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    P2RY1 purinergic receptor P2Y1 [ Homo sapiens (human) ]

    Gene ID: 5028, updated on 9-Dec-2024

    Summary

    Official Symbol
    P2RY1provided by HGNC
    Official Full Name
    purinergic receptor P2Y1provided by HGNC
    Primary source
    HGNC:HGNC:8539
    See related
    Ensembl:ENSG00000169860 MIM:601167; AllianceGenome:HGNC:8539
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P2Y1; SARCC
    Summary
    The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See P2RY1 in Genome Data Viewer
    Location:
    3q25.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (152835131..152841439)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (155605520..155611828)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (152552920..152559228)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124909449 Neighboring gene ATP synthase membrane subunit g pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20712 Neighboring gene Sharpr-MPRA regulatory region 13992 Neighboring gene uncharacterized LOC124909450 Neighboring gene MPRA-validated peak4863 silencer Neighboring gene MPRA-validated peak4864 silencer Neighboring gene CRISPRi-validated cis-regulatory element chr3.4520 Neighboring gene Sharpr-MPRA regulatory region 12497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14828 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 13

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Interaction of the HIV-1 gp120 with macrophages triggers an increase in ATP release that stimulates purinergic receptor P2X(1), P2X(7), and P2Y(1) proteins and facilitates HIV entry and subsequent stages of viral replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables A1 adenosine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled ADP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled ADP receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables G protein-coupled ATP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled ATP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled purinergic nucleotide receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables scaffold protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to ATP TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to purine-containing compound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of norepinephrine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inositol trisphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of penile erection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in relaxation of muscle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction involved in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface HDA PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    P2Y purinoceptor 1
    Names
    ADP receptor
    ATP receptor
    P2 purinoceptor subtype Y1
    platelet ADP receptor
    purinergic receptor P2Y, G-protein coupled, 1
    suppressing androgen receptor in renal cell carcinoma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032896.2 RefSeqGene

      Range
      5185..11493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_635

    mRNA and Protein(s)

    1. NM_002563.5NP_002554.1  P2Y purinoceptor 1

      See identical proteins and their annotated locations for NP_002554.1

      Status: REVIEWED

      Source sequence(s)
      AC013251, AK026659, DA396016, DA453416, U42030
      Consensus CDS
      CCDS3169.1
      UniProtKB/Swiss-Prot
      P47900
      UniProtKB/TrEMBL
      B2R9U4
      Related
      ENSP00000304767.3, ENST00000305097.6
      Conserved Domains (1) summary
      cd15377
      Location:52335
      7tmA_P2Y1; P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      152835131..152841439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      155605520..155611828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)