineurin-binding protein cabin-1 isoform a

      See identical proteins and their annotated locations for NP_036427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC253536, AF072441
      Consensus CDS
      CCDS13823.1
      UniProtKB/Swiss-Prot
      G5E9F3, Q6PHY0, Q9Y460, Q9Y6J0
      Related
      ENSP00000263119.5, ENST00000263119.10
      Conserved Domains (6) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2156 → 2190
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      pfam15444
      Location:1945 → 2030
      TMEM247; Transmembrane protein 247
      pfam16181
      Location:2002 → 2130
      RelB_transactiv; RelB transactivation domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      24011304..24178628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441218.1 → XP_047297174.1  calcineurin-binding protein cabin-1 isoform X4

    2. XM_047441219.1 → XP_047297175.1  calcineurin-binding protein cabin-1 isoform X6

      UniProtKB/Swiss-Prot
      G5E9F3, Q6PHY0, Q9Y460, Q9Y6J0

    3. XM_047441226.1 → XP_047297182.1  calcineurin-binding protein cabin-1 isoform X12

    4. XM_047441232.1 → XP_047297188.1  calcineurin-binding protein cabin-1 isoform X15

    5. XM_024452184.2 → XP_024307952.1  calcineurin-binding protein cabin-1 isoform X1

      Conserved Domains (4) summary
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13839
      Location:2191 → 2225
      MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      cl26464
      Location:1949 → 2192
      Atrophin-1; Atrophin-1 family

    6. XM_047441217.1 → XP_047297173.1  calcineurin-binding protein cabin-1 isoform X4

    7. XM_047441221.1 → XP_047297177.1  calcineurin-binding protein cabin-1 isoform X9

    8. XM_047441224.1 → XP_047297180.1  calcineurin-binding protein cabin-1 isoform X12

    9. XM_047441222.1 → XP_047297178.1  calcineurin-binding protein cabin-1 isoform X10

    10. XM_047441225.1 → XP_047297181.1  calcineurin-binding protein cabin-1 isoform X11

    11. XM_047441236.1 → XP_047297192.1  calcineurin-binding protein cabin-1 isoform X19

    12. XM_047441227.1 → XP_047297183.1  calcineurin-binding protein cabin-1 isoform X13

    13. XM_047441238.1 → XP_047297194.1  calcineurin-binding protein cabin-1 isoform X20

    14. XM_047441240.1 → XP_047297196.1  calcineurin-binding protein cabin-1 isoform X21

    15. XM_047441220.1 → XP_047297176.1  calcineurin-binding protein cabin-1 isoform X8

    16. XM_047441234.1 → XP_047297190.1  calcineurin-binding protein cabin-1 isoform X16

    17. XM_005261419.3 → XP_005261476.1  calcineurin-binding protein cabin-1 isoform X7

      Conserved Domains (4) summary
      COG0457
      Location:14 → 165
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13839
      Location:2146 → 2180
      MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
      sd00006
      Location:36 → 64
      TPR; TPR repeat [structural motif]
      cl26464
      Location:1904 → 2147
      Atrophin-1; Atrophin-1 family

    18. XM_047441229.1 → XP_047297185.1  calcineurin-binding protein cabin-1 isoform X14

    19. XM_047441231.1 → XP_047297187.1  calcineurin-binding protein cabin-1 isoform X15

    20. XM_047441244.1 → XP_047297200.1  calcineurin-binding protein cabin-1 isoform X23

    21. XM_047441243.1 → XP_047297199.1  calcineurin-binding protein cabin-1 isoform X22

    22. XM_047441246.1 → XP_047297202.1  calcineurin-binding protein cabin-1 isoform X26

    23. XM_047441249.1 → XP_047297205.1  calcineurin-binding protein cabin-1 isoform X29

    24. XM_005261415.4 → XP_005261472.1  calcineurin-binding protein cabin-1 isoform X1

      Conserved Domains (4) summary
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13839
      Location:2191 → 2225
      MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      cl26464
      Location:1949 → 2192
      Atrophin-1; Atrophin-1 family

    25. XM_006724179.3 → XP_006724242.1  calcineurin-binding protein cabin-1 isoform X3

      Conserved Domains (4) summary
      PHA03247
      Location:1948 → 2200
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2162 → 2196
      MEF2_binding; MEF2 binding

    26. XM_005261416.4 → XP_005261473.1  calcineurin-binding protein cabin-1 isoform X2

      Conserved Domains (6) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2186 → 2220
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      pfam15444
      Location:1975 → 2060
      TMEM247; Transmembrane protein 247
      pfam16181
      Location:2032 → 2160
      RelB_transactiv; RelB transactivation domain

