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    PEG3 paternally expressed 3 [ Homo sapiens (human) ]

    Gene ID: 5178, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PEG3provided by HGNC
    Official Full Name
    paternally expressed 3provided by HGNC
    Primary source
    HGNC:HGNC:8826
    See related
    Ensembl:ENSG00000198300 MIM:601483; AllianceGenome:HGNC:8826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PW1; ZNF904; ZSCAN24; ZKSCAN22
    Summary
    In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
    Expression
    Biased expression in ovary (RPKM 126.4), placenta (RPKM 67.7) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PEG3 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56810082..56840726, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59905167..59935794, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57321450..57352094, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily AH member 1 pseudogene Neighboring gene ZIM2 antisense RNA 1 Neighboring gene zinc finger imprinted 2 Neighboring gene PEG3 antisense RNA 1 Neighboring gene MER1 repeat containing imprinted transcript 1 Neighboring gene uncharacterized LOC124904779

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence. Bonfanti C, et al. Nat Commun, 2015 Mar 9. PMID 25751651, Free PMC Article
    2. Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma. Otsuka S, et al. Proc Jpn Acad Ser B Phys Biol Sci, 2009. PMID 19367087, Free PMC Article
    3. Resident PW1+ Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension. Dierick F, et al. Circ Res, 2016 Mar 4. PMID 26838788
    4. PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer. Zhang M, et al. Biosci Rep, 2020 Aug 28. PMID 32729618, Free PMC Article
    5. The imprinted gene PEG3 inhibits Wnt signaling and regulates glioma growth. Jiang X, et al. J Biol Chem, 2010 Mar 12. PMID 20064927, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
      Title: Epigenetic reactivation of PEG3 by EZH2 inhibitors suppresses renal clear cell carcinoma progress.
    2. miR-155-5p Promotes Cell Proliferation and Migration of Clear Cell Renal Cell Carcinoma by Targeting PEG3.
      Title: miR-155-5p Promotes Cell Proliferation and Migration of Clear Cell Renal Cell Carcinoma by Targeting PEG3.
    3. HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
      Title: HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer.
    4. PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer.
      Title: PEG3 mutation is associated with elevated tumor mutation burden and poor prognosis in breast cancer.
    5. These key findings demonstrated that upregulation of ZNF667-AS1 could suppress the progression of cervical cancer via the modulation of miR-93-3p-dependent PEG3.
      Title: Long noncoding RNA ZNF667-AS1 reduces tumor invasion and metastasis in cervical cancer by counteracting microRNA-93-3p-dependent PEG3 downregulation.
    6. Soluble matrix-derived cues being transduced downstream of receptor engagement converge upon a newly-discovered nexus of autophagic machinery consisting of Peg3 for endothelial cell autophagy and mitostatin for tumor cell mitophagy.
      Title: Decorin is a devouring proteoglycan: Remodeling of intracellular catabolism via autophagy and mitophagy.
    7. Peg3 expression levels anti-correlate with pluripotency and increase gradually upon ESC differentiation. Moreover, downregulation of Peg3 enhances the efficiency of reprogramming of differentiated cells towards pluripotency.
      Title: Reduced expression of Paternally Expressed Gene-3 enhances somatic cell reprogramming through mitochondrial activity perturbation.
    8. Data suggest that PEG3 is required for TFEB induction and nuclear translocation in a VEGFR2- and AMPK-dependent manner for decorin/decorin receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB = transcription factor EB; VEGFR2 = vascular endothelial growth factor receptor-2; AMPK = AMP-activated protein kinase)
      Title: Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy.
    9. Peg3 transcriptionally modulates BECN1 activity.
      Title: Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis.
    10. Data indicate that a set of cis-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain.
      Title: Phylogenetic and Epigenetic Footprinting of the Putative Enhancers of the Peg3 Domain.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-05-17)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-05-17)

    ClinGen Genome Curation Page

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0287, DKFZp781A095

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    paternally-expressed gene 3 protein
    Names
    Kruppel-type zinc finger protein
    zinc finger and SCAN domain-containing protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012989.1 RefSeqGene

