| Knockdown of NRAGE Impairs Homologous Recombination Repair and Sensitizes Hepatoblastoma Cells to Ionizing Radiation. | Knockdown of NRAGE Impairs Homologous Recombination Repair and Sensitizes Hepatoblastoma Cells to Ionizing Radiation.
Liu L, Cui Z, Zhang J, Wang J, Gu S, Ma J, Chen H, Hang L, Yang J, Shi Y. | 10/24/2020 |
| NRAGE is significantly upregulated in patients with Hepatocellular Carcinoma. It could possibly be a novel diagnostic biomarker for HCC early detection. | NRAGE is a potential diagnostic biomarker of hepatocellular carcinoma.
Zou W, Cui J, Ren Z, Leng Y., Free PMC Article | 01/12/2019 |
| Our results indicate that NRAGE subcellular localization is related to radiation resistance of esophageal carcinoma cell and EMT may be involved in NRAGE subcellular location. | The role of NRAGE subcellular location and epithelial-mesenchymal transition on radiation resistance of esophageal carcinoma cell.
Chang X, Xue X, Zhang Y, Zhang G, Zhou H, Yang Y, Ran Y, Xiao Z, Ge X, Liu H. | 09/1/2018 |
| NRAGE upregulation was correlated with advanced TNM stage, local invasion, and poor survival. Importantly, NRAGE could serve as an independent prognostic factor in patients with gastric cancer. | NRAGE confers poor prognosis and promotes proliferation, invasion, and chemoresistance in gastric cancer.
Jiang X, Jiang X, Yang Z. | 06/16/2018 |
| The nuclear localized NRAGE interacts with RNF8 and BARD1 to mediate the resistance of esophageal carcinomas cells against DNA-damaging agents. | NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8-BARD1 to promote cell survival in squamous esophageal tumorigenesis.
Yang Q, Pan Q, Li C, Xu Y, Wen C, Sun F., Free PMC Article | 01/13/2018 |
| these results demonstrate the effective anti-autophagic of NRAGE in non-small-cell lung cancer cells through AMPK/Ulk1/Atg13 autophagy signaling pathways. Therefore, NRAGE could be used as a potential therapeutic target for lung cancer. | Silencing of NRAGE induces autophagy via AMPK/Ulk1/Atg13 signaling pathway in NSCLC cells.
Zhou Y, Huang N, Wu J, Zhen N, Li N, Li Y, Li YX. | 07/15/2017 |
| MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AhR, HIF1alpha and ARNT. This interaction is mediated by PAS repeat regions which also form the interface for bHLH PAS dimerisation, and accordingly MAGED1 is not found in complex with bHLH PAS dimers. | MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.
Sullivan AE, Peet DJ, Whitelaw ML. | 07/1/2017 |
| our surprise, NRAGE induces nuclear localization of beta-catenin and increases its DNA binding ability. Further studies reveal that NRAGE leads to the modification of beta-catenin/Arm with O-linked beta-N-acetylglucosamine (O-GlcNAc), and failure of the association between beta-catenin/Arm and pygopus(pygo) protein, which is required for transcriptional activation of Wnt target genes. Therefore, our findings suggest a ... | NRAGE induces β-catenin/Arm O-GlcNAcylation and negatively regulates Wnt signaling.
Chen Y, Jin L, Xue B, Jin D, Sun F, Wen C. | 06/24/2017 |
| Loss of GSPT2 and/or MAGED1 function may contribute to the intellectual disability. | Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability.
Grau C, Starkovich M, Azamian MS, Xia F, Cheung SW, Evans P, Henderson A, Lalani SR, Scott DA., Free PMC Article | 04/29/2017 |
| The ectopic subcellular localization of NRAGE mediated nuclear translocation of beta-catenin. | Identification of novel NRAGE involved in the radioresistance of esophageal cancer cells.
Zhou H, Zhang G, Xue X, Yang Y, Yang Y, Chang X, Ge X, Xiao Z, Guo H, Wang Y. | 02/4/2017 |
| High NRAGE expression is associated with esophageal carcinomas. | NRAGE promotes cell proliferation by stabilizing PCNA in a ubiquitin-proteasome pathway in esophageal carcinomas.
