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    TAF6L TATA-box binding protein associated factor 6 like [ Homo sapiens (human) ]

    Gene ID: 10629, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TAF6Lprovided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 6 likeprovided by HGNC
    Primary source
    HGNC:HGNC:17305
    See related
    Ensembl:ENSG00000162227 MIM:602946; AllianceGenome:HGNC:17305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAF65A
    Summary
    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 7.9), fat (RPKM 5.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAF6L in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62771396..62787342)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62760716..62776733)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62538868..62554814)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62520285-62521162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62522043-62522920 Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62524299-62524825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4844 Neighboring gene RNA polymerase II subunit G Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4846 Neighboring gene transmembrane protein 223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3430 Neighboring gene transmembrane protein 179B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3431 Neighboring gene microRNA 6748 Neighboring gene microRNA 6514 Neighboring gene nuclear RNA export factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Pitkänen J, et al. Biochem Biophys Res Commun, 2005 Aug 5. PMID 15964547
    2. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Zeng L, et al. Structure, 2008 Apr. PMID 18400184, Free PMC Article
    3. PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation. Clarke DL, et al. J Immunol, 2008 Sep 1. PMID 18714023
    4. Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis. Arimoto KI, et al. Nat Commun, 2023 Jan 17. PMID 36646704, Free PMC Article
    5. The TAFs in the HAT. Struhl K, et al. Cell, 1998 Jul 10. PMID 9674419

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4288, FLJ11136

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of somatic stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    part_of histone deacetylase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
    Names
    PAF65-alpha
    PCAF-associated factor 65-alpha
    TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
    p300/CBP-associated factor (PCAF)-associated factor 65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006473.4 → NP_006464.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

      See identical proteins and their annotated locations for NP_006464.1

      Status: REVIEWED

      Source sequence(s)
      AK289499, BC008785, DC311213
      Consensus CDS
      CCDS8035.1
      UniProtKB/Swiss-Prot
      B2RAT0, Q96HA6, Q9Y6J9
      UniProtKB/TrEMBL
      A8K0D4
      Related
      ENSP00000294168.3, ENST00000294168.8
      Conserved Domains (2) summary
      pfam02969
      Location:9 → 73
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:153 → 365
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62771396..62787342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273714.3 → XP_005273771.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      UniProtKB/TrEMBL
      A8K0D4
      Conserved Domains (2) summary
      pfam02969
      Location:9 → 73
      TAF; TATA box binding protein associated factor (TAF)
      cd08050
      Location:145 → 356
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    2. XM_017017100.3 → XP_016872589.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62760716..62776733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367483.1 → XP_054223458.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    2. XM_054367484.1 → XP_054223459.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6J9.1 GenPept UniProtKB/Swiss-Prot:Q9Y6J9

    Gene LinkOut

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