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    NAPSA napsin A aspartic peptidase [ Homo sapiens (human) ]

    Gene ID: 9476, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    P504S/alpha-methylacyl-CoA racemase, HNF1beta and napsin A in morular metaplasia and clear cell carcinoma of the endometrium: An immunohistochemical analysis.

    P504S/alpha-methylacyl-CoA racemase, HNF1β and napsin A in morular metaplasia and clear cell carcinoma of the endometrium: An immunohistochemical analysis.
    Arciuolo D, Travaglino A, Raffone A, Santoro A, Inzani F, Piermattei A, Bui L, Scaglione G, D'Alessandris N, Valente M, Fulgione C, Guida M, Mollo A, Insabato L, Zannoni GF.

    08/13/2022
    A study on the immunohistochemical expression of napsin A in oral squamous cell carcinomas, intraepithelial neoplasia, and normal oral mucosa.

    A study on the immunohistochemical expression of napsin A in oral squamous cell carcinomas, intraepithelial neoplasia, and normal oral mucosa.
    Gaydarov N, Martinelli-Kläy CP, Lombardi T.

    03/5/2022
    Napsin-A and AMACR are Superior to HNF-1beta in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract.

    Napsin-A and AMACR are Superior to HNF-1β in Distinguishing Between Mesonephric Carcinomas and Clear Cell Carcinomas of the Gynecologic Tract.
    Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L., Free PMC Article

    08/7/2021
    Role of Napsin A and Survivin Immunohistochemical Expression in Bronchogenic Adenocarcinoma.

    Role of Napsin A and Survivin Immunohistochemical Expression in Bronchogenic Adenocarcinoma.
    Mohammed Salama ME., Free PMC Article

    08/7/2021
    Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors.

    Napsin A is a highly sensitive marker for nephrogenic adenoma: an immunohistochemical study with a specificity test in genitourinary tumors.
    Sharifai N, Abro B, Chen JF, Zhao M, He H, Cao D.

    02/20/2021
    Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival.

    Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival.
    Pocha K, Mock A, Rapp C, Dettling S, Warta R, Geisenberger C, Jungk C, Martins LR, Grabe N, Reuss D, Debus J, von Deimling A, Abdollahi A, Unterberg A, Herold-Mende CC.

    02/6/2021
    Immunohistochemical expression of Napsin A in normal human fetal lungs at different gestational ages and in acquired and congenital pathological pulmonary conditions.

    Immunohistochemical expression of Napsin A in normal human fetal lungs at different gestational ages and in acquired and congenital pathological pulmonary conditions.
    Giordano G, Campanini N, Varotti E.

    10/10/2020
    Data indicate that lung napsin A aspartic peptidase (napsin A) in many mammals is a heterogeneous enzyme.

    Pepstatin pull-down at high pH is a powerful tool for detection and analysis of napsin A.
    Maurer A, Kalbacher H.

    07/4/2020
    Napsin A is of value in resolving diagnostic confusion between gastric-type adenocarcinoma (GAS) and clear cell carcinoma (CCC), whereas HNF1beta lacks specificity and its use in this setting is discouraged.

    Expression of Markers of Müllerian Clear Cell Carcinoma in Primary Cervical and Vaginal Gastric-type Adenocarcinomas.
    Talia KL, Wong RW, McCluggage WG.

    08/3/2019
    Raspberry bodies and hyaline globules with positive napsin A immunoexpression are useful features in diagnosing clear cell carcinoma.

    Raspberry bodies and hyaline globules with positive napsin A immunoexpression are useful features in diagnosing clear cell carcinoma of the female genital tract in cytology samples.
    Rekhi B, Deodhar K, Gulia S, Bajpai J.

    07/27/2019
    These data indicated that napsin A expression may inhibit TGFbetalinduced EMT and was negatively associated with EMTmediated erlotinib resistance, suggesting that napsin A expression may improve the sensitivity of lung cancer cells to EGFRTKI through the inhibition of EMT.

    Napsin A is negatively associated with EMT‑mediated EGFR‑TKI resistance in lung cancer cells.
    Zhou L, Lv X, Yang J, Zhu Y, Wang Z, Xu T.

    10/20/2018
    Although napsin A is infrequently expressed in endometrial carcinomas, positive results of napsin A immunostaining in endometrial neoplasms might support the diagnosis of clear cell carcinoma when the pathologic differential diagnosis includes other histologic subtypes

    Infrequent Immunohistochemical Expression of Napsin A in Endometrial Carcinomas.
    Al-Maghrabi JA, Butt NS, Anfinan N, Sait K, Sait H, Marzouki A, Khabaz MN.

    05/5/2018
    Immunohistochemical detection of thyroid transcription factor 1, Napsin A, and P40 fragment of TP63 can be used in the subclassification of non-small cell lung carcinomas.

