| Modulation of PI3K/Akt/GSK3beta signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction. | Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction.
Ahmed S, Abir AH, Sharmin O, Khurshid N, Akter A, Nakshy NT, Hasan MM, Yesmine S, Rahman M. | 11/29/2023 |
| Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived Glioblastoma Cells. | Elucidation of GPR55-Associated Signaling behind THC and LPI Reducing Effects on Ki67-Immunoreactive Nuclei in Patient-Derived Glioblastoma Cells.
Kolbe MR, Hohmann T, Hohmann U, Maronde E, Golbik R, Prell J, Illert J, Strauss C, Dehghani F., Free PMC Article | 11/27/2023 |
| A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma. | A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma.
Wang T, Xia K, Qiu T, Han S, Chen Z, Ma X, Zhang L, Zou J, Zhang Y, Yu B, Kong C, Guo J, Liu Y, Zhou J, Zheng S., Free PMC Article | 09/25/2023 |
| Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages. | Lysophosphatidylglucoside/GPR55 signaling promotes foam cell formation in human M2c macrophages.
Shimai R, Hanafusa K, Nakayama H, Oshima E, Kato M, Kano K, Matsuo I, Miyazaki T, Tokano T, Hirabayashi Y, Iwabuchi K, Minamino T., Free PMC Article | 08/9/2023 |
| Prognostic Significance of GPR55 mRNA Expression in Colon Cancer. | Prognostic Significance of GPR55 mRNA Expression in Colon Cancer.
Ismail HTH, AbdelMageed M, Lindmark G, Hammarström ML, Hammarström S, Sitohy B., Free PMC Article | 05/21/2022 |
| Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma. | Expression of the putative cannabinoid receptor GPR55 is increased in endometrial carcinoma.
Ayakannu T, Taylor AH, Konje JC., Free PMC Article | 03/12/2022 |
| Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning. | Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning.
Mosca MG, Mangini M, Cioffi S, Barba P, Mariggiò S., Free PMC Article | 01/29/2022 |
| Gene Expression Data Mining Reveals the Involvement of GPR55 and Its Endogenous Ligands in Immune Response, Cancer, and Differentiation. | Gene Expression Data Mining Reveals the Involvement of GPR55 and Its Endogenous Ligands in Immune Response, Cancer, and Differentiation.
Wnorowski A, Wójcik J, Maj M., Free PMC Article | 01/15/2022 |
| Lysophosphatidylglucoside is a GPR55 -mediated chemotactic molecule for human monocytes and macrophages. | Lysophosphatidylglucoside is a GPR55 -mediated chemotactic molecule for human monocytes and macrophages.
Li X, Hanafusa K, Kage M, Yokoyama N, Nakayama H, Hotta T, Oshima E, Kano K, Matsuo I, Nagatsuka Y, Takamori K, Ogawa H, Hirabayashi Y, Iwabuchi K. | 11/27/2021 |
| Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P5 in live cells. | Interactions between lysophosphatidylinositol receptor GPR55 and sphingosine-1-phosphate receptor S1P(5) in live cells.
Hong H, Yoon B, Ghil S. | 11/22/2021 |
| The L-alpha-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis. | The L-α-Lysophosphatidylinositol/G Protein-Coupled Receptor 55 System Induces the Development of Nonalcoholic Steatosis and Steatohepatitis.
Fondevila MF, Fernandez U, Gonzalez-Rellan MJ, Da Silva Lima N, Buque X, Gonzalez-Rodriguez A, Alonso C, Iruarrizaga-Lejarreta M, Delgado TC, Varela-Rey M, Senra A, Garcia-Outeiral V, Novoa E, Iglesias C, Porteiro B, Beiroa D, Folgueira C, Tojo M, Torres JL, Hernández-Cosido L, Blanco Ó, Arab JP, Barrera F, Guallar D, Fidalgo M, López M, Dieguez C, Marcos M, Martinez-Chantar ML, Arrese M, Garcia-Monzon C, Mato JM, Aspichueta P, Nogueiras R., Free PMC Article | 08/14/2021 |
| BRET analysis reveals interaction between the lysophosphatidic acid receptor LPA2 and the lysophosphatidylinositol receptor GPR55 in live cells. | BRET analysis reveals interaction between the lysophosphatidic acid receptor LPA2 and the lysophosphatidylinositol receptor GPR55 in live cells.
Bang G, Ghil S. | 07/17/2021 |
| Expression of Lysophosphatidylinositol Signaling-relevant Molecules in Colorectal Cancer. | Expression of Lysophosphatidylinositol Signaling-relevant Molecules in Colorectal Cancer.
