| SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis. | SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis.
Yu PC, Hou D, Chang B, Liu N, Xu CH, Chen X, Hu CL, Liu T, Wang X, Zhang Q, Liu P, Jiang Y, Fei MY, Zong LJ, Zhang JY, Liu H, Chen BY, Chen SB, Wang Y, Li ZJ, Li X, Deng CH, Ren YY, Zhao M, Jiang S, Wang R, Jin J, Yang S, Xue K, Shi J, Chang CK, Shen S, Wang Z, He PC, Chen Z, Chen SJ, Sun XJ, Wang L. | 09/13/2024 |
| E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice. | E3 ubiquitin ligase RNF180 mediates the ALKBH5/SMARCA5 axis to promote colon inflammation and Th17/Treg imbalance in ulcerative colitis mice.
Wang K, Liu F, Muchu B, Deng J, Peng J, Xu Y, Li F, Ouyang M. | 09/11/2024 |
| Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice. | Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice.
Qu Y, Zhou N, Zhang X, Li Y, Xu XF., Free PMC Article | 07/7/2023 |
| Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes. | Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes.
Wang J, Zhou H, Shao J, Zhang S, Jin J., Free PMC Article | 06/13/2023 |
| Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. | Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.
Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr, Paces J, Skoultchi AI, Stopka T, Kozmik Z., Free PMC Article | 04/19/2023 |
| Functional roles of the chromatin remodeler SMARCA5 in mouse and bovine preimplantation embryosdagger. | Functional roles of the chromatin remodeler SMARCA5 in mouse and bovine preimplantation embryos†.
Shi Y, Zhao P, Dang Y, Li S, Luo L, Hu B, Wang S, Wang H, Zhang K. | 12/25/2021 |
| Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates. | Smarca5-mediated epigenetic programming facilitates fetal HSPC development in vertebrates.
Ding Y, Wang W, Ma D, Liang G, Kang Z, Xue Y, Zhang Y, Wang L, Heng J, Zhang Y, Liu F., Free PMC Article | 04/24/2021 |
| these results indicate that Smarca5 plays a key role in the development of thymocytes undergoing beta-selection, gammadelta thymocytes, and also B cell progenitors by regulating the transcription of early differentiation programs | ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection.
Zikmund T, Kokavec J, Turkova T, Savvulidi F, Paszekova H, Vodenkova S, Sedlacek R, Skoultchi AI, Stopka T., Free PMC Article | 03/7/2020 |
| demonstrate the importance of Snf2h in oocyte meiotic resumption, but also reveal the mechanism underlying how a chromatin remodeling factor can regulate oocyte meiosis | The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression.
Zhang C, Chen Z, Yin Q, Fu X, Li Y, Stopka T, Skoultchi AI, Zhang Y., Free PMC Article | 02/15/2020 |
| Smarca5 plays indispensable roles during early hematopoiesis and erythropoiesis. | The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.
Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T., Free PMC Article | 02/24/2018 |
| VGF neuropeptides promote oligodendrogenesis in vitro, whereas Snf2h cKO mice treated with full-length VGF-encoding adenoviruses removed the requirement of exercise for survival. | Voluntary Running Triggers VGF-Mediated Oligodendrogenesis to Prolong the Lifespan of Snf2h-Null Ataxic Mice.
Alvarez-Saavedra M, De Repentigny Y, Yang D, O'Meara RW, Yan K, Hashem LE, Racacho L, Ioshikhes I, Bulman DE, Parks RJ, Kothary R, Picketts DJ. | 11/26/2017 |
| Snf2h is essential for the establishment of lens vesicle polarity, partitioning of prospective lens epithelial and fiber cell compartments, lens fiber cell differentiation, and lens fiber cell nuclear degradation. | Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.
He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A., Free PMC Article | 09/2/2017 |
| Snf2h controls chromatin organization and histone H1 dynamics for the establishment of gene expression programs underlying cerebellar morphogenesis and neural maturation. | Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.
Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ., Free PMC Article | 07/25/2015 |
| The results demonstrated a novel role of CECR2-containing complexes in spermatogenesis and showed that CECR2 interacts predominantly with SNF2H instead of SNF2L in the testis. | CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis.
Thompson PJ, Norton KA, Niri FH, Dawe CE, McDermid HE. | 03/24/2012 |
| role for SNF2H in both repression and activation of cytokine genes. | The SNF2H chromatin remodeling enzyme has opposing effects on cytokine gene expression.
Precht P, Wurster AL, Pazin MJ., Free PMC Article | 07/19/2010 |
| Smarca5 is a key regulator of global chromatin structure. | Nuclear localization of ISWI ATPase Smarca5 (Snf2h) in mouse.
Vargova J, Vargova K, Skoultchi AI, Stopka T., Free PMC Article | 06/28/2010 |
| Smarca5-NoRC complex has a role in heterochromatin formation and silencing of ribosomal gene transcription | The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription.
Santoro R, Li J, Grummt I. | 01/21/2010 |
| Snf2h-/- embryos die during the periimplantation stage. Blastocyst outgrowth experiments indicate that loss of Snf2h results in growth arrest and cell death of both the trophectoderm and inner cell mass. | The ISWI ATPase Snf2h is required for early mouse development.
Stopka T, Skoultchi AI., Free PMC Article | 01/21/2010 |