    27. XM_017028680.3 → XP_016884169.1  calcineurin-binding protein cabin-1 isoform X5

    28. XM_005261417.4 → XP_005261474.1  calcineurin-binding protein cabin-1 isoform X4

      Conserved Domains (6) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2161 → 2195
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      pfam15444
      Location:1950 → 2035
      TMEM247; Transmembrane protein 247
      pfam16181
      Location:2007 → 2135
      RelB_transactiv; RelB transactivation domain

    29. XM_006724181.3 → XP_006724244.1  calcineurin-binding protein cabin-1 isoform X12

      Conserved Domains (5) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2127 → 2161
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      cl21589
      Location:1909 → 2098
      Relaxase; Relaxase/Mobilization nuclease domain

    30. XM_006724180.3 → XP_006724243.1  calcineurin-binding protein cabin-1 isoform X10

      Conserved Domains (6) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2132 → 2166
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      pfam15444
      Location:1921 → 2006
      TMEM247; Transmembrane protein 247
      pfam16181
      Location:1978 → 2106
      RelB_transactiv; RelB transactivation domain

    31. XM_047441223.1 → XP_047297179.1  calcineurin-binding protein cabin-1 isoform X11

    32. XM_011530026.3 → XP_011528328.1  calcineurin-binding protein cabin-1 isoform X13

      Conserved Domains (6) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2126 → 2160
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      pfam15444
      Location:1915 → 2000
      TMEM247; Transmembrane protein 247
      pfam16181
      Location:1972 → 2100
      RelB_transactiv; RelB transactivation domain

    33. XM_047441237.1 → XP_047297193.1  calcineurin-binding protein cabin-1 isoform X20

    34. XM_047441239.1 → XP_047297195.1  calcineurin-binding protein cabin-1 isoform X21

    35. XM_017028681.3 → XP_016884170.1  calcineurin-binding protein cabin-1 isoform X8

    36. XM_047441235.1 → XP_047297191.1  calcineurin-binding protein cabin-1 isoform X17

    37. XM_047441233.1 → XP_047297189.1  calcineurin-binding protein cabin-1 isoform X16

    38. XM_024452187.2 → XP_024307955.1  calcineurin-binding protein cabin-1 isoform X18

      UniProtKB/TrEMBL
      A0A087WWW8
      Conserved Domains (4) summary
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13839
      Location:2106 → 2140
      MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      cl26464
      Location:1864 → 2107
      Atrophin-1; Atrophin-1 family

    39. XM_047441245.1 → XP_047297201.1  calcineurin-binding protein cabin-1 isoform X25

    40. XM_017028683.3 → XP_016884172.1  calcineurin-binding protein cabin-1 isoform X24

      UniProtKB/Swiss-Prot
      Q9Y6J0
      Related
      ENSP00000384694.2, ENST00000405822.6
      Conserved Domains (6) summary
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2077 → 2111
      MEF2_binding; MEF2 binding
      pfam13414
      Location:92 → 155
      TPR_11; TPR repeat
      pfam13424
      Location:36 → 120
      TPR_12; Tetratricopeptide repeat
      pfam15444
      Location:1866 → 1951
      TMEM247; Transmembrane protein 247
      pfam16181
      Location:1923 → 2051
      RelB_transactiv; RelB transactivation domain

    41. XM_024452186.2 → XP_024307954.1  calcineurin-binding protein cabin-1 isoform X7

      Conserved Domains (4) summary
      COG0457
      Location:14 → 165
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd13839
      Location:2146 → 2180
      MEF2_binding; Mycocyte enhancer factor-2 (MEF2) binding domain of the calcineurin-binding protein cabin-1
      sd00006
      Location:36 → 64
      TPR; TPR repeat [structural motif]
      cl26464
      Location:1904 → 2147
      Atrophin-1; Atrophin-1 family

    42. XM_047441228.1 → XP_047297184.1  calcineurin-binding protein cabin-1 isoform X14

    43. XM_047441230.1 → XP_047297186.1  calcineurin-binding protein cabin-1 isoform X15

    44. XM_047441242.1 → XP_047297198.1  calcineurin-binding protein cabin-1 isoform X23

    45. XM_047441241.1 → XP_047297197.1  calcineurin-binding protein cabin-1 isoform X22

    46. XM_047441247.1 → XP_047297203.1  calcineurin-binding protein cabin-1 isoform X27

    47. XM_047441248.1 → XP_047297204.1  calcineurin-binding protein cabin-1 isoform X28

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187633.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      301995..302395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      24472930..24640242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325320.1 → XP_054181295.1  calcineurin-binding protein cabin-1 isoform X4

