| LPIN2 -related Majeed syndrome: report of two Indian patients with novel variants in LPIN2 and review of literature. | LPIN2 -related Majeed syndrome: report of two Indian patients with novel variants in LPIN2 and review of literature.
Badiger VA, Balan S, Madan S, Gogineni KS, Shah H, Narayanan DL. | 12/28/2023 |
| Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon. | Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon.
de Pablo N, Meana C, Martínez-García J, Martínez-Vicente P, Albert M, Guerra S, Angulo A, Balsinde J, Balboa MA., Free PMC Article | 12/16/2023 |
| Identification of lipidomic profiles associated with drug-resistant prostate cancer cells. | Identification of lipidomic profiles associated with drug-resistant prostate cancer cells.
Ingram LM, Finnerty MC, Mansoura M, Chou CW, Cummings BS., Free PMC Article | 11/6/2021 |
| Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis. | Novel Majeed Syndrome-Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis.
Bhuyan F, de Jesus AA, Mitchell J, Leikina E, VanTries R, Herzog R, Onel KB, Oler A, Montealegre Sanchez GA, Johnson KA, Bichell L, Marrero B, De Castro LF, Huang Y, Calvo KR, Collins MT, Ganesan S, Chernomordik LV, Ferguson PJ, Goldbach-Mansky R., Free PMC Article | 08/14/2021 |
| Data reveal that LPIN2 silencing interferes with HCV virion secretion at late stages of the infection, without significantly LPIN2-deficient cells display alterations in mitochondrial and Golgi apparatus morphology, suggesting that LPIN2 contributes to the maintenance of the overall organelle architecture. These data suggest a broader function of LPIN2 for replication of HCV and other RNA viruses. | Differential Roles of Lipin1 and Lipin2 in the Hepatitis C Virus Replication Cycle.
Castro V, Calvo G, Ávila-Pérez G, Dreux M, Gastaminza P., Free PMC Article | 07/25/2020 |
| we proposed that four newly identified peripheral blood mononuclear cells-derived genes( DHRS3, TTC38, SAP30BP and LPIN2 )could be integrated with previously reported rheumatoid arthritis (RA)-associated genes to monitor and/or diagnose RA. | New genes associated with rheumatoid arthritis identified by gene expression profiling.
Wang H, Guo J, Jiang J, Wu W, Chang X, Zhou H, Li Z, Zhao J. | 12/16/2017 |
| Structural variants unique to the malignant cell line inactivated: LPIN2, a phosphatidic acid phosphatase and a co-factor of PGC1a that is important for lipid metabolism and for suppressing autoinflammation. | Chromosomal structural variations during progression of a prostate epithelial cell line to a malignant metastatic state inactivate the NF2, NIPSNAP1, UGT2B17, and LPIN2 genes.
Malhotra A, Shibata Y, Hall IM, Dutta A., Free PMC Article | 05/16/2015 |
| We describe two brothers with Majeed syndrome, homozygous novel 2-base pair deletion in LPIN2 (c.1312_1313delCT; p.Leu438fs+16X) | Efficacy of anti-IL-1 treatment in Majeed syndrome.
Herlin T, Fiirgaard B, Bjerre M, Kerndrup G, Hasle H, Bing X, Ferguson PJ., Free PMC Article | 04/20/2013 |
| LPIN1-related myolysis constitutes a major cause of early-onset rhabdomyolysis and occasionally in adults. Heterozygous LPIN1 mutations may cause mild muscular symptoms. No major defects of LPIN2 or LPIN3 genes were associated with muscle manifestations. | Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.
Michot C, Hubert L, Romero NB, Gouda A, Mamoune A, Mathew S, Kirk E, Viollet L, Rahman S, Bekri S, Peters H, McGill J, Glamuzina E, Farrar M, von der Hagen M, Alexander IE, Kirmse B, Barth M, Laforet P, Benlian P, Munnich A, JeanPierre M, Elpeleg O, Pines O, Delahodde A, de Keyzer Y, de Lonlay P. | 04/6/2013 |
| role of lipin-2 in the proinflammatory action of saturated fatty acids in murine and human macrophages | Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages.
Valdearcos M, Esquinas E, Meana C, Peña L, Gil-de-Gómez L, Balsinde J, Balboa MA., Free PMC Article | 09/22/2012 |
| Data revealed that lipin 1 formed stable homo-oligomers with itself and hetero-oligomers with lipin 2/3. | Lipin proteins form homo- and hetero-oligomers.
Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE., Free PMC Article | 12/11/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes.
Hurtado-Nedelec M, Chollet-Martin S, Chapeton D, Hugot JP, Hayem G, Gérard B. | 01/20/2010 |
| A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. | A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.
Donkor J, Zhang P, Wong S, O'Loughlin L, Dewald J, Kok BP, Brindley DN, Reue K., Free PMC Article | 01/21/2010 |
| lipin 2 plays an important role as a hepatic PAP-1 enzyme. | Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.
Gropler MC, Harris TE, Hall AM, Wolins NE, Gross RW, Han X, Chen Z, Finck BN., Free PMC Article | 01/21/2010 |
| distinct and non-redundant functions of lipin 1 and 2 regulate lipid production during the cell cycle and adipocyte differentiation | Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition.
Aulchenko YS, Pullen J, Kloosterman WP, Yazdanpanah M, Hofman A, Vaessen N, Snijders PJ, Zubakov D, Mackay I, Olavesen M, Sidhu B, Smith VE, Carey A, Berezikov E, Uitterlinden AG, Plasterk RH, Oostra BA, van Duijn CM, Aulchenko YS, Pullen J, Kloosterman WP, Yazdanpanah M, Hofman A, Vaessen N, Snijders PJ, Zubakov D, Mackay I, Olavesen M, Sidhu B, Smith VE, Carey A, Berezikov E, Uitterlinden AG, Plasterk RH, Oostra BA, van Duijn CM. | 03/13/2008 |
| A single nucleotide polymorphism of the LPIN2 gene is associated with type 2 diabetes and fat distribution. | LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition.
Aulchenko YS, Pullen J, Kloosterman WP, Yazdanpanah M, Hofman A, Vaessen N, Snijders PJ, Zubakov D, Mackay I, Olavesen M, Sidhu B, Smith VE, Carey A, Berezikov E, Uitterlinden AG, Plasterk RH, Oostra BA, van Duijn CM, Aulchenko YS, Pullen J, Kloosterman WP, Yazdanpanah M, Hofman A, Vaessen N, Snijders PJ, Zubakov D, Mackay I, Olavesen M, Sidhu B, Smith VE, Carey A, Berezikov E, Uitterlinden AG, Plasterk RH, Oostra BA, van Duijn CM. | 01/21/2010 |
| LPIN2 gene was excluded as a candidate for myopia 2 (MYP2), but the SNPs detected in this study will aid in future mapping and association studies involving this gene. | Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia.
Zhou J, Young TL. | 01/21/2010 |
| We conclude that homozygous mutations in LPIN2 result in Majeed syndrome. Understanding the aberrant immune response in this condition will shed light on the aetiology of other inflammatory disorders of multifactorial aetiology | Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome).
Ferguson PJ, Chen S, Tayeh MK, Ochoa L, Leal SM, Pelet A, Munnich A, Lyonnet S, Majeed HA, El-Shanti H., Free PMC Article | 01/21/2010 |