| The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis. | The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis.
Gajewska KA, Jans DA, Wagstaff KM., Free PMC Article | 02/11/2023 |
| Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response. | Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response.
Gajewska KA, Lescesen H, Ramialison M, Wagstaff KM, Jans DA., Free PMC Article | 11/6/2021 |
| Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation. | Importin 13 promotes NSCLC progression by mediating RFPL3 nuclear translocation and hTERT expression upregulation.
Zohud BA, Guo P, Zohud BA, Li F, Hao JJ, Shan X, Yu W, Guo W, Qin Y, Cai X., Free PMC Article | 05/15/2021 |
| This study reports the identification of mutation (c.331C>T, p.R111C) in the IPO13 gene in a consanguineous family with ocular coloboma, microphthalmia, and cataract by a combination of whole-exome sequencing and homozygosity mapping. | Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract.
Huang XF, Xiang L, Cheng W, Cheng FF, He KW, Zhang BW, Zheng SS, Han RY, Zheng YH, Xu XT, Yu HY, Zhuang W, Leung YF, Jin ZB., Free PMC Article | 04/25/2020 |
| this study significantly expands the repertoire of importin 13 cargoes and sets the basis for a more detailed characterization of this extremely versatile transport receptor. | Extensive Identification and In-depth Validation of Importin 13 Cargoes.
Baade I, Spillner C, Schmitt K, Valerius O, Kehlenbach RH., Free PMC Article | 05/4/2019 |
| This is the first report that IPO13 can be phosphorylated at Ser193 and that this modification regulates IPO13 subcellular localization and nucleocytoplasmic transport function, with important implications for IPO13's role in development and other processes. | PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function.
Liu X, Lin W, Shi X, Davies RG, Wagstaff KM, Tao T, Jans DA. | 04/6/2019 |
| The anti- glucocorticoid receptor effect of respiratory syncytial virus was mediated by viral nonstructural protein 1, which likely functioned by competing with IPO13 for glucocorticoid receptor binding. | Respiratory Syncytial Virus Nonstructural Protein 1 Blocks Glucocorticoid Receptor Nuclear Translocation by Targeting IPO13 and May Account for Glucocorticoid Insensitivity.
Xie J, Long X, Gao L, Chen S, Zhao K, Li W, Zhou N, Zang N, Deng Y, Ren L, Wang L, Luo Z, Tu W, Zhao X, Fu Z, Xie X, Liu E. | 03/30/2019 |
| IPO13 influenced intracellular distribution of CTCF. | CCCTC-binding factor controls its own nuclear transport via regulating the expression of importin 13.
Wang R, Shen J, Huang P, Zhu X., Free PMC Article | 02/1/2014 |
| IPO13 may contribute to the pathogenesis of pterygium via modulation of K17 and c-Jun. | Increased importin 13 activity is associated with the pathogenesis of pterygium.
Xu K, Tao T, Jie J, Lu X, Li X, Mehmood MA, He H, Liu Z, Xiao X, Yang J, Ma JX, Li W, Zhou Y, Liu Z., Free PMC Article | 09/28/2013 |
| Imp13 is able to bind and export eIF1A in vivo and that its function is essential. | Structural basis for the nuclear export activity of Importin13.
Grünwald M, Lazzaretti D, Bono F., Free PMC Article | 05/18/2013 |
| These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma. | Increased expression of importin13 in endometriosis and endometrial carcinoma.
Zeng B, Hu J, Yuan R, Hu L, Zhong L, Kang K., Free PMC Article | 09/29/2012 |
| Data show that expression of IPO13, c-kit, telomerase, caspase3, and CD146 are decreased in endometrial polyps; however, the expression of bcl-2 was increased in polyps compared to the normal endometrial tissue. | The expression levels of stem cell markers importin13, c-kit, CD146, and telomerase are decreased in endometrial polyps.
Hu J, Yuan R., Free PMC Article | 11/26/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| IPO13 is uniquely expressed by human limbal basal epithelial cells, and plays an important role in maintaining the phenotype, high proliferative potential, and less differentiation of corneal epithelial progenitor cells. | Importin 13 serves as a potential marker for corneal epithelial progenitor cells.
Wang H, Tao T, Tang J, Mao YH, Li W, Peng J, Tan G, Zhou YP, Zhong JX, Tseng SC, Kawakita T, Zhao YX, Liu ZG., Free PMC Article | 04/12/2010 |
| IPO13 variation may improve nuclear bioavailability of endogenous glucocorticoids | Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma.
Raby BA, Van Steen K, Lasky-Su J, Tantisira K, Kaplan F, Weiss ST, Raby BA, Van Steen K, Lasky-Su J, Tantisira K, Kaplan F, Weiss ST., Free PMC Articles: PMC2724419, PMC2724419 | 01/21/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma.
Raby BA, Van Steen K, Lasky-Su J, Tantisira K, Kaplan F, Weiss ST, Raby BA, Van Steen K, Lasky-Su J, Tantisira K, Kaplan F, Weiss ST., Free PMC Articles: PMC2724419, PMC2724419 | 08/12/2009 |
| Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers | Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers.
Walker P, Doenecke D, Kahle J., Free PMC Article | 01/21/2010 |
| Imp13 functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation. | Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin.
Liang J, Ke G, You W, Peng Z, Lan J, Kalesse M, Tartakoff AM, Kaplan F, Tao T. | 01/21/2010 |