| Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth. | Comprehensive split TEV based protein-protein interaction screening reveals TAOK2 as a key modulator of Hippo signalling to limit growth.
Ma X, Mandausch FJ, Wu Y, Sahoo VK, Ma W, Leoni G, Hostiuc M, Wintgens JP, Qiu J, Kannaiyan N, Rossner MJ, Wehr MC. | 12/5/2023 |
| The circRNA circSIAE Inhibits Replication of Coxsackie Virus B3 by Targeting miR-331-3p and Thousand and One Amino-Acid Kinase 2. | The circRNA circSIAE Inhibits Replication of Coxsackie Virus B3 by Targeting miR-331-3p and Thousand and One Amino-Acid Kinase 2.
Yang Q, Li Y, Wang Y, Qiao X, Liu T, Wang H, Shen H., Free PMC Article | 04/9/2022 |
| TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. | TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules.
Nourbakhsh K, Ferreccio AA, Bernard MJ, Yadav S., Free PMC Article | 01/15/2022 |
| we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 nmol/L, is ATP-competitive, and targets these kinases selectively. TAOK inhibition or depletion in centrosome-amplified SKBR3 or BT549 breast cancer cell models increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindles, induces cell death, and inhibits cell growt | Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.
Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, Linardopoulos S, Tutt AN, Morris JDH. | 07/28/2018 |
| tau is a good substrate for PSK1 and PSK2 phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases. | Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.
Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP, Morris JD., Free PMC Article | 08/10/2013 |
| TAOK2 is essential for dendrite morphogenesis; TAOK2 downregulation impairs basal dendrite formation without affecting apical dendrites. | Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH., Free PMC Article | 09/8/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Association and mutation analyses of 16p11.2 autism candidate genes.
Kumar RA, Marshall CR, Badner JA, Babatz TD, Mukamel Z, Aldinger KA, Sudi J, Brune CW, Goh G, Karamohamed S, Sutcliffe JS, Cook EH, Geschwind DH, Dobyns WB, Scherer SW, Christian SL., Free PMC Article | 03/25/2009 |
| PSK1-alpha is a bifunctional kinase that associates with microtubules, and JNK- and caspase-mediated removal of its C-terminal microtubule-binding domain permits nuclear translocation of the N-terminal region of PSK1-alpha and its induction of apoptosis | Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing.
Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD. | 01/21/2010 |
| the TAK1-JNK pathway is activated by osmotic stress, while blocking TAK1-mediated NF-kappaB activation; TAO2 regulates TAK1 pathways | Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.
Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J., Free PMC Article | 01/21/2010 |
| mediates signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors | TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.
Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH. | 01/21/2010 |
| PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity | The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.
Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD. | 01/21/2010 |