| Modulation of insulin secretion by RBFOX2-mediated alternative splicing. | Modulation of insulin secretion by RBFOX2-mediated alternative splicing.
Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L., Free PMC Article | 11/29/2023 |
| Suppression of RBFox2 by Multiple MiRNAs in Pressure Overload-Induced Heart Failure. | Suppression of RBFox2 by Multiple MiRNAs in Pressure Overload-Induced Heart Failure.
Gu M, Zhao Y, Wang H, Cheng W, Liu J, Ouyang K, Wei C., Free PMC Article | 01/28/2023 |
| Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice. | Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice.
Paterson HAB, Yu S, Artigas N, Prado MA, Haberman N, Wang YF, Jobbins AM, Pahita E, Mokochinski J, Hall Z, Guerin M, Paulo JA, Ng SS, Villarroya F, Rashid ST, Le Goff W, Lenhard B, Cebola I, Finley D, Gygi SP, Sibley CR, Vernia S., Free PMC Article | 12/31/2022 |
| RBFOX2 is required for establishing RNA regulatory networks essential for heart development. | RBFOX2 is required for establishing RNA regulatory networks essential for heart development.
Verma SK, Deshmukh V, Thatcher K, Belanger KK, Rhyner AM, Meng S, Holcomb RJ, Bressan M, Martin JF, Cooke JP, Wythe JD, Widen SG, Lincoln J, Kuyumcu-Martinez MN., Free PMC Article | 05/7/2022 |
| Expression of the alternative splicing regulator Rbfox2 during placental development is differentially regulated in preeclampsia mouse models. | Expression of the alternative splicing regulator Rbfox2 during placental development is differentially regulated in preeclampsia mouse models.
Freitag N, Xie Y, Adam LM, Borowski S, Blois SM, Barrientos G. | 04/2/2022 |
| The effect of Rbfox2 modulation on retinal transcriptome and visual function. | The effect of Rbfox2 modulation on retinal transcriptome and visual function.
Gu L, Kawaguchi R, Caprioli J, Piri N., Free PMC Article | 01/2/2021 |
| Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity. | Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity.
Begg BE, Jens M, Wang PY, Minor CM, Burge CB., Free PMC Article | 12/19/2020 |
| Expression of Rbfox2 is essential for proper exon splicing of genes of the cGMP-PKG-Ca2+ pathway. | Genes of the cGMP-PKG-Ca(2+) signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2.
Wan X, Belanger K, Widen SG, Kuyumcu-Martinez MN, Garg NJ., Free PMC Article | 08/12/2020 |
| Here, the authors demonstrate that splicing factor Rbfox2 is expressed in the neural crest cells (NCCs), and deletion of Rbfox2 in NCCs leads to cleft palate and defects in craniofacial bone development. RNA-Seq analysis revealed that Rbfox2 regulates splicing and expression of numerous genes essential for neural crest/craniofacial development. | Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate.
Cibi DM, Mia MM, Guna Shekeran S, Yun LS, Sandireddy R, Gupta P, Hota M, Sun L, Ghosh S, Singh MK., Free PMC Article | 02/22/2020 |
| Rbfox deletion did not cause a reduction in global protein synthesis, but it led to altered splicing of hundreds of gene transcripts, including capn3, which produced an active form of calpain3 protease. | Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.
Singh RK, Kolonin AM, Fiorotto ML, Cooper TA., Free PMC Article | 12/14/2019 |
| RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure | RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure.
Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, Gou LT, Zhou Y, Zhang J, Ren S, Chen J, Wang Y, Fu XD., Free PMC Article | 06/1/2019 |
| These data reveal an alternative splicing program activated by Rbfox2 in the endothelium on recruitment of platelets and macrophages and demonstrate its relevance in transcriptional responses during flow-driven vascular inflammation. | Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.
Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO., Free PMC Article | 09/1/2018 |
| This study demonstrated that the Rbfox2 represses e18a inclusion during pre-mRNA splicing of CaV2.2, limiting the size of CaV2.2 currents early in development in certain neuronal populations. | Cell-Specific RNA Binding Protein Rbfox2 Regulates Ca(V)2.2 mRNA Exon Composition and Ca(V)2.2 Current Size.
Allen SE, Toro CP, Andrade A, López-Soto EJ, Denome S, Lipscombe D., Free PMC Article | 06/16/2018 |
| RBFOX2 dysregulation by dominant-negative RBFOX2 is an early pathogenic event in diabetic hearts. | Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes.
Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN., Free PMC Article | 09/23/2017 |
| RBFox2 interactis with chromatin in a nascent RNA-dependent manner. RBFox2 inactivation eradicates PRC2 targeting on the majority of bivalent gene promoters and leads to transcriptional de-repression. | RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes.
Wei C, Xiao R, Chen L, Cui H, Zhou Y, Xue Y, Hu J, Zhou B, Tsutsui T, Qiu J, Li H, Tang L, Fu XD., Free PMC Article | 08/26/2017 |
| A classic nuclear localization signal at the N terminus that regulates the subcellular localization of Rbfox2 isoforms during differentiation of the mouse epithelial and embryonic stem cells lines has been identified. | Identification of a classic nuclear localization signal at the N terminus that regulates the subcellular localization of Rbfox2 isoforms during differentiation of NMuMG and P19 cells.
Wenzel M, Schüle M, Casanovas S, Strand D, Strand S, Winter J. | 05/20/2017 |
| Gain- and loss-of-function experiments demonstrated that Rbfox1 and Rbfox2 cooperate in promoting Mef2D splicing and subsequent myogenesis. | Rbfox proteins regulate tissue-specific alternative splicing of Mef2D required for muscle differentiation.
Runfola V, Sebastian S, Dilworth FJ, Gabellini D., Free PMC Article | 04/2/2016 |
| Results show that the conserved Rbfox2 RNA binding protein regulates 30% of the splicing transitions observed during myogenesis and is required for the specific step of myoblast fusion. | Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis.
Singh RK, Xia Z, Bland CS, Kalsotra A, Scavuzzo MA, Curk T, Ule J, Li W, Cooper TA., Free PMC Article | 10/25/2014 |
| an unexpectedly broad and multilayer regulatory network controlled by Rbfox2 and offer an explanation for how autoregulatory splicing networks are tuned | Rbfox2 controls autoregulation in RNA-binding protein networks.
Jangi M, Boutz PL, Paul P, Sharp PA., Free PMC Article | 05/3/2014 |
| During an EMT, Rbfox2-regulated splicing shifts from epithelial-to mesenchymal-specific events. | The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion.
Braeutigam C, Rago L, Rolke A, Waldmeier L, Christofori G, Winter J. | 04/26/2014 |
| Rbfox2 protein controls a post-transcriptional program required for proper brain development. | The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.
Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M Jr, Otis TS, Black DL., Free PMC Article | 04/21/2012 |
| the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism | NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2.
Dredge BK, Jensen KB., Free PMC Article | 11/5/2011 |
| The present study provides evidence that alternative neuronal nPTB and Fox-1/Fox-2 isoforms are also produced in lenses | Evidence that "brain-specific" FOX-1, FOX-2, and nPTB alternatively spliced isoforms are produced in the lens.
Bitel CL, Nathan R, Wong P, Kuppasani S, Matsushita M, Kanazawa H, Frederikse PH. | 07/2/2011 |
| Fox-1 and Fox-2 isoforms specifically activate splicing of neuronally regulated exons, which requires UGCAUG enhancer elements | Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals.
Underwood JG, Boutz PL, Dougherty JD, Stoilov P, Black DL., Free PMC Article | 01/21/2010 |