| Altered fibrinogen gamma-chain cross-linking in mutant fibrinogen-gamma[Delta5] mice drives acute liver injury. | Altered fibrinogen γ-chain cross-linking in mutant fibrinogen-γ(Δ5) mice drives acute liver injury.
Poole LG, Schmitt LR, Schulte A, Groeneveld DJ, Cline HM, Sang Y, Hur WS, Wolberg AS, Flick MJ, Hansen KC, Luyendyk JP., Free PMC Article | 09/12/2023 |
| Elimination of fibrin gamma-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi. | Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.
Duval C, Baranauskas A, Feller T, Ali M, Cheah LT, Yuldasheva NY, Baker SR, McPherson HR, Raslan Z, Bailey MA, Cubbon RM, Connell SD, Ajjan RA, Philippou H, Naseem KM, Ridger VC, Ariëns RAS., Free PMC Article | 12/4/2021 |
| These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations. | The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
Byrnes JR, Wilson C, Boutelle AM, Brandner CB, Flick MJ, Philippou H, Wolberg AS., Free PMC Article | 08/5/2017 |
| Report role of gamma'-fibrinogen in control of hemostatic clot growth in the venous circulation. | Fibrin, γ'-fibrinogen, and transclot pressure gradient control hemostatic clot growth during human blood flow over a collagen/tissue factor wound.
Muthard RW, Welsh JD, Brass LF, Diamond SL., Free PMC Article | 04/16/2016 |
| Fibrinogen from mice harboring the Fibgamma390-396A mutation exhibited reduced binding to FXIII, and plasma from these mice exhibited delayed FXIII activation and fibrin crosslinking, indicating these residues mediate FXIII binding and activation. | Factor XIII activity mediates red blood cell retention in venous thrombi.
Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Di Paola J, Mackman N, Degen JL, Flick MJ, Wolberg AS., Free PMC Article | 02/21/2015 |
| elevated levels of gammaA/gammaA fibrinogen promote arterial thrombosis in vivo, whereas gammaA/gamma' does not | The fibrinogen γA/γ' isoform does not promote acute arterial thrombosis in mice.
Walton BL, Getz TM, Bergmeier W, Lin FC, Uitte de Willige S, Wolberg AS., Free PMC Article | 01/31/2015 |
| the gamma'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke | γ'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke.
van den Herik EG, Cheung EY, de Lau LM, den Hertog HM, Leebeek FW, Dippel DW, Koudstaal PJ, de Maat MP. | 06/25/2011 |
| smaller thrombi result from the ability of fibrin to bind and sequester thrombin and/or the ability of the altered fibrinogen molecules, which cannot recruit platelets, to bind to and passivate the surface. | Antibody blockade or mutation of the fibrinogen gamma-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen.
Jirousková M, Chereshnev I, Väänänen H, Degen JL, Coller BS. | 01/21/2010 |
| The Studies have shown that gamma chain binding to thrombin and factor XIII results in clots that are mechanically stiffer and resistant to fibrinolysis, which may explain the association between gammaA/gamma' fibrinogen levels and cardiovascular disease. | Pathophysiologic roles of the fibrinogen gamma chain.
Farrell DH. | 01/21/2010 |
| Platelet receptor engagement of the Fgg chain contributes to the stable incorporation of platelets into thrombi. Fibrinogen is internalized through alpha IIb beta 3 engagement of the Fgg chain; this interaction controls fibronectin content of platelets. | Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain.
Ni H, Papalia JM, Degen JL, Wagner DD. | 01/21/2010 |
| the engagement of alphaIIb beta3 by the C-terminal sequence of the fibrinogen gamma-chain initiates signals that suppress subsequent fibronectin assembly by spread platelets | Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain.
Cho J, Degen JL, Coller BS, Mosher DF. | 01/21/2010 |