| Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation. | Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation.
Su VL, Simon B, Draheim KM, Calderwood DA., Free PMC Article | 10/24/2020 |
| ICAP-1 monoubiquitylation helps in switching from ROCK2-mediated to MRCKalpha-mediated cell contractility. | ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance.
Bouin AP, Kyumurkov A, Régent-Kloeckner M, Ribba AS, Faurobert E, Fournier HN, Bourrin-Reynard I, Manet-Dupé S, Oddou C, Balland M, Planus E, Albiges-Rizo C. | 08/5/2017 |
| nuclear-cytoplasmic shuttling of ICAP1 influences both integrin activation and KRIT1 localization, presumably impacting nuclear functions of KRIT1. | Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus.
Draheim KM, Huet-Calderwood C, Simon B, Calderwood DA., Free PMC Article | 06/3/2017 |
| The cocrystal structure of ICAP1 in complex with krev interaction trapped protein (KRIT)1 is characterized here. | Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide.
Liu W, Boggon TJ., Free PMC Article | 02/8/2014 |
| The structural basis for KRIT1 antagonized ICAP1-modulated integrin-beta1 activation. | Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.
Liu W, Draheim KM, Zhang R, Calderwood DA, Boggon TJ., Free PMC Article | 04/20/2013 |
| Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. | Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway.
Cheng TY, Wu MS, Lin JT, Lin MT, Shun CT, Huang HY, Hua KT, Kuo ML. | 03/9/2013 |
| Identify ICAP1 as a novel regulator to prevent excessive sprouting angiogenesis. | Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.
Brütsch R, Liebler SS, Wüstehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A. | 10/4/2010 |
| integrin cytoplasmic domain-associated protein-1 alpha (icap1alpha) act concordantly to play a critical role in beta1-integrin-mediated cell proliferation. | Krit1 modulates beta 1-integrin-mediated endothelial cell proliferation.
Zhang J, Basu S, Rigamonti D, Dietz HC, Clatterbuck RE. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD., Free PMC Article | 02/11/2009 