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    TIAM1 TIAM Rac1 associated GEF 1 [ Homo sapiens (human) ]

    Gene ID: 7074, updated on 27-Nov-2024

    Summary

    Official Symbol
    TIAM1provided by HGNC
    Official Full Name
    TIAM Rac1 associated GEF 1provided by HGNC
    Primary source
    HGNC:HGNC:11805
    See related
    Ensembl:ENSG00000156299 MIM:600687; AllianceGenome:HGNC:11805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDLDS; TIAM-1
    Summary
    This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
    Expression
    Broad expression in esophagus (RPKM 7.7), skin (RPKM 6.8) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TIAM1 in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (31118418..31559087, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (29486163..29927068, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (32490736..32931400, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_61959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18351 Neighboring gene keratin associated protein 19-8 Neighboring gene ubiquitin protein ligase E3A pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18353 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:32530991-32531520 Neighboring gene Sharpr-MPRA regulatory region 15669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:32554821-32555320 Neighboring gene uncharacterized LOC105372777 Neighboring gene MPRA-validated peak4402 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:32710674-32711873 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:32738744-32739943 Neighboring gene MPRA-validated peak4404 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr21:32822900-32823113 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:32842913-32843876 Neighboring gene MTRES1 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32867589-32868090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32868091-32868590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:32894311-32894810 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr21:32917456-32918188 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32925735-32926454 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:32926455-32927174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:32929546-32930359 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32931173-32931985 Neighboring gene TIAM1 antisense RNA 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:32955714-32956498 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:32956499-32957283 Neighboring gene MPRA-validated peak4405 silencer Neighboring gene uncharacterized LOC107985488

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with language delay and seizures
    MedGen: C5676998 OMIM: 619908 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
    EBI GWAS Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ36302

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Rac protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in neuron projection extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Schwann cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of dendritic spine morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial to mesenchymal transition NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopaminergic neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of non-canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axonal growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extrinsic component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in main axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor TIAM1
    Names
    T cell lymphoma invasion and metastasis 1
    T-lymphoma invasion and metastasis-inducing protein 1
    human T-lymphoma invasion and metastasis inducing TIAM1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353684.2NP_001340613.1  rho guanine nucleotide exchange factor TIAM1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000246
      Consensus CDS
      CCDS86983.1
      UniProtKB/TrEMBL
      A0A1B0GW57
      Related
      ENSP00000490786.1, ENST00000636887.1
      Conserved Domains (2) summary
      smart00325
      Location:77266
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:268439
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    2. NM_001353685.2NP_001340614.1  rho guanine nucleotide exchange factor TIAM1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP000246
      Conserved Domains (2) summary
      smart00325
      Location:52241
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01255
      Location:243414
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    3. NM_001353686.2NP_001340615.1  rho guanine nucleotide exchange factor TIAM1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248
      Conserved Domains (5) summary
      cd01818
      Location:766841
      TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
      smart00325
      Location:10191208
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12101381
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    4. NM_001353687.2NP_001340616.1  rho guanine nucleotide exchange factor TIAM1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248
      Related
      ENSP00000388217.2, ENST00000455508.2
      Conserved Domains (5) summary
      cd01818
      Location:741816
      TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
      smart00325
      Location:10191208
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:821900
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12101381
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    5. NM_001353688.1NP_001340617.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    6. NM_001353689.1NP_001340618.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    7. NM_001353690.1NP_001340619.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    8. NM_001353691.1NP_001340620.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    9. NM_001353692.1NP_001340621.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    10. NM_001353693.1NP_001340622.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    11. NM_001353694.2NP_001340623.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Related
      ENSP00000441570.2, ENST00000541036.6
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    12. NM_003253.3NP_003244.2  rho guanine nucleotide exchange factor TIAM1 isoform 1

      See identical proteins and their annotated locations for NP_003244.2

      Status: REVIEWED

      Source sequence(s)
      AP000246, AP000247, AP000248, AP000251, AP000563
      Consensus CDS
      CCDS13609.1
      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
      Related
      ENSP00000286827.3, ENST00000286827.7
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam02196
      Location:766835
      RBD; Raf-like Ras-binding domain
      pfam18385
      Location:572669
      Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      31118418..31559087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440969.1XP_047296925.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

      UniProtKB/Swiss-Prot
      B7ZLR6, F5GZ53, Q13009, Q17RT7
      UniProtKB/TrEMBL
      A0A2X0TW27
    2. XM_005261040.3XP_005261097.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TN84
      Related
      ENSP00000513591.1, ENST00000698169.1
      Conserved Domains (6) summary
      smart00325
      Location:10441233
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:846925
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01230
      Location:432558
      PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
      cd01255
      Location:12351406
      PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
      pfam00169
      Location:445547
      PH; PH domain
      cl00155
      Location:766841
      UBQ; Ubiquitin-like proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      29486163..29927068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324807.1XP_054180782.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    2. XM_054324808.1XP_054180783.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TN84