    Utility of a novel triple marker (combination of thyroid transcription factor 1, Napsin A, and P40) in the subclassification of non-small cell lung carcinomas using fine-needle aspiration cases.
    Sharma R, Wang Y, Chen L, Gurda GT, Geddes S, Gabrielson E, Askin F, Li QK.

    08/19/2017
    it may be useful to combine NAPA and TTF-1 for increased sensitivity in lung cancer diagnostics. There is no substantial difference between monoclonal and polyclonal p40 and between different NAPA clones, whereas there is a difference between the TTF-1 clones 8G7G3/1 and SPT24

    Various Antibody Clones of Napsin A, Thyroid Transcription Factor 1, and p40 and Comparisons With Cytokeratin 5 and p63 in Histopathologic Diagnostics of Non-Small Cell Lung Carcinoma.
    Tran L, Mattsson JS, Nodin B, Jönsson P, Planck M, Jirström K, Botling J, Micke P, Brunnström H.

    08/5/2017
    To the best of our knowledge, expression of monoclonal Napsin A in lymphomas has never been reported. ALK-DLBCL should be considered in the differential diagnosis when evaluating a Napsin A-positive tumor of poorly differentiated morphology and of unknown primary

    Napsin A Expression in Anaplastic Lymphoma Kinase-positive Diffuse Large B-Cell Lymphoma: A Diagnostic Pitfall.
    Jain D, Mallick SR, Singh V, Singh G, Mathur SR, Sharma MC.

    06/3/2017
    It is important for pathologists to be aware that breast carcinomas with apocrine features can express napsin A.

    Aberrant Expression of Napsin A in Breast Carcinoma With Apocrine Features.
    Vitkovski T, Chaudhary S, Sison C, Nasim M, Esposito MJ, Bhuiya T.

    04/15/2017
    High Napsin A expression is associated with adenocarcinoma in non-small cell lung carcinoma.

    Napsin A/p40 antibody cocktail for subtyping non-small cell lung carcinoma on cytology and small biopsy specimens.
    Nishino M, Hoang MP, Della Pelle P, Morales-Oyarvide V, Huynh TG, Mark EJ, Mino-Kenudson M.

    02/25/2017
    Napsin-A, and Desmocollin-3 were sensitive and specific markers for the diagnosis of AC and SCC, respectively. Both markers allowed classification of 54/60 cases into either AC or SCC.

    The role of Napsin-A and Desmocollin-3 in classifying poorly differentiating non-small cell lung carcinoma.
    Ezzat Nel-S, Tahoun N.

    12/17/2016
    napsin A is aberrantly expressed in a subset of lymphomas

    Aberrant expression of napsin A in a subset of malignant lymphomas.
    Nam SJ, Kim S, Kim JE, Lim MS, Elenitoba-Johnson KS, Kim CW, Jeon YK.

    10/22/2016
    CK7, TTF-1 and napsin A are predominantly expressed in primary lung adenocarcinoma patients, with CDX-2 being inconsistently expressed.

    CDX-2 Expression in Primary Lung Adenocarcinoma.
    Cowan ML, Li QK, Illei PB.

    09/17/2016
    The immunocytochemical expressions of napsin A and p40 in imprint cytology seem to be of great utility for the accurate histological differentiation of lung cancers.

    Expressions of Thyroid Transcription Factor-1, Napsin A, p40, p63, CK5/6 and Desmocollin-3 in Non-Small Cell Lung Cancer, as Revealed by Imprint Cytology Using a Malinol-Based Cell-Transfer Technique.
    Kawai T, Tominaga S, Hiroi S, Kameda K, Ogata S, Nakashima H, Ozeki Y, Nakanishi K.

    07/16/2016
    Combining HNF-1beta and napsin A may distinguish clear cell carcinoma from high-grade serous carcinoma, endometrioid adenocarcinoma and metastatic Krukenberg tumors.

    Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma.
    Li Q, Zeng X, Cheng X, Zhang J, Ji J, Wang J, Xiong K, Qi Q, Huang W., Free PMC Article

    06/11/2016
    napsin A is another sensitive and specific marker for distinguishing ovarian clear cell tumors (especially adenocarcinomas) from other ovarian tumors

    Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
    Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S.

    04/2/2016
    Napsin A is expressed in a broad spectrum of renal neoplasms.

    Immunoexpression of napsin A in renal neoplasms.
    Zhu B, Rohan SM, Lin X., Free PMC Article

    02/6/2016
    Low expression levels of NAPSA is associated with lung adenocarcinoma.

    The expression of TTF-1 and Napsin A in early-stage lung adenocarcinoma correlates with the results of surgical treatment.
    Ma Y, Fan M, Dai L, Kang X, Liu Y, Sun Y, Yan W, Liang Z, Xiong H, Chen K.

    01/30/2016
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