| High frequency of heterozygous rare variants of the SLC34A1 and SLC9A3R1 genes in patients with atypical femur fracture. | High frequency of heterozygous rare variants of the SLC34A1 and SLC9A3R1 genes in patients with atypical femur fracture.
Marini F, Giusti F, Marasco E, Xumerle L, Kwiatkowska KM, Garagnani P, Biver E, Ferrari S, Iolascon G, Iantomasi T, Brandi ML. | 02/23/2023 |
| RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein. | RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein.
Friedman PA, Sneddon WB, Mamonova T, Montanez-Miranda C, Ramineni S, Harbin NH, Squires KE, Gefter JV, Magyar CE, Emlet DR, Hepler JR., Free PMC Article | 06/11/2022 |
| Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly. | Cotranslational interaction of human EBP50 and ezrin overcomes masked binding site during complex assembly.
Khan K, Long B, Baleanu-Gogonea C, Gogonea V, Deshpande GM, Vasu K, Fox PL., Free PMC Article | 03/12/2022 |
| Nuclear expression of NHERF1/EBP50 in Clear Cell Renal Cell Carcinoma. | Nuclear expression of NHERF1/EBP50 in Clear Cell Renal Cell Carcinoma.
Lema BE, Patricio GM, Kreimann EL. | 01/15/2022 |
| Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma. | Cytoplasmic EBP50 and elevated PARP1 are unfavorable prognostic factors in ovarian clear cell carcinoma.
Matsumoto T, Yoki A, Konno R, Oguri Y, Hashimura M, Tochimoto M, Nakagawa M, Jiang Z, Ishibashi Y, Ito T, Kodera Y, Saegusa M. | 01/1/2022 |
| Na(+)/H(+) Exchanger Regulatory Factor 1 Mediates the Pathogenesis of Airway Inflammation in a Murine Model of House Dust Mite-Induced Asthma. | Na(+)/H(+) Exchanger Regulatory Factor 1 Mediates the Pathogenesis of Airway Inflammation in a Murine Model of House Dust Mite-Induced Asthma.
Kammala AK, Bahal D, Yang C, Panettieri RA Jr, Das R, Subramanian H., Free PMC Article | 09/18/2021 |
| Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport. | Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport.
Vistrup-Parry M, Sneddon WB, Bach S, Strømgaard K, Friedman PA, Mamonova T., Free PMC Article | 08/28/2021 |
| Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport: Binding Outside the Box. | Noncanonical Sequences Involving NHERF1 Interaction with NPT2A Govern Hormone-Regulated Phosphate Transport: Binding Outside the Box.
Mamonova T, Friedman PA., Free PMC Article | 05/29/2021 |
| Sodium Hydrogen Exchanger Regulatory Factor-1 (NHERF1) Regulates Fetal Membrane Inflammation. | Sodium Hydrogen Exchanger Regulatory Factor-1 (NHERF1) Regulates Fetal Membrane Inflammation.
Kammala AK, Sheller-Miller S, Radnaa E, Kechichian T, Subramanian H, Menon R., Free PMC Article | 03/6/2021 |
| In vivo crystals reveal critical features of the interaction between cystic fibrosis transmembrane conductance regulator (CFTR) and the PDZ2 domain of Na(+)/H(+) exchange cofactor NHERF1. | In vivo crystals reveal critical features of the interaction between cystic fibrosis transmembrane conductance regulator (CFTR) and the PDZ2 domain of Na(+)/H(+) exchange cofactor NHERF1.
Martin ER, Barbieri A, Ford RC, Robinson RC., Free PMC Article | 01/2/2021 |
| Alteration in the sensitivity to crizotinib by Na(+)/H(+) exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers. | Alteration in the sensitivity to crizotinib by Na(+)/H(+) exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers.
Yang F, Hu M, Chang S, Huang J, Si Y, Wang J, Cheng S, Jiang WG., Free PMC Article | 11/21/2020 |
| assessed the role of NHERF1 in regulating cAMP-mediated signaling and immunomodulatory functions in airway smooth muscle | Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle.
Pera T, Tompkins E, Katz M, Wang B, Deshpande DA, Weinman EJ, Penn RB., Free PMC Article | 06/6/2020 |
| findings provide important insight into the modulation of the intrinsic flexibility of NHERF1 by disease-associated point mutations that alter the dynamic assembly of signaling complexes | Dynamic structure of the full-length scaffolding protein NHERF1 influences signaling complex assembly.
