| Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB. | Insights into the Direct Oxidative Repair of Etheno Lesions: MD and QM/MM Study on the Substrate Scope of ALKBH2 and AlkB.
Lenz SAP, Li D, Wetmore SD., Free PMC Article | 04/3/2021 |
| Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB. | Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB.
Baldwin MR, Admiraal SJ, O'Brien PJ., Free PMC Article | 12/26/2020 |
| SSB-AlkB interaction promotes faster repair of the methyl DNA adducts. | Escherichia coli single-stranded DNA binding protein SSB promotes AlkB-mediated DNA dealkylation repair.
Nigam R, Anindya R. | 02/17/2018 |
| AlkB has a wide variety of substrates, including monoalkyl and exocyclic bridged adducts. (Review) | The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM., Free PMC Article | 11/28/2015 |
| AlkB dioxygenase preferentially repairs protonated substrates: specificity against exocyclic adducts and molecular mechanism of action | AlkB dioxygenase preferentially repairs protonated substrates: specificity against exocyclic adducts and molecular mechanism of action.
Maciejewska AM, Poznanski J, Kaczmarska Z, Krowisz B, Nieminuszczy J, Polkowska-Nowakowska A, Grzesiuk E, Kusmierek JT., Free PMC Article | 03/2/2013 |
| The AlkB dioxygenase plays a major role in decreasing the level of AT-->TA mutations, thus in the repair of Etheno-DNA adducts in E.coli cells. | The role of AlkB protein in repair of 1,N⁶-ethenoadenine in Escherichia coli cells.
Maciejewska AM, Sokołowska B, Nowicki A, Kuśmierek JT. | 08/27/2011 |
| Cocrystal structures provide insight into the structural basis of this "k(cat)/K(m) compensation," which makes a significant contribution to promiscuous substrate recognition by AlkB. | Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB.
Yu B, Hunt JF., Free PMC Article | 01/21/2010 |
| N-terminus verified by Edman degradation on complete protein | Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA.
Kondo H, Nakabeppu Y, Kataoka H, Kuhara S, Kawabata S, Sekiguchi M. | 11/5/2007 |
| work provides direct evidence that AlkB suppresses both genotoxicity and mutagenesis by physiologically realistic low doses of 1-alkylpurine and 3-alkylpyrimidine DNA damage in vivo | Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli.
Delaney JC, Essigmann JM., Free PMC Article | 01/21/2010 |
| AlkB dioxygenase, PolV (UmuD'C), and AlkA have roles in preventing MMS-induced mutagenesis in Escherichia coli | AlkB dioxygenase in preventing MMS-induced mutagenesis in Escherichia coli: effect of Pol V and AlkA proteins.
Nieminuszczy J, Sikora A, Wrzesiński M, Janion C, Grzesiuk E. | 01/21/2010 |
| AlkB repairs epsilonA and epsilonC genomic lesions. | AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo.
Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh K, Wishnok JS, Drennan CL, Samson LD, Essigmann JM. | 01/21/2010 |
| crystal structures of substrate and product complexes of E. coli AlkB at resolutions from 1.8 to 2.3 A | Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB.
Yu B, Edstrom WC, Benach J, Hamuro Y, Weber PC, Gibney BR, Hunt JF. | 01/21/2010 |
| AlkB is shown here to be a geno-protective agent that reduces the toxicity of DNA damage by converting the primary adduct to a less toxic secondary product | Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB.
Frick LE, Delaney JC, Wong C, Drennan CL, Essigmann JM., Free PMC Article | 01/21/2010 |