DAPK1 death associated protein kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DAPK1provided by HGNC
Official Full Name: death associated protein kinase 1provided by HGNC
Primary source: HGNC:HGNC:2674
See related: Ensembl:ENSG00000196730 MIM:600831; AllianceGenome:HGNC:2674
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DAPK; ROCO3
Summary: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression: Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q21.33

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (87497228..87708634)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (99650695..99862240)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (90112143..90323549)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Death associated protein kinase 1 predicts the prognosis and the immunotherapy response of various cancers.
Title: Death associated protein kinase 1 predicts the prognosis and the immunotherapy response of various cancers.
Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia.
Title: Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia.
Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis.
Title: Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis.
The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells.
Title: The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells.
BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.
Title: BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.
Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function.
Title: Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function.
Knockdown of DAPK1 inhibits IL-1beta-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-kappaB and NLRP3 inflammasome pathway.
Title: Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathway.
Diagnostic value of the combination of DAPK methylation in urinary sediment and B ultrasound for recurrent urinary bladder cancer.
Title: Diagnostic value of the combination of DAPK methylation in urinary sediment and B ultrasound for recurrent urinary bladder cancer.
NMDA Receptor GluN2B Subunit Is Involved in Excitotoxicity Mediated by Death-Associated Protein Kinase 1 in Alzheimer's Disease.
Title: NMDA Receptor GluN2B Subunit Is Involved in Excitotoxicity Mediated by Death-Associated Protein Kinase 1 in Alzheimer's Disease.
MiR-191-5p Attenuates Tau Phosphorylation, Abeta Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1.
Title: MiR-191-5p Attenuates Tau Phosphorylation, Aβ Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1.

Submit: New GeneRIF Correction See all GeneRIFs (235)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Heritability and genetic association analysis of cognition in the&#x000a0;Diabetes Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-148843 (e-PCR)
- UniSTS:176641

SHGC-84082 (e-PCR)
- UniSTS:104728

D9S2045 (e-PCR)
- UniSTS:13338

D9S316 (e-PCR)
- UniSTS:153124

RH69306 (e-PCR)
- UniSTS:67367

SHGC-33610 (e-PCR)
- UniSTS:5933

RH18220 (e-PCR)
- UniSTS:21550

SHGC-146783 (e-PCR)
- UniSTS:175427

STS-X76104 (e-PCR)
- UniSTS:51017

STS-N34470 (e-PCR)
- UniSTS:79970

D9S257 (e-PCR)
- UniSTS:8048

DAPK1 (e-PCR)
- UniSTS:505968

SHGC-149458 (e-PCR)
- UniSTS:177018

SHGC-2351 (e-PCR)
- UniSTS:46760

G59619 (e-PCR)
- UniSTS:136922

WI-17027 (e-PCR)
- UniSTS:27104

RH45604 (e-PCR)
- UniSTS:54498

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables syntaxin-1 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydroperoxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of NMDA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of autophagy	TAS Traceable Author Statement more info	PubMed
involved_in regulation of response to tumor cell	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of DAPK1-calmodulin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: death-associated protein kinase 1

Names: DAP kinase 1

NP_001275658.1

EC 2.7.11.1

NP_001275659.1

EC 2.7.11.1

NP_001275660.1

EC 2.7.11.1

NP_004929.2

EC 2.7.11.1

XP_005251814.1

EC 2.7.11.1

XP_016869849.1

EC 2.7.11.1

XP_047278842.1

EC 2.7.11.1

XP_047278843.1

EC 2.7.11.1

XP_047278844.1

EC 2.7.11.1

XP_054218179.1

EC 2.7.11.1

XP_054218180.1

EC 2.7.11.1

XP_054218181.1

EC 2.7.11.1

XP_054218182.1

EC 2.7.11.1

XP_054218183.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029883.1 RefSeqGene

Range

5027..215794

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001288729.2 → NP_001275658.1 death-associated protein kinase 1

See identical proteins and their annotated locations for NP_001275658.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AA854055, AL160279, BC113660, BP202018, CD642694, CN347006, CX758421, DA234399, DA855348, H77515

Consensus CDS

CCDS43842.1

UniProtKB/Swiss-Prot

B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

UniProtKB/TrEMBL

B4DHI4

Related

ENSP00000484267.1, ENST00000622514.4

Conserved Domains (5) summary

PLN03192
Location:515 → 768

PLN03192; Voltage-dependent potassium channel; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

cl39094
Location:367 → 639

Ank_2; Ankyrin repeats (3 copies)
NM_001288730.2 → NP_001275659.1 death-associated protein kinase 1

See identical proteins and their annotated locations for NP_001275659.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AB208871, BC113660, BC143733, DC340223, H77515

Consensus CDS

CCDS43842.1

UniProtKB/Swiss-Prot

B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

UniProtKB/TrEMBL

B4DHI4

Related

ENSP00000417076.1, ENST00000472284.5

Conserved Domains (5) summary

PLN03192
Location:515 → 768

PLN03192; Voltage-dependent potassium channel; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

cl39094
Location:367 → 639

Ank_2; Ankyrin repeats (3 copies)
NM_001288731.2 → NP_001275660.1 death-associated protein kinase 1

See identical proteins and their annotated locations for NP_001275660.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AL160279, AL161787, AL591852, BC113660, H77515

Consensus CDS

CCDS43842.1

UniProtKB/Swiss-Prot

B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

UniProtKB/TrEMBL

B4DHI4

Related

ENSP00000350785.5, ENST00000358077.9

Conserved Domains (5) summary

PLN03192
Location:515 → 768

PLN03192; Voltage-dependent potassium channel; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

cl39094
Location:367 → 639

Ank_2; Ankyrin repeats (3 copies)
NM_004938.4 → NP_004929.2 death-associated protein kinase 1

See identical proteins and their annotated locations for NP_004929.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AK295119, BC113660, BG110813, CX872304, DR002874, H77515

Consensus CDS

CCDS43842.1

UniProtKB/Swiss-Prot

B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

UniProtKB/TrEMBL

B4DHI4

Related

ENSP00000386135.3, ENST00000408954.8

Conserved Domains (5) summary

PLN03192
Location:515 → 768

PLN03192; Voltage-dependent potassium channel; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

cl39094
Location:367 → 639

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

87497228..87708634

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422887.1 → XP_047278843.1 death-associated protein kinase 1 isoform X1

UniProtKB/Swiss-Prot

B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
XM_047422886.1 → XP_047278842.1 death-associated protein kinase 1 isoform X1

UniProtKB/Swiss-Prot

B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
XM_005251757.5 → XP_005251814.1 death-associated protein kinase 1 isoform X3

Conserved Domains (6) summary

smart00220
Location:13 → 275

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00204
Location:505 → 629

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

pfam12796
Location:449 → 541

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:347 → 399

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]
XM_047422888.1 → XP_047278844.1 death-associated protein kinase 1 isoform X4
XM_017014360.2 → XP_016869849.1 death-associated protein kinase 1 isoform X2