| Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis. | Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis.
Arnold KM, Weaver SR, Zars EL, Tschumperlin DJ, Westendorf JJ., | 06/8/2024 |
| Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling. | Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.
Qiu Y, Meng Y, Jia Y, Lang X, Zhao H, Ding L, Wang T, Sun H, Gao S. | 12/18/2023 |
| PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble. | PHLPP isoforms differentially regulate Akt isoforms and AS160 affecting neuronal insulin signaling and insulin resistance via Scribble.
Sharma M, Dey CS., Free PMC Article | 11/26/2022 |
| CircRNA_45478 promotes ischemic AKI by targeting the miR-190a-5p/PHLPP1 axis. | CircRNA_45478 promotes ischemic AKI by targeting the miR-190a-5p/PHLPP1 axis.
Liao Y, Peng X, Li X, Wu D, Qiu S, Tang X, Zhang D. | 11/5/2022 |
| Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes. | Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A., Free PMC Article | 02/12/2022 |
| Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth. | Pleckstrin homology (PH) domain and Leucine Rich Repeat Phosphatase 1 (Phlpp1) Suppresses Parathyroid Hormone Receptor 1 (Pth1r) Expression and Signaling During Bone Growth.
Weaver SR, Taylor EL, Zars EL, Arnold KM, Bradley EW, Westendorf JJ., Free PMC Article | 09/18/2021 |
| Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice. | Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice.
Zhang C, Smith MP, Zhou GK, Lai A, Hoy RC, Mroz V, Torre OM, Laudier DM, Bradley EW, Westendorf JJ, Iatridis JC, Illien-Jünger S., Free PMC Article | 08/22/2020 |
| CXCL13 is an adipocytokine that facilitates hypoxia-induced inflammation in adipocytes through FAK-mediated induction of PHLPP1 in autocrine and/or paracrine manner. | CXCL13 is a differentiation- and hypoxia-induced adipocytokine that exacerbates the inflammatory phenotype of adipocytes through PHLPP1 induction.
Kusuyama J, Bandow K, Ohnishi T, Amir MS, Shima K, Semba I, Matsuguchi T. | 07/11/2020 |
| Phlpp1 deficiency increases activity of PKCzeta, a PKC isoform controlling cell polarity, and that addition of a PKCzeta pseudosubstrate restores osteoclastogenesis and bone resorption of Phlpp1-deficient osteoclasts. Moreover, Phlpp1 deficiency increased expression of the bone-coupling factor collagen triple helix repeat-containing 1 (Cthrc1) | Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice.
Mattson AM, Begun DL, Molstad DHH, Meyer MA, Oursler MJ, Westendorf JJ, Bradley EW., Free PMC Article | 03/21/2020 |
| Investigation of PHLPP1 function in macrophages reveals that it controls the magnitude and duration of inflammatory signaling by dephosphorylating the transcription factor STAT1 on Ser727 to inhibit its activity, reduce its promoter residency, and reduce the expression of target genes involved in innate immunity and cytokine signaling. | PHLPP1 counter-regulates STAT1-mediated inflammatory signaling.
Cohen Katsenelson K, Stender JD, Kawashima AT, Lordén G, Uchiyama S, Nizet V, Glass CK, Newton AC., Free PMC Article | 02/1/2020 |
| FoxO3a transcription factor regulates PHLPP1 expression in chondrocytes. The crucial role of DNA methylation in controlling PHLPP1 transcription is also supported. | DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes.
Castillejo Becerra CM, Mattson AM, Molstad DHH, Lorang IM, Westendorf JJ, Bradley EW., Free PMC Article | 10/19/2019 |
| Consistent with an important role of SCOP/PHLPP1 on memory function, injured-KOs had near normal performance on the probe trial of the Morris water maze, whereas injured-WTs were impaired. CA1/CA3 hippocampal survival was lower in KOs vs. WTs 24 h post-injury but equivalent by 7d. | Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice.
