| Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function. | Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function.
Carter EP, Yoneten KK, Gavara N, Tyler EJ, Gauthier V, Murray ER, Ten Dijke P, Cameron AJ, Pearce O, Grose RP., Free PMC Article | 12/16/2023 |
| Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci. | Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.
Earley EJ, Kelly S, Fang F, Alencar CS, Rodrigues DOW, Soares Cruz DT, Flanagan JM, Ware RE, Zhang X, Gordeuk V, Gladwin M, Zhang Y, Nouraie M, Nekhai S, Sabino E, Custer B, Dinardo C, Page GP, International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III) and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium., Free PMC Article | 04/7/2023 |
| Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft palate dysplasia. | Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft palate dysplasia.
Zhang Y, Li J, Ji Y, Cheng Y, Fu X. | 12/24/2022 |
| ADAMTS12, a new candidate gene for pediatric stroke. | ADAMTS12, a new candidate gene for pediatric stroke.
Witten A, Rühle F, de Witt M, Barysenka A, Stach M, Junker R, Nowak-Göttl U, Stoll M., Free PMC Article | 10/24/2020 |
| Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics. | Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics.
Ruso-Julve F, Pombero A, Pilar-Cuéllar F, García-Díaz N, Garcia-Lopez R, Juncal-Ruiz M, Castro E, Díaz Á, Vazquez-Bourgón J, García-Blanco A, Garro-Martinez E, Pisonero H, Estirado A, Ayesa-Arriola R, López-Giménez J, Mayor F Jr, Valdizán E, Meana J, Gonzalez-Maeso J, Martínez S, Vaqué JP, Crespo-Facorro B., Free PMC Article | 09/26/2020 |
| Our research revealed that partial microduplication of ADAMTS2 (chr5:178728830-178997692) might be benign and not correlate with disorders. And there might exist phenotypic diversities of 5q35.3 duplications. | Prenatal diagnosis of a 5q35.3 microduplication involving part of the ADAMTS2 locus: a likely benign variant without apparent phenotypic abnormality: Case series.
Yue F, Yu Y, Xi Q, Zhang H, Jiang Y, Li S, Liu R, Wang R., Free PMC Article | 12/28/2019 |
| ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of the uterosacral ligament play essential roles in the etiopathogenesis of pelvic organ prolapse among postmenopausal women without stress urinary incontinence. | The role of ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of uterosacral and cardinal ligaments in the etiopathogenesis of pelvic organ prolapse among women without stress urinary incontinence.
Tola EN, Koroglu N, Yıldırım GY, Koca HB. | 04/6/2019 |
| We identified three novel homozygous loss-of-function mutations (c.2927_2928delCT, p.(Pro976Argfs*42); c.669_670dupG, p.(Pro224Argfs*24); and c.2751-2A>T) and one compound heterozygous mutation (c.2T>C, p.? and c.884_887delTGAA, p.(Met295Thrfs26*)) in ADAMTS2 in five patients from four unrelated families | Expanding the clinical and mutational spectrum of the Ehlers-Danlos syndrome, dermatosparaxis type.
Van Damme T, Colige A, Syx D, Giunta C, Lindert U, Rohrbach M, Aryani O, Alanay Y, Simsek-Kiper PÖ, Kroes HY, Devriendt K, Thiry M, Symoens S, De Paepe A, Malfait F. | 12/16/2017 |
| Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review] | The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.
Bekhouche M, Colige A. | 03/26/2016 |
| IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression. | Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells.
Alper M, Aydemir AT, Köçkar F. | 12/19/2015 |
| ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD | Gene expression profiling of craniofacial fibrous dysplasia reveals ADAMTS2 overexpression as a potential marker.
Zhou SH, Yang WJ, Liu SW, Li J, Zhang CY, Zhu Y, Zhang CP., Free PMC Article | 10/31/2015 |
| Pathway inhibition studies revealed that ADAMTS-2 upregulation by IL-6 was mediated by JNK pathway. | IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway.
Alper M, Kockar F. | 02/14/2015 |
| ADAMTS-2, -3, and -13 expression, but not that of ADAMTS-14, are increased in plaques causing AMI compared those associated with stable angina. | Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.
Lee CW, Hwang I, Park CS, Lee H, Park DW, Kang SJ, Lee SW, Kim YH, Park SW, Park SJ. | 08/25/2012 |
| Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis. | ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity.
Dubail J, Kesteloot F, Deroanne C, Motte P, Lambert V, Rakic JM, Lapière C, Nusgens B, Colige A., Free PMC Article | 01/1/2011 |
| Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein. | Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V.
Colige A, Ruggiero F, Vandenberghe I, Dubail J, Kesteloot F, Van Beeumen J, Beschin A, Brys L, Lapière CM, Nusgens B. | 07/22/2010 |
| Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function | Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene.
Colige A, Nuytinck L, Hausser I, van Essen AJ, Thiry M, Herens C, Adès LC, Malfait F, Paepe AD, Franck P, Wolff G, Oosterwijk JC, Smitt JH, Lapière CM, Nusgens BV. | 01/21/2010 |
| when conditioned media of TSP2-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 is a potential inhibitor of angiogenesis | Human thrombospondin 2 inhibits proliferation of microvascular endothelial cells.
Tomii Y, Kamochi J, Yamazaki H, Sawa N, Tokunaga T, Ohnishi Y, Kijima H, Ueyama Y, Tamaoki N, Nakamura M. | 01/21/2010 |