Bhattacharya S, Stanley CB, Heller WT, Friedman PA, Bu Z., Free PMC Article | 04/4/2020 |
| Dephosphorylated NHERF1 exhibited faster exchange at C-terminal residues suggesting that NHERF1 dephosphorylation precedes Ser(290) rephosphorylation | Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
Zhang Q, Xiao K, Paredes JM, Mamonova T, Sneddon WB, Liu H, Wang D, Li S, McGarvey JC, Uehling D, Al-Awar R, Joseph B, Jean-Alphonse F, Orte A, Friedman PA., Free PMC Article | 12/14/2019 |
| loss of EBP50 may therefore be a surrogate biomarker for high-risk human papilloma virus infection in oropharyngeal tumours. | Ezrin-Radixin-Moesin Binding Phosphoprotein 50: A Potential Novel Biomarker in Human Papilloma Virus-Associated Head and Neck Squamous Cell Carcinomas.
Shankar A, Crouch DH, Macluskey M., Free PMC Article | 12/7/2019 |
| NHERF1 inhibits Wnt signaling-mediated proliferation of cervical cancer via suppression of ACTN4, and NHERF1 downregulation may contribute to the progression of cervical cancer. | NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression.
Wang Q, Qin Q, Song R, Zhao C, Liu H, Yang Y, Gu S, Zhou D, He J., Free PMC Article | 12/7/2019 |
| The results suggested that NHERF1 played an essential role in regulating liver cancer progression, and repressing NHERF1 expression exhibited significant anticancer effects via the induction of G0/G1 phase arrest, apoptosis and reactive oxygen species generation. | Repressing of NHERF1 inhibits liver cancer progression by promoting the production of ROS.
Sun J, Li P, Yang J. | 10/12/2019 |
| Low NHERF1 expression is associated with hypophosphatemia in calcium stone formers. | Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers.
Bergsland KJ, Coe FL, Parks JH, Asplin JR, Worcester EM., Free PMC Article | 08/17/2019 |
| NHERF1 was found to be downregulated by HPV16 E6 rather than by HPV18 E6, leading to enhancement of ACTN4-mediated actin cytoskeleton organization, motility and invasion of cervical cancer cells both in vitro and in vivo. Thus, the enhancement of cell migration and invasion induced by HPV16 E6-mediated degradation of NHERF1 might be an important cause of cervical cancer carcinogenesis. | HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1.
Wang Q, Song R, Zhao C, Liu H, Yang Y, Gu S, Feng D, He J. | 05/25/2019 |
| NHERF1 role in the colorectal cancer apoptosis.CTNNB1 represses NHERF1 expression by associating with TCF4 in colorectal cancer. | β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy.
Saponaro C, Sergio S, Coluccia A, De Luca M, La Regina G, Mologni L, Famiglini V, Naccarato V, Bonetti D, Gautier C, Gianni S, Vergara D, Salzet M, Fournier I, Bucci C, Silvestri R, Passerini CG, Maffia M, Coluccia AML., Free PMC Article | 03/2/2019 |
| DNMT1 contributes to promoter hypermethylation and epigenetic NHERF1 silencing in colon cancer. | Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.
Guo Y, Wang M, Jia X, Zhu H, Zhi Y, Yuan L. | 10/13/2018 |
| found that NHERF1 was associated with trophoblast differentiation and motility; stepwise experimental platform to explore new functions of ambiguously denoted candidate proteins | Systematic Proteogenomic Approach To Exploring a Novel Function for NHERF1 in Human Reproductive Disorder: Lessons for Exploring Missing Proteins.
Na K, Shin H, Cho JY, Jung SH, Lim J, Lim JS, Kim EA, Kim HS, Kang AR, Kim JH, Shin JM, Jeong SK, Kim CY, Park JY, Chung HM, Omenn GS, Hancock WS, Paik YK., Free PMC Article | 08/18/2018 |
| High expression of NHERF-1 is associated with triple-negative breast cancer. | NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling.
Wang Y, Peng Z, Meng R, Tao T, Wang Q, Zhao C, Liu H, Song R, Zheng J, Qin Q, He J. | 05/19/2018 |
| Taken together, these findings suggest that the high dynamics of cytosolic NHERF1 provide cancer cells with a means of controlling chemotactic migration. | Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.
Oh YS, Heo K, Kim EK, Jang JH, Bae SS, Park JB, Kim YH, Song M, Kim SR, Ryu SH, Kim IH, Suh PG., Free PMC Article | 04/14/2018 |
| Studies support a role for NHERF-1 and NHERF-2 (Na+/H+ exchanger regulatory factors 1 and 2) in regulating the distribution of Group II metabotropic glutamate receptor (mGluRs) in the murine brain, while conversely the effects of the mGluR2/3 PDZ-binding motifs on receptor signaling are likely mediated by interactions with other PDZ scaffold proteins beyond the NHERF proteins. | Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain.
Ritter-Makinson SL, Paquet M, Bogenpohl JW, Rodin RE, Chris Yun C, Weinman EJ, Smith Y, Hall RA., Free PMC Article | 03/17/2018 |