Kitamura C, Sonoda H, Anzai H, Nagai Y, Abe S, Yokoyama Y, Ishii H, Kishikawa J, Emoto S, Murono K, Sasaki K, Kawai K, Nozawa H, Ishihara S. | 05/22/2021 |
| Ginseng Gintonin Contains Ligands for GPR40 and GPR55. | Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
Cho YJ, Choi SH, Lee R, Hwang H, Rhim H, Cho IH, Kim HC, Lee JI, Hwang SH, Nah SY., Free PMC Article | 12/12/2020 |
| The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling. | The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.
Ruz-Maldonado I, Liu B, Atanes P, Pingitore A, Huang GC, Choudhary P, Persaud SJ., Free PMC Article | 11/21/2020 |
| The authors conclude that hepatitis C virus induces lncR 8 expression, while lncR 8 indirectly favors hepatitis C virus replication by stimulating expression of its neighboring gene GPR55, which in turn downregulates expression of ISGs. The latter fact is also consistent with an anti-inflammatory role of GPR55. | Lnc-ITM2C-1 and GPR55 Are Proviral Host Factors for Hepatitis C Virus.
Hu P, Wilhelm J, Gerresheim GK, Shalamova LA, Niepmann M., Free PMC Article | 07/25/2020 |
| hypertension can be mitigated via CB1 agonism and impaired adrenoceptor responsiveness prevented by functional GPR55. | Cannabinoid-sensitive receptors in cardiac physiology and ischaemia.
Puhl SL. | 07/4/2020 |
| Study found GPR55 expression downregulated in salivary gland mucoepidermoid carcinomas and GPR55 reinstatement by antitumor irradiation, suggesting that GPR55 controls renegade proliferation. GPR55 antagonism increases cell proliferation and function determination in quasiphysiological systems. GPR55 signaling in epithelial cells ensures both the life-long renewal of ductal cells and the continuous availability of saliva | GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation.
Korchynska S, Lutz MI, Borók E, Pammer J, Cinquina V, Fedirko N, Irving AJ, Mackie K, Harkany T, Keimpema E., Free PMC Article | 05/16/2020 |
| Results provide evidence that l-alpha-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway. | l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway.
Robertson-Gray OJ, Walsh SK, Ryberg E, Jönsson-Rylander AC, Lipina C, Wainwright CL., Free PMC Article | 02/8/2020 |
| Our findings support the hypothesis that neural stem cells (NSC) express functional GPR55 and that targeting GPR55 with selective agonists increases NSC proliferation and early neurogenesis both in vitro and in vivo. A better understanding of the role GPR55 plays during neurogenesis may provide new prospects for therapeutic treatments utilizing this receptor as a target. | Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis.
Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Persidsky Y., Free PMC Article | 10/5/2019 |
| The GPR55 gene expressions were significantly lower in the Dorsolateral Prefrontal Cortex of suicide cases. | Alterations in Gene and Protein Expression of Cannabinoid CB(2) and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims.
García-Gutiérrez MS, Navarrete F, Navarro G, Reyes-Resina I, Franco R, Lanciego JL, Giner S, Manzanares J., Free PMC Article | 03/16/2019 |
| GPR55 is involved in the migratory behavior of human breast cancer cells. | The LPI/GPR55 axis enhances human breast cancer cell migration via HBXIP and p-MLC signaling.
Zhou XL, Guo X, Song YP, Zhu CY, Zou W., Free PMC Article | 09/29/2018 |
| Inhibition of GPR55 activity produces antitumor effects via attenuation of the MEK/ERK and PI3K-AKT pathways leading to a reduction in the expression and function of MDR proteins. | Selective GPR55 antagonism reduces chemoresistance in cancer cells.
Singh NS, Bernier M, Wainer IW., Free PMC Article | 12/23/2017 |
| our data suggest that GPR55 and CB1 play differential roles in colon carcinogenesis where the former seems to act as oncogene and the latter as tumor suppressor. | G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1.
Hasenoehrl C, Feuersinger D, Sturm EM, Bärnthaler T, Heitzer E, Graf R, Grill M, Pichler M, Beck S, Butcher L, Thomas D, Ferreirós N, Schuligoi R, Schweiger C, Haybaeck J, Schicho R., Free PMC Article | 11/25/2017 |
| GPR55 was highly expressed by beta-cells of both humans and mice. It was also present in a small proportion of mouse islet alpha-cells and in the majority of human islet alpha-cells, but it was absent or at very low levels in delta-cells of both species. GPR55 was preferentially expressed in the endocrine pancreas, with only faint immunoreactivity in the exocrine pancreas in mice and humans. | GPR55-dependent stimulation of insulin secretion from isolated mouse and human islets of Langerhans.
Liu B, Song S, Ruz-Maldonado I, Pingitore A, Huang GC, Baker D, Jones PM, Persaud SJ. | 11/11/2017 |