Yang Q, Ou C, Liu M, Xiao W, Wen C, Sun F. | 09/27/2014 |
| MAGE-D1 plays important roles in the central nervous system in both developmental and adult stages. | The roles of MAGE-D1 in the neuronal functions and pathology of the central nervous system.
Mouri A, Noda Y, Watanabe K, Nabeshima T. | 08/10/2013 |
| Univariate and multivariate analyses indicated that MAGED1 expression was an independent prognostic factor in colorectal carcinoma | Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma.
Zeng ZL, Wu WJ, Yang J, Tang ZJ, Chen DL, Qiu MZ, Luo HY, Wang ZQ, Jin Y, Wang DS, Xu RH., Free PMC Article | 04/6/2013 |
| NRAGE may participate in the formation of radioresistance of TE13R120 cells by changing its subcellular localization, but its relationship with cell apoptosis has not been confirmed. | Relationship between NRAGE and the radioresistance of esophageal carcinoma cell line TE13R120.
Xue XY, Liu ZH, Jing FM, Li YG, Liu HZ, Gao XS. | 02/11/2012 |
| we establish the roles for Dlxin-1, one as an anti-tumorigenic and anti-invasive protein in high-grade gliomas and the other as an inducer of differentiation of glioma stem cells. | Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells.
Reddy EM, Chettiar ST, Kaur N, Ganeshkumar R, Shepal V, Shanbhag NC, Shiras A. | 06/18/2011 |
| Data report that NRAGE, via the same XIAP-Tak1-Tab1 complex, is required for the phosphorylation of IKK -alpha/beta and subsequent transcriptional activation of the p65 subunit of NF-kappaB. | A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway.
Matluk N, Rochira JA, Karaczyn A, Adams T, Verdi JM., Free PMC Article | 05/10/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| Enhanced expression of MAGE-D1 by gene transfer could reverse the malignant phenotypes of breast cancer cells. | MAGE-D1 inhibits proliferation, migration and invasion of human breast cancer cells.
Du Q, Zhang Y, Tian XX, Li Y, Fang WG. | 01/21/2010 |
| Data show that hNRAGE gene can inhibit the growth of 293 cells. | [Construction of recombinant adenovirus vector of hNRAGE gene and its effect on cell cycle of 293 cells].
Zhou LH, Xue B, Guo SY, Shi YH, Wen CJ, Li CJ. | 01/21/2010 |
| These findings provide new insight into the ability of MAGE-D1 to suppress the motility and adhesion response of tumor cells by interfering with actin cytoskeleton reorganization and hypoxia inducible factor 1-dependent gene expression. | Melanoma-associated antigen family protein-D1 regulation of tumor cell migration, adhesion to endothelium, and actin structures reorganization in response to hypoxic stress.
Shen WG, Xue QY, Wu YD, Hu BS, Zhu J, Zhang Y, Su Q. | 01/21/2010 |
| MAGE-D1 might be a novel inhibitor of angiogenesis in vitro and in vivo. | Inhibition of adenovirus-mediated human MAGE-D1 on angiogenesis in vitro and in vivo.
Shen WG, Xue QY, Zhu J, Hu BS, Zhang Y, Wu YD, Su Q. | 01/21/2010 |
| A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1. | A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K. | 01/21/2010 |
| studies indicate for the first time that NRAGE could suppress metastasis of melanoma and pancreatic cancer probably through downregulation of MMP-2 | NRAGE suppresses metastasis of melanoma and pancreatic cancer in vitro and in vivo.
Chu CS, Xue B, Tu C, Feng ZH, Shi YH, Miao Y, Wen CJ. | 01/21/2010 |
| Che-1 interacts with NRAGE and NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation. | NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death.
Di Certo MG, Corbi N, Bruno T, Iezzi S, De Nicola F, Desantis A, Ciotti MT, Mattei E, Floridi A, Fanciulli M, Passananti C. | 01/21/2010 |
| MAGE-D1 protein expression was reduced in 6 of 16 breast carcinoma cell lines as compared with untransformed immortal mammary epithelial cell lines; suppression of MAGE-D1 expression may be involved in the tumorigenesis of some sporadic breast cancers. | BRCA2 suppresses cell proliferation via stabilizing MAGE-D1.
Tian XX, Rai D, Li J, Zou C, Bai Y, Wazer D, Band V, Gao Q., Free PMC Article | 01/21/2010 |