Jackson TC, Dixon CE, Janesko-Feldman K, Vagni V, Kotermanski SE, Jackson EK, Kochanek PM., Free PMC Article | 10/12/2019 |
| Transfection with either a mimic or an inhibitor of miR-29b-1-5p confirmed that downregulation of PHLPP1 upregulates Akt-dependent NF-kappaB signalling leading to activation of matrix metalloproteinases 2 and 9, players in the degradation of extracellular matrix during Helicobacter pylori infection. | Genome-wide mRNA-miRNA profiling uncovers a role of the microRNA miR-29b-1-5p/PHLPP1 signalling pathway in Helicobacter pylori-driven matrix metalloproteinase production in gastric epithelial cells.
Datta C, Subuddhi A, Kumar M, Lepcha TT, Chakraborty S, Jana K, Ghosh Z, Mukhopadhyay AK, Basu J, Kundu M. | 07/20/2019 |
| Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury. | Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice.
Shao Z, Lv G, Wen P, Cao Y, Yu D, Lu Y, Li G, Su Z, Teng P, Gao K, Wang Y, Mei X. | 10/20/2018 |
| TNF-alpha is involved in cardiac PHLPP1 upregulation during reoxygenation, which is mediated by NF-kappaB transcriptional activity | Tumor necrosis factor-alpha upregulated PHLPP1 through activating nuclear factor-kappa B during myocardial ischemia/reperfusion.
Tang B, Ma J, Ha X, Zhang Y, Xing Y. | 09/22/2018 |
| the circadian expression of SCOP in the basolateral amygdala plays a key role in generating circadian rhythmicity in the anxiety-like behavior. | SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior.
Nakano JJ, Shimizu K, Shimba S, Fukada Y., Free PMC Article | 06/9/2018 |
| Results strengthen the roles of both calpain-1 and PHLPP1 in synaptic plasticity and learning and memory, and illustrate the complexities of the interactions between multiple pathways participating in synaptic plasticity. | Deleting both PHLPP1 and CANP1 rescues impairments in long-term potentiation and learning in both single knockout mice.
Liu Y, Sun J, Wang Y, Lopez D, Tran J, Bi X, Baudry M., Free PMC Article | 01/20/2018 |
| PHLPP1 reduced IFN-gamma-stimulated but not LPS-induced ERK1/2 phosphorylation, and inhibition of ERK1/2 abolished IFN-gamma-induced ser(727) STAT1 phosphorylation and iNOS expression. | A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages.
Alamuru NP, Behera S, Butchar JP, Tridandapani S, Kaimal Suraj S, Babu PP, Hasnain SE, Ehtesham NZ, Parsa KV. | 10/7/2017 |
| results identify a novel role of PHLPP in regulating aPKC and cell polarity. | Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.
Xiong X, Li X, Wen YA, Gao T., Free PMC Article | 05/27/2017 |
| Phlpp1 deficiency increases Akt2 activity, which diminishes FoxO1 levels and induces Fgf18 expression to stimulate chondrocyte proliferation. | Deletion of the PH-domain and Leucine-rich Repeat Protein Phosphatase 1 (Phlpp1) Increases Fibroblast Growth Factor (Fgf) 18 Expression and Promotes Chondrocyte Proliferation.
Bradley EW, Carpio LR, Newton AC, Westendorf JJ., Free PMC Article | 10/3/2015 |
| enhancing Akt activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy | Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy.
Moc C, Taylor AE, Chesini GP, Zambrano CM, Barlow MS, Zhang X, Gustafsson ÅB, Purcell NH., Free PMC Article | 10/3/2015 |
| data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs. | Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.
Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC., Free PMC Article | 04/25/2015 |
| SRPK1 overexpression is also tumorigenic because excess SRPK1 squelches PHLPP1. | Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.
Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, Fu XD., Free PMC Article | 07/26/2014 |
| PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. | PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Li X, Stevens PD, Liu J, Yang H, Wang W, Wang C, Zeng Z, Schmidt MD, Yang M, Lee EY, Gao T., Free PMC Article | 06/7/2014 |
| Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion | Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion.
Bradley EW, Carpio LR, Westendorf JJ., Free PMC Article | 06/1/2013 |