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    CCL14 C-C motif chemokine ligand 14 [ Homo sapiens (human) ]

    Gene ID: 6358, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CCL14provided by HGNC
    Official Full Name
    C-C motif chemokine ligand 14provided by HGNC
    Primary source
    HGNC:HGNC:10612
    See related
    Ensembl:ENSG00000276409 MIM:601392; AllianceGenome:HGNC:10612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1(1-74); HCC-1/HCC-3
    Summary
    This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
    Expression
    Broad expression in spleen (RPKM 229.5), fat (RPKM 134.4) and 15 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CCL14 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35983288..35986729, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36931192..36934633, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34310324..34313765, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene lysozyme like 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:34288003-34288221 Neighboring gene Sharpr-MPRA regulatory region 10414 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene uncharacterized LOC107985068 Neighboring gene C-C motif chemokine ligand 15 Neighboring gene C-C motif chemokine ligand 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chemokine CCL14 affected the clinical outcome and correlated with immune infiltrates in thyroid carcinoma. Zhang MM, et al. Histol Histopathol, 2023 Jun. PMID 36409028
    2. HCC-1, a novel chemokine from human plasma. Schulz-Knappe P, et al. J Exp Med, 1996 Jan 1. PMID 8551235, Free PMC Article
    3. CCL14 exacerbates intraplaque vulnerability by promoting neovascularization in the human carotid plaque. Li Z, et al. J Stroke Cerebrovasc Dis, 2022 Oct. PMID 35973397
    4. Posttranslationally processed forms of the human chemokine HCC-1. Richter R, et al. Biochemistry, 2000 Sep 5. PMID 10978165
    5. C-C motif chemokine ligand 14 inhibited colon cancer cell proliferation and invasion through suppressing M2 polarization of tumor-associated macrophages. Li N, et al. Histol Histopathol, 2021 Jul. PMID 34096611

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Performance of urinary C-C motif chemokine ligand 14 for the prediction of persistent acute kidney injury: a systematic review and meta-analysis.
      Title: Performance of urinary C-C motif chemokine ligand 14 for the prediction of persistent acute kidney injury: a systematic review and meta-analysis.
    2. Chemokine CCL14 affected the clinical outcome and correlated with immune infiltrates in thyroid carcinoma.
      Title: Chemokine CCL14 affected the clinical outcome and correlated with immune infiltrates in thyroid carcinoma.
    3. CCL14 exacerbates intraplaque vulnerability by promoting neovascularization in the human carotid plaque.
      Title: CCL14 exacerbates intraplaque vulnerability by promoting neovascularization in the human carotid plaque.
    4. C-C motif chemokine ligand 14 inhibited colon cancer cell proliferation and invasion through suppressing M2 polarization of tumor-associated macrophages.
      Title: C-C motif chemokine ligand 14 inhibited colon cancer cell proliferation and invasion through suppressing M2 polarization of tumor-associated macrophages.
    5. Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14.
      Title: Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14.
    6. Serum proteins TGFBI, PCSK9, and CCL14 are potential biomarkers for different traditional Chinese medicine syndromes of multidrug-resistant tuberculosis.
      Title: Serum proteins TGFBI, PCSK9, and CCL14 are potential biomarkers for different traditional Chinese medicine syndromes of multidrug-resistant tuberculosis.
    7. Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/beta-catenin pathway.
      Title: Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/β-catenin pathway.
    8. CCL14 expression in healthy human palatal mucosa is strongly negatively correlated with serum cotinine levels.
      Title: Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.
    9. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival
      Title: TMEM88, CCL14 and CLEC3B as prognostic biomarkers for prognosis and palindromia of human hepatocellular carcinoma.
    10. CCL2, 3, 14 have roles in stimulating macrophage bone marrow homing, proliferation, and polarization in multiple myeloma
      Title: Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-C motif) ligand 14 (CCL14) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough CCL15-CCL14

    Readthrough gene: CCL15-CCL14, Included gene: CCL15

    Homology

    Clone Names

    • FLJ16015

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C-C motif chemokine 14
    Names
    chemokine (C-C motif) ligand 14
    chemokine CC-1/CC-3
    chemokine CC-3
    hemofiltrate CC chemokine 1
    new CC chemokine 2
    small inducible cytokine subfamily A (Cys-Cys), member 14
    small-inducible cytokine A14

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032962.5 → NP_116738.1  C-C motif chemokine 14 isoform 2 precursor

      See identical proteins and their annotated locations for NP_116738.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as CCL14b) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AA612866, AC244100, BC045165, BI496964, DA821276
      Consensus CDS
      CCDS45652.1
      UniProtKB/Swiss-Prot
      Q16627
      Related
      ENSP00000479097.1, ENST00000622526.1
      Conserved Domains (1) summary
      smart00199
      Location:48 → 106
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    2. NM_032963.4 → NP_116739.1  C-C motif chemokine 14 isoform 1 precursor

      See identical proteins and their annotated locations for NP_116739.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, CCL14a) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. The resulting isoform (1) lacks an alternate segment near the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC244100, DA821276
      Consensus CDS
      CCDS32624.1
      UniProtKB/Swiss-Prot
      E1P649, E1P650, Q13954, Q16627
      Related
      ENSP00000481023.1, ENST00000618404.5
      Conserved Domains (1) summary
      smart00199
      Location:32 → 90
      SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35983288..35986729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      217852..221293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36931192..36934633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004166.4: Suppressed sequence

      Description
      NM_004166.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16627.1 GenPept UniProtKB/Swiss-Prot:Q16627

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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