| Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress. | Cell division cyclin 25C knockdown inhibits hepatocellular carcinoma development by inducing endoplasmic reticulum stress.
Li YF, Zheng FY, Miao XY, Liu HL, Zhang YY, Chao NX, Mo FR., Free PMC Article | 08/26/2024 |
| KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway. | KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway.
Zhai M, Miao J, Zhang R, Liu R, Li F, Shen Y, Wang T, Xu X, Gao G, Hu J, He A, Bai J., Free PMC Article | 06/3/2024 |
| PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C. | PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C.
Xu N, Ren Y, Bao Y, Shen X, Kang J, Wang N, Wang Z, Han X, Li Z, Zuo J, Wei GH, Wang Z, Zong WX, Liu W, Xie G, Wang Y. | 10/11/2023 |
| CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma. | CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma.
Zhou C, Wang L, Hu W, Tang L, Zhang P, Gao Y, Du J, Li Y, Wang Y., Free PMC Article | 06/11/2022 |
| Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer. | Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer.
Topno R, Nazam N, Kumari P, Kumar M, Agarwal P. | 05/21/2022 |
| CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival. | CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival.
Galusic D, Lucijanic M, Livun A, Radman M, Lucijanic J, Drmic Hofman I, Kusec R. | 02/12/2022 |
| Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis. | Identification of Prognostic Genes for Colon Cancer through Gene Co-expression Network Analysis.
Wang DW, Yang ZS, Xu J, Yang LJ, Yang TC, Wang HQ, Feng MH, Su F. | 02/5/2022 |
| Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress. | Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.
Herbert KJ, Puliyadi R, Prevo R, Rodriguez-Berriguete G, Ryan A, Ramadan K, Higgins GS., Free PMC Article | 01/29/2022 |
| Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis. | Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis.
Xun R, Lu H, Wang X., Free PMC Article | 11/6/2021 |
| BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer. | BTNL9 is frequently downregulated and inhibits proliferation and metastasis via the P53/CDC25C and P53/GADD45 pathways in breast cancer.
Mo Q, Xu K, Luo C, Zhang Q, Wang L, Ren G. | 07/10/2021 |
| Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells. | Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells.
Liu K, Zheng M, Zhao Q, Zhang K, Li Z, Fu F, Zhang H, Du J, Li Y, Zhang S., Free PMC Article | 02/6/2021 |
| Studied p38MAPK-ERK-JNK-cell division cycle 25C (CDC25C) expression in polyploid giant cancer cells and clinicopathological significance of p38MAPK, ERK, JNK, and CDC25C expression in human ovarian and breast cancers. | Association and clinicopathologic significance of p38MAPK-ERK-JNK-CDC25C with polyploid giant cancer cell formation.
Liu K, Lu R, Zhao Q, Du J, Li Y, Zheng M, Zhang S. | 05/2/2020 |
| Increased expression of CDC25B or CDC25C are mechanisms by which skin cancers evade apoptotic cell death. | CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.
Al-Matouq J, Holmes TR, Hansen LA. | 11/16/2019 |
| AMPK directly phosphorylates CDC25C on serine 216, a well-conserved inhibitory phosphorylation event, which has been shown to mediate DNA damage-induced G2-phase arrest. The acute induction of CDC25C or suppression of WEE1 partially restores mitosis entry in the context of AMPK activation. | Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G(2)/M-phase transition.
Shen Y, Sherman JW, Chen X, Wang R., Free PMC Article | 01/12/2019 |
| Cells lacking ARID1A show enhanced AURKA transcription, which leads to the persistent activation of CDC25C, a key protein for G2/M transition and mitotic entry. | Targeting AURKA-CDC25C axis to induce synthetic lethality in ARID1A-deficient colorectal cancer cells.
Wu C, Lyu J, Yang EJ, Liu Y, Zhang B, Shim JS., Free PMC Article | 12/29/2018 |
| FHL1 increase inhibitory CDC25 phosphorylation by forming a complex with CHK2 and CDC25, and sequester CDC25 in the cytoplasm by forming another complex with 14-3-3 and CDC25, resulting in increased radioresistance in cancer cells. | A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.
Xu X, Fan Z, Liang C, Li L, Wang L, Liang Y, Wu J, Chang S, Yan Z, Lv Z, Fu J, Liu Y, Jin S, Wang T, Hong T, Dong Y, Ding L, Cheng L, Liu R, Fu S, Jiao S, Ye Q., Free PMC Article | 11/17/2018 |
| Overexpression of the CDK1 and CDC25A may have a role in the pathogenesis of the NFPA. | Systematic Investigation of Expression of G2/M Transition Genes Reveals CDC25 Alteration in Nonfunctioning Pituitary Adenomas.
Butz H, Németh K, Czenke D, Likó I, Czirják S, Zivkovic V, Baghy K, Korbonits M, Kovalszky I, Igaz P, Rácz K, Patócs A. | 03/24/2018 |
| Mdm2 overexpression and Cdc25C downregulation delay cell cycle progression through the G2/M phase. | Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase.
Giono LE, Resnick-Silverman L, Carvajal LA, St Clair S, Manfredi JJ., Free PMC Article | 12/23/2017 |
| Xanthatin functions as a DNA-damaging agent in non-small cell lung carcinomas by activating Chk1-mediated DDR and lysosome-mediated degradation of Cdc25C. | Xanthatin triggers Chk1-mediated DNA damage response and destabilizes Cdc25C via lysosomal degradation in lung cancer cells.
Tao L, Cao Y, Wei Z, Jia Q, Yu S, Zhong J, Wang A, Woodgett JR, Lu Y. | 12/16/2017 |
| Myelodysplastic syndrome -related P95 point mutants of SRSF2 lead to alternative splicing of CDC25C in a manner that is not dependent on the DNA damage response. | Myelodysplasia-associated mutations in serine/arginine-rich splicing factor SRSF2 lead to alternative splicing of CDC25C.
Skrdlant L, Stark JM, Lin RJ., Free PMC Article | 09/16/2017 |
| The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma. | Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrences.
Dedobbeleer M, Willems E, Freeman S, Lombard A, Goffart N, Rogister B. | 08/19/2017 |
| Data show that TRIB2-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 kinase-like domain. | Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C.
Liang KL, Paredes R, Carmody R, Eyers PA, Meyer S, McCarthy TV, Keeshan K., Free PMC Article | 05/6/2017 |
| High expression of pCHK2-Thr68 was associated with decreased patient survival (p = 0.001), but was not an independent prognostic factor. Our results suggest that pCHK2-Thr68 and pCDC25C-Ser216 play important roles in breast cancer and may be potential treatment targets | The Expression and Clinical Outcome of pCHK2-Thr68 and pCDC25C-Ser216 in Breast Cancer.
Jiang H, Wang B, Zhang F, Qian Y, Chuang CC, Ying M, Wang Y, Zuo L., Free PMC Article | 04/1/2017 |
| the biology of the activation/deactivation of CDC25 by kinases/phosphatases to maintain the level of CDK-cyclin activities and thus the genomic stability | Phosphatases and kinases regulating CDC25 activity in the cell cycle: clinical implications of CDC25 overexpression and potential treatment strategies.
Sur S, Agrawal DK., Free PMC Article | 02/18/2017 |
| the knockdown of CDC25C can reduce both the radiotherapy sensitivity and the proliferation activity of EC9706 cells. | Downregulation of cell division cycle 25 homolog C reduces the radiosensitivity and proliferation activity of esophageal squamous cell carcinoma.
Yin Y, Dou X, Duan S, Zhang L, Xu Q, Li H, Li D. | 02/4/2017 |