      Range
      5004..35648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001146184.2 → NP_001139656.1  paternally-expressed gene 3 protein isoform 1

      See identical proteins and their annotated locations for NP_001139656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing a 5' non-coding exon, therefore, has a shorter 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AF208967, AF208968, AI089069, AK295679, BC037330, CR933682
      Consensus CDS
      CCDS12948.1
      UniProtKB/Swiss-Prot
      A7E2B8, B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZU2, Q9GZY2
      UniProtKB/TrEMBL
      Q96Q96
      Related
      ENSP00000469486.1, ENST00000599577.5
      Conserved Domains (5) summary
      PHA00666
      Location:1421 → 1501
      PHA00666; putative protease
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:969 → 991
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 124
      SCAN; SCAN domain
      pfam08648
      Location:141 → 237
      DUF1777; Protein of unknown function (DUF1777)

    2. NM_001146185.2 → NP_001139657.1  paternally-expressed gene 3 protein isoform 2

      See identical proteins and their annotated locations for NP_001139657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is missing a 5' non-coding exon, and uses an alternate acceptor splice site at the first coding exon compared to variant 1. This results in the use of an in-frame downstream start codon, and an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AF208967, AF208969, AI089069, AK295679, BC037330, CR933682
      Consensus CDS
      CCDS58685.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000472402.1, ENST00000593695.5
      Conserved Domains (4) summary
      PHA00666
      Location:1295 → 1375
      PHA00666; putative protease
      sd00017
      Location:381 → 401
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:843 → 865
      zf-C2H2; Zinc finger, C2H2 type
      pfam08648
      Location:15 → 111
      DUF1777; Protein of unknown function (DUF1777)

    3. NM_001146187.2 → NP_001139659.1  paternally-expressed gene 3 protein isoform 3

      See identical proteins and their annotated locations for NP_001139659.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) is missing a 5' non-coding exon, and uses alternate splice sites at several coding exons compared to variant 1. This results in the use of an in-frame downstream start codon, and an isoform (3) with a shorter N-terminus and two additional internal aa compared to isoform 1. Variants 5, 9-22, and 30 all encode the same isoform (3).
      Source sequence(s)
      AB006625, AF208967, AI089069, AK295679, BC037330, CR933682
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000473190.1, ENST00000598410.5
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_001369717.1 → NP_001356646.1  paternally-expressed gene 3 protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes the longest isoform (4).
      Source sequence(s)
      AC006115
      UniProtKB/TrEMBL
      Q96Q96
      Conserved Domains (4) summary
      PHA03169
      Location:1421 → 1505
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:971 → 993
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 129
      SCAN; SCAN domain

    5. NM_001369718.1 → NP_001356647.1  paternally-expressed gene 3 protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes the longest isoform (4).
      Source sequence(s)
      AC006115
      UniProtKB/TrEMBL
      Q96Q96
      Conserved Domains (4) summary
      PHA03169
      Location:1421 → 1505
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:971 → 993
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 129
      SCAN; SCAN domain

    6. NM_001369719.1 → NP_001356648.1  paternally-expressed gene 3 protein isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC006115
      UniProtKB/TrEMBL
      Q96Q96
      Conserved Domains (4) summary
      PHA03169
      Location:1390 → 1474
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:478 → 498
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:940 → 962
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 129
      SCAN; SCAN domain

