| Exploring the Roles of Key Mediators IKBKE and HSPA1A in Alzheimer's Disease and Hepatocellular Carcinoma through Bioinformatics Analysis. | Exploring the Roles of Key Mediators IKBKE and HSPA1A in Alzheimer's Disease and Hepatocellular Carcinoma through Bioinformatics Analysis.
Wang Y, Yang Y, Liang C, Zhang H., Free PMC Article | 08/9/2024 |
| IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma. | IKBKE regulates angiogenesis by modulating VEGF expression and secretion in glioblastoma.
Zhu L, Guo G, Jin Y, Hu A, Liu Y. | 09/7/2023 |
| Dengue Virus 2 NS2B Targets MAVS and IKKepsilon to Evade the Antiviral Innate Immune Response. | Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune Response.
Nie Y, Deng D, Mou L, Long Q, Chen J, Wu J., Free PMC Article | 06/2/2023 |
| Promotion of Knee Cartilage Degradation by IkappaB Kinase epsilon in the Pathogenesis of Osteoarthritis in Human and Murine Models. | Promotion of Knee Cartilage Degradation by IκB Kinase ε in the Pathogenesis of Osteoarthritis in Human and Murine Models.
Uchida T, Akasaki Y, Sueishi T, Kurakazu I, Toya M, Kuwahara M, Hirose R, Hyodo Y, Tsushima H, Lotz MK, Nakashima Y. | 06/1/2023 |
| Increased IKK protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency. | Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.
Wegner J, Hunkler C, Ciupka K, Hartmann G, Schlee M., Free PMC Article | 03/27/2023 |
| IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus. | IKBKE and BANK1 Polymorphisms and Clinical Characteristics in Chinese Women with Systemic Lupus Erythematosus.
Zhang P, Zhai J, Wang K, Wu Y. | 10/8/2022 |
| IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis. | IKBKE phosphorylates and stabilizes Snail to promote breast cancer invasion and metastasis.
Xie W, Jiang Q, Wu X, Wang L, Gao B, Sun Z, Zhang X, Bu L, Lin Y, Huang Q, Li J, Guo J., Free PMC Article | 08/6/2022 |
| Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation. | Silencing IKBKE inhibits the migration and invasion of glioblastoma by promoting Snail1 degradation.
Liu Y, Guo G, Lu Y, Chen X, Zhu L, Zhao L, Li C, Zhang Z, Jin X, Dong J, Yang X, Huang Q. | 04/30/2022 |
| Akt phosphorylation regulated by IKKepsilon in response to low shear stress leads to endothelial inflammation via activating IRF3. | Akt phosphorylation regulated by IKKε in response to low shear stress leads to endothelial inflammation via activating IRF3.
Zhu L, Yang H, Chao Y, Gu Y, Zhang J, Wang F, Yu W, Ye P, Chu P, Kong X, Chen S. | 01/22/2022 |
| TBK1 and IKKepsilon act like an OFF switch to limit NLRP3 inflammasome pathway activation. | TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.
Fischer FA, Mies LFM, Nizami S, Pantazi E, Danielli S, Demarco B, Ohlmeyer M, Lee MSJ, Coban C, Kagan JC, Di Daniel E, Bezbradica JS., Free PMC Article | 12/18/2021 |
| Peroxiredoxin 1 Interacts with TBK1/IKKepsilon and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity. | Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.
Lv L, Bai J, Gao Y, Jin L, Wang X, Cao M, Liu X, Jiang P., Free PMC Article | 10/16/2021 |
| miR-133a-3p attenuates cardiomyocyte hypertrophy through inhibiting pyroptosis activation by targeting IKKepsilon. | miR-133a-3p attenuates cardiomyocyte hypertrophy through inhibiting pyroptosis activation by targeting IKKε.
Zhu YF, Wang R, Chen W, Cao YD, Li LP, Chen X. | 10/9/2021 |
| IKKepsilon isoform switching governs the immune response against EV71 infection. | IKKε isoform switching governs the immune response against EV71 infection.
Chang YL, Liao YW, Chen MH, Chang SY, Huang YT, Ho BC, Yu SL., Free PMC Article | 08/14/2021 |
| The decreased expression of IKBKE in systemic lupus erythematosus. | The decreased expression of IKBKE in systemic lupus erythematosus.
Zhu T, Hong J, Shuai Z, Xu S, Qian D, Hong X, Liu Y, Chen M, Meng Z, Zheng L, Zheng D, Zhang X, Liu L., Free PMC Article | 06/12/2021 |
| IKKepsilon and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKepsilon/TBK1 inhibitor to repress NF-kappaB and IL-10 signalling. | IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.
