| Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin. | Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.
Alnaas AA, Watson-Siriboe A, Tran S, Negussie M, Henderson JA, Osterberg JR, Chon NL, Harrott BM, Oviedo J, Lyakhova T, Michel C, Reisdorph N, Reisdorph R, Shearn CT, Lin H, Knight JD., Free PMC Article | 08/28/2021 |
| SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer. | SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer.
Liu XY, Jiang W, Ma D, Ge LP, Yang YS, Gou ZC, Xu XE, Shao ZM, Jiang YZ., Free PMC Article | 06/5/2021 |
| LMP1 upregulates SDC2 and SYTL4. | Epstein-Barr virus-encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan-2 and synaptotagmin-like-4 in nasopharyngeal carcinoma cells.
Liao C, Zhou Q, Zhang Z, Wu X, Zhou Z, Li B, Peng J, Shen L, Li D, Luo X, Yang L., Free PMC Article | 03/21/2020 |
| Determined the solution structure of human synaptotagmin-like protein 4 (Slp4). Through modification of cysteine residues, found Slp4 binding of two zinc atoms is required for correct folding. | The unique N-terminal zinc finger of synaptotagmin-like protein 4 reveals FYVE structure.
Miyamoto K, Nakatani A, Saito K., Free PMC Article | 12/16/2017 |
| Granuphilin makes granules immobile and fusion-reluctant beneath the plasma membrane. Those granuphilin-positive, docked granules release a portion of granuphilin upon fusion, and fuse at a frequency and time course similar to those of granuphilin-negative undocked granules. Granuphilin forms a 180-nm cluster at the site of each docked granule, along with granuphilin-interacting Rab27a and Munc18-1 clusters. | Granuphilin exclusively mediates functional granule docking to the plasma membrane.
Mizuno K, Fujita T, Gomi H, Izumi T., Free PMC Article | 02/18/2017 |
| GLUT5 required an interaction cascade of Rab11, Myo5B, Slp4a, Munc18-2, and Vamp7 with Stx3. | Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
Vogel GF, Klee KM, Janecke AR, Müller T, Hess MW, Huber LA., Free PMC Article | 02/13/2016 |
| Phosphatidylinositol 4,5-bisphosphate binds to the concave surface of granuphilin-C2A domain. The key residues involved in the binding were validated by mutation analysis. | Insights into the molecular recognition of the granuphilin C2A domain with PI(4,5)P2.
Wan C, Wu B, Song Z, Zhang J, Chu H, Wang A, Liu Q, Shi Y, Li G, Wang J. | 11/21/2015 |
| the mechanisms of granuphilin plasma membrane targeting and release | The C2 domains of granuphilin are high-affinity sensors for plasma membrane lipids.
Lyakhova TA, Knight JD., Free PMC Article | 04/4/2015 |
| Recruitment of STXBP1 by the Rab27A effector SYTL4 promotes Weibel-Palade body exocytosis. | STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a.
van Breevoort D, Snijders AP, Hellen N, Weckhuysen S, van Hooren KW, Eikenboom J, Valentijn K, Fernandez-Borja M, Ceulemans B, De Jonghe P, Voorberg J, Hannah M, Carter T, Bierings R. | 07/19/2014 |
| Slp4 and Rab8 are expressed and interact in human platelets, and might be involved in dense granule release. | Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets.
Hampson A, O'Connor A, Smolenski A. | 07/27/2013 |
| in insulin-producing cells adequate levels of mir-9 are mandatory for maintaining appropriate Granuphilin levels and optimal secretory capacity | MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells.
Plaisance V, Abderrahmani A, Perret-Menoud V, Jacquemin P, Lemaigre F, Regazzi R. | 01/21/2010 |
| Synaptotagmin-like protein 4 (Slp4)/granuphilin-a contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp4 specifically and directly binds the GTP-bound form of Rab3A, Rab8, and Rab27A. | The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K. | 04/2/2002 |