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    SPRR2B small proline rich protein 2B [ Homo sapiens (human) ]

    Gene ID: 6701, updated on 27-Nov-2024

    Summary

    Official Symbol
    SPRR2Bprovided by HGNC
    Official Full Name
    small proline rich protein 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:11262
    See related
    Ensembl:ENSG00000196805 MIM:182268; AllianceGenome:HGNC:11262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in keratinization. Predicted to act upstream of or within response to estradiol. Predicted to be located in cornified envelope and cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward esophagus (RPKM 318.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SPRR2B in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153070226..153087799, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152206987..152208372, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153042702..153044087, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small proline rich protein 2D Neighboring gene small proline rich protein 2A Neighboring gene small proline rich protein 2E Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:153072092-153073291 Neighboring gene small proline rich protein 2F

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in epidermis development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cornified envelope NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cornified envelope TAS
    Traceable Author Statement
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    small proline-rich protein 2B
    Names
    SPR-2B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017418.3NP_001017418.1  small proline-rich protein 2B

      See identical proteins and their annotated locations for NP_001017418.1

      Status: VALIDATED

      Source sequence(s)
      AL139417, AL356867, BF090370, CA311074
      Consensus CDS
      CCDS30865.1
      UniProtKB/Swiss-Prot
      P35325, Q5T528
    2. NM_001388198.1NP_001375127.1  small proline-rich protein 2B

      Status: VALIDATED

      Source sequence(s)
      AL139417, AL356867
      Consensus CDS
      CCDS30865.1
      UniProtKB/Swiss-Prot
      P35325, Q5T528
      Related
      ENSP00000357744.1, ENST00000368755.3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      153070226..153087799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428866.1XP_047284822.1  small proline-rich protein 2B isoform X1

      UniProtKB/Swiss-Prot
      P35325, Q5T528

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      152206987..152208372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)