    7. NM_001369720.1 → NP_001356649.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 5, 10-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000497332.1, ENST00000647852.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    8. NM_001369721.1 → NP_001356650.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 5, 9, 11-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    9. NM_001369722.1 → NP_001356651.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 5, 9, 10, 12-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000497512.1, ENST00000649680.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    10. NM_001369723.1 → NP_001356652.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 5, 9-11, 13-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000497466.1, ENST00000650102.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    11. NM_001369724.1 → NP_001356653.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 5, 9-12, 14-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    12. NM_001369725.1 → NP_001356654.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 5, 9-13, 15-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    13. NM_001369726.1 → NP_001356655.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 5, 9-14, 16-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000497971.1, ENST00000650632.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    14. NM_001369727.1 → NP_001356656.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 5, 9-15, 17-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    15. NM_001369728.1 → NP_001356657.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 5, 9-16, 18-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000496867.1, ENST00000649876.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    16. NM_001369729.1 → NP_001356658.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 5, 9-17, 19-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    17. NM_001369730.1 → NP_001356659.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 5, 9-18, 20-22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    18. NM_001369731.1 → NP_001356660.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 5, 9-19, 21, 22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000498047.1, ENST00000649233.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    19. NM_001369732.1 → NP_001356661.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 5, 9-20, 22, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    20. NM_001369733.1 → NP_001356662.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 5, 9-21, and 30, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000498138.1, ENST00000649428.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    21. NM_001369734.1 → NP_001356663.1  paternally-expressed gene 3 protein isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 24-27, encodes isoform 6.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS92696.1
      UniProtKB/TrEMBL
      A0A3B3IRU6, B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1264 → 1348
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:352 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    22. NM_001369735.1 → NP_001356664.1  paternally-expressed gene 3 protein isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 23 and 25-27, encodes isoform 6.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS92696.1
      UniProtKB/TrEMBL
      A0A3B3IRU6, B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1264 → 1348
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:352 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    23. NM_001369736.1 → NP_001356665.1  paternally-expressed gene 3 protein isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 23, 24, 26, and 27, encodes isoform 6.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS92696.1
      UniProtKB/TrEMBL
      A0A3B3IRU6, B9EG68
      Related
      ENSP00000496853.1, ENST00000647621.1
      Conserved Domains (3) summary
      PHA03169
      Location:1264 → 1348
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:352 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    24. NM_001369737.1 → NP_001356666.1  paternally-expressed gene 3 protein isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 23-25 and 27, encodes isoform 6.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS92696.1
      UniProtKB/TrEMBL
      A0A3B3IRU6, B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1264 → 1348
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:352 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    25. NM_001369738.1 → NP_001356667.1  paternally-expressed gene 3 protein isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 23-26, encodes isoform 6.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS92696.1
      UniProtKB/TrEMBL
      A0A3B3IRU6, B9EG68
      Conserved Domains (3) summary
      PHA03169
      Location:1264 → 1348
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:352 → 372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:814 → 836
      zf-C2H2; Zinc finger, C2H2 type

    26. NM_001369739.1 → NP_001356668.1  paternally-expressed gene 3 protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 5 and 9-22, encodes isoform 3.
      Source sequence(s)
      AC006115
      Consensus CDS
      CCDS58684.1
      UniProtKB/TrEMBL
      B9EG68
      Related
      ENSP00000496914.1, ENST00000648694.1
      Conserved Domains (3) summary
      PHA03169
      Location:1295 → 1379
      PHA03169; hypothetical protein; Provisional
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:845 → 867
      zf-C2H2; Zinc finger, C2H2 type

    27. NM_006210.3 → NP_006201.1  paternally-expressed gene 3 protein isoform 1

      See identical proteins and their annotated locations for NP_006201.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AF208967, AI089069, AK295679, BC037330, CR933682
      Consensus CDS
      CCDS12948.1
      UniProtKB/Swiss-Prot
      A7E2B8, B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZU2, Q9GZY2
      UniProtKB/TrEMBL
      Q96Q96
      Related
      ENSP00000326581.7, ENST00000326441.15
      Conserved Domains (5) summary
      PHA00666
      Location:1421 → 1501
      PHA00666; putative protease
      sd00017
      Location:507 → 527
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:969 → 991
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:42 → 124
      SCAN; SCAN domain
      pfam08648
      Location:141 → 237
      DUF1777; Protein of unknown function (DUF1777)

    RNA

    1. NR_161475.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006115

    2. NR_161476.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006115

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      56810082..56840726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      59905167..59935794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001146186.1: Suppressed sequence

      Description
      NM_001146186.1: This RefSeq was removed because currently there is insufficient support for the 5' end of the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GZU2.1 GenPept UniProtKB/Swiss-Prot:Q9GZU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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