    2. XM_054325322.1 → XP_054181297.1  calcineurin-binding protein cabin-1 isoform X6

      UniProtKB/Swiss-Prot
      G5E9F3, Q6PHY0, Q9Y460, Q9Y6J0

    3. XM_054325333.1 → XP_054181308.1  calcineurin-binding protein cabin-1 isoform X12

    4. XM_054325340.1 → XP_054181315.1  calcineurin-binding protein cabin-1 isoform X15

    5. XM_054325314.1 → XP_054181289.1  calcineurin-binding protein cabin-1 isoform X1

    6. XM_054325317.1 → XP_054181292.1  calcineurin-binding protein cabin-1 isoform X3

    7. XM_054325318.1 → XP_054181293.1  calcineurin-binding protein cabin-1 isoform X4

    8. XM_054325327.1 → XP_054181302.1  calcineurin-binding protein cabin-1 isoform X9

    9. XM_054325330.1 → XP_054181305.1  calcineurin-binding protein cabin-1 isoform X12

    10. XM_054325328.1 → XP_054181303.1  calcineurin-binding protein cabin-1 isoform X10

    11. XM_054325331.1 → XP_054181306.1  calcineurin-binding protein cabin-1 isoform X11

    12. XM_054325346.1 → XP_054181321.1  calcineurin-binding protein cabin-1 isoform X19

    13. XM_054325335.1 → XP_054181310.1  calcineurin-binding protein cabin-1 isoform X13

    14. XM_054325347.1 → XP_054181322.1  calcineurin-binding protein cabin-1 isoform X20

    15. XM_054325349.1 → XP_054181324.1  calcineurin-binding protein cabin-1 isoform X21

    16. XM_054325325.1 → XP_054181300.1  calcineurin-binding protein cabin-1 isoform X8

    17. XM_054325343.1 → XP_054181318.1  calcineurin-binding protein cabin-1 isoform X16

    18. XM_054325323.1 → XP_054181298.1  calcineurin-binding protein cabin-1 isoform X7

    19. XM_054325338.1 → XP_054181313.1  calcineurin-binding protein cabin-1 isoform X14

    20. XM_054325339.1 → XP_054181314.1  calcineurin-binding protein cabin-1 isoform X15

    21. XM_054325353.1 → XP_054181328.1  calcineurin-binding protein cabin-1 isoform X23

    22. XM_054325351.1 → XP_054181326.1  calcineurin-binding protein cabin-1 isoform X22

    23. XM_054325356.1 → XP_054181331.1  calcineurin-binding protein cabin-1 isoform X26

    24. XM_054325358.1 → XP_054181333.1  calcineurin-binding protein cabin-1 isoform X30

    25. XM_054325359.1 → XP_054181334.1  calcineurin-binding protein cabin-1 isoform X28

    26. XM_054325360.1 → XP_054181335.1  calcineurin-binding protein cabin-1 isoform X29

    27. XM_054325315.1 → XP_054181290.1  calcineurin-binding protein cabin-1 isoform X1

    28. XM_054325316.1 → XP_054181291.1  calcineurin-binding protein cabin-1 isoform X2

    29. XM_054325321.1 → XP_054181296.1  calcineurin-binding protein cabin-1 isoform X5

    30. XM_054325319.1 → XP_054181294.1  calcineurin-binding protein cabin-1 isoform X4

    31. XM_054325332.1 → XP_054181307.1  calcineurin-binding protein cabin-1 isoform X12

    32. XM_054325329.1 → XP_054181304.1  calcineurin-binding protein cabin-1 isoform X10

    33. XM_054325334.1 → XP_054181309.1  calcineurin-binding protein cabin-1 isoform X11

    34. XM_054325336.1 → XP_054181311.1  calcineurin-binding protein cabin-1 isoform X13

    35. XM_054325348.1 → XP_054181323.1  calcineurin-binding protein cabin-1 isoform X21

    36. XM_054325326.1 → XP_054181301.1  calcineurin-binding protein cabin-1 isoform X8

    37. XM_054325344.1 → XP_054181319.1  calcineurin-binding protein cabin-1 isoform X17

    38. XM_054325342.1 → XP_054181317.1  calcineurin-binding protein cabin-1 isoform X16

    39. XM_054325345.1 → XP_054181320.1  calcineurin-binding protein cabin-1 isoform X18

      UniProtKB/TrEMBL
      A0A087WWW8

    40. XM_054325355.1 → XP_054181330.1  calcineurin-binding protein cabin-1 isoform X25

    41. XM_054325354.1 → XP_054181329.1  calcineurin-binding protein cabin-1 isoform X24

    42. XM_054325324.1 → XP_054181299.1  calcineurin-binding protein cabin-1 isoform X7

    43. XM_054325337.1 → XP_054181312.1  calcineurin-binding protein cabin-1 isoform X14

    44. XM_054325341.1 → XP_054181316.1  calcineurin-binding protein cabin-1 isoform X15

    45. XM_054325352.1 → XP_054181327.1  calcineurin-binding protein cabin-1 isoform X23

    46. XM_054325350.1 → XP_054181325.1  calcineurin-binding protein cabin-1 isoform X22

    47. XM_054325357.1 → XP_054181332.1  calcineurin-binding protein cabin-1 isoform X27

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6J0.1 GenPept UniProtKB/Swiss-Prot:Q9Y6J0

    Gene LinkOut

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