| Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis of Endothelial Cells in a Microtubule-Dependent Manner. | Centrosomal Protein CEP135 Regulates the Migration and Angiogenesis of Endothelial Cells in a Microtubule-Dependent Manner.
Wang K, Wang X, Zhao F, Zhao Q, Kong S, Ma P, Wu G, Wang W, Zhang X. | 01/4/2024 |
| Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells. | Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells.
Chu Z, Gruss OJ., Free PMC Article | 04/30/2022 |
| Mutation in CEP135 causing primary microcephaly and subcortical heterotopia. | Mutation in CEP135 causing primary microcephaly and subcortical heterotopia.
Bamborschke D, Daimagüler HS, Hahn A, Hussain MS, Nürnberg P, Cirak S. | 06/5/2021 |
| Dysregulation of CEP135 isoforms promotes centriole overduplication and contributes to chromosome segregation errors in breast cancer cells. | CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells.
Ganapathi Sankaran D, Stemm-Wolf AJ, Pearson CG., Free PMC Article | 09/14/2019 |
| The analysis of the distribution of genotypes in CEP135 rs4865047 and NPY2R rs1902491 detected significant differences only in the single nucleotide polymorphism rs4865047 genotype between the case and control group in comparison to the reference group. The co-dominant model showed that CEP135 rs4865047 was significantly associated with patients with rapidly progressive proliferative diabetic retinopathy | The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.
Derkac I, Januleviciene I, Sepetiene R, Valiauga R, Velickiene D., Free PMC Article | 03/9/2019 |
| CEP135 segment 96-108 is a major microtubule-binding site. | The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.
Kraatz S, Guichard P, Obbineni JM, Olieric N, Hatzopoulos GN, Hilbert M, Sen I, Missimer J, Gönczy P, Steinmetz MO. | 02/3/2018 |
| identified the second mutation in CEP135, confirming the role during embryonic brain development and in the pathophysiology of human primary microcephaly | A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family.
Farooq M, Fatima A, Mang Y, Hansen L, Kjaer KW, Baig SM, Larsen LA, Tommerup N. | 12/31/2016 |
| Authors suggest that the decrease in CEP135(mini) from centrosomes promotes centriole assembly. The repression of centriole duplication by a splice isoform of a protein that normally promotes it serves as a novel mechanism to limit centriole duplication. | A Short CEP135 Splice Isoform Controls Centriole Duplication.
Dahl KD, Sankaran DG, Bayless BA, Pinter ME, Galati DF, Heasley LR, Giddings TH Jr, Pearson CG., Free PMC Article | 08/27/2016 |
| These findings support a model in which PKC-mediated phosphorylation of CEP4 at Ser(18) and Ser(80) causes its dissociation from Cdc42, thereby increasing its affinity for TEM4 and producing Rac activation, filopodium formation, and cell motility | Phosphorylation of Cdc42 effector protein-4 (CEP4) by protein kinase C promotes motility of human breast cells.
Zhao X, Rotenberg SA., Free PMC Article | 02/21/2015 |
| Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. | Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.
Lin YC, Chang CW, Hsu WB, Tang CJ, Lin YN, Chou EJ, Wu CT, Tang TK., Free PMC Article | 06/22/2013 |
| A truncating mutation of CEP135 caused autosomal-recessive primary microcephaly in a Pakistani family. | A truncating mutation of CEP135 causes primary microcephaly and disturbed centrosomal function.
Hussain MS, Baig SM, Neumann S, Nürnberg G, Farooq M, Ahmad I, Alef T, Hennies HC, Technau M, Altmüller J, Frommolt P, Thiele H, Noegel AA, Nürnberg P., Free PMC Article | 06/30/2012 |
| CEP135 acts as a platform protein for C-NAP1 at the centriole. | A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization.
Kim K, Lee S, Chang J, Rhee K. | 01/21/2010 |