Carr M, Mamand S, Chapman KL, Perrior T, Wagner SD., Free PMC Article | 05/8/2021 |
| IKBKE enhances TMZ-chemoresistance through upregulation of MGMT expression in glioblastoma. | IKBKE enhances TMZ-chemoresistance through upregulation of MGMT expression in glioblastoma.
Guo G, Sun Y, Hong R, Xiong J, Lu Y, Liu Y, Lu J, Zhang Z, Guo C, Nan Y, Huang Q. | 04/3/2021 |
| The breast cancer oncogene IKKepsilon coordinates mitochondrial function and serine metabolism. | The breast cancer oncogene IKKε coordinates mitochondrial function and serine metabolism.
Xu R, Jones W, Wilcz-Villega E, Costa AS, Rajeeve V, Bentham RB, Bryson K, Nagano A, Yaman B, Olendo Barasa S, Wang Y, Chelala C, Cutillas P, Szabadkai G, Frezza C, Bianchi K., Free PMC Article | 03/20/2021 |
| Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon. | Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon.
Lundberg R, Melén K, Westenius V, Jiang M, Österlund P, Khan H, Vapalahti O, Julkunen I, Kakkola L., Free PMC Article | 09/19/2020 |
| IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway. | IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway.
Bainbridge A, Walker S, Smith J, Patterson K, Dutt A, Ng YM, Thomas HD, Wilson L, McCullough B, Jones D, Maan A, Banks P, McCracken SR, Gaughan L, Robson CN, Coffey K., Free PMC Article | 08/22/2020 |
| Results demonstrate that PDCoV NS7a inhibits IFN-beta production by disrupting the association of IKKepsilon with both TRAF3 and IRF3, revealing a new mechanism utilized by a PDCoV accessory protein to evade the host antiviral innate immune response. | Porcine Deltacoronavirus Accessory Protein NS7a Antagonizes IFN-β Production by Competing With TRAF3 and IRF3 for Binding to IKKε.
Fang P, Fang L, Xia S, Ren J, Zhang J, Bai D, Zhou Y, Peng G, Zhao S, Xiao S., Free PMC Article | 07/25/2020 |
| E3 ubiquitin ligase ankyrin repeat and SOCS box-containing 8(ASB8) interacted with TBK1/IKKi and phosphorylation modification of ASB8 at site of Ser17 to further strengthen its ubiquitination activity were verified. Phosphorylated ASB8 accelerates K48-linked ubiquitination and degradation of TBK1/IKKi, which further reduces phosphorylation level of IRF3 and inhibits production of IFN-beta. | E3 ubiquitin ligase ASB8 negatively regulates interferon via regulating TBK1/IKKi homeostasis.
Guo Y, Li R, Tan Z, Shi J, Fu Y, Song Y, Zhu M, Zhang L, Huang J. | 07/18/2020 |
| Rab7, a recently identified substrate of PTEN phosphatase activity, is also a substrate of the innate immune signaling kinases TANK-binding kinase 1 (TBK1)/IkappaB kinase epsilon (IKKepsilon) on the same serine-72 site. TBK1/IKKepsilon mediated phosphorylation of this site as a key regulator of Rab7 mislocalization, which sustains levels of the upstream TBK1 adaptor STING, and thus promotes hyperactive innate immune si... | Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.
Ritter JL, Zhu Z, Thai TC, Mahadevan NR, Mertins P, Knelson EH, Piel BP, Han S, Jaffe JD, Carr SA, Barbie DA, Barbie TU., Free PMC Article | 06/20/2020 |
| high levels of IKKepsilon might induce intractable inflammation via CXCL10. | CXCL10 production induced by high levels of IKKε in nasal airway epithelial cells in the setting of chronic inflammation.
Nam YR, Lee KJ, Lee H, Joo CH. | 06/20/2020 |
| IKBKE-dependent autophagy is necessary for breast cancer cell proliferation. | Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy.
Leonardi M, Perna E, Tronnolone S, Colecchia D, Chiariello M., Free PMC Article | 03/7/2020 |
| Collectively, these data reveal an evolutionarily conserved and critical role of TBK1/IKKepsilon suppression in expanding functional beta-cell mass. | Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.
Xu J, Jia YF, Tapadar S, Weaver JD, Raji IO, Pithadia DJ, Javeed N, García AJ, Choi DS, Matveyenko AV, Oyelere AK, Shin CH., Free PMC Article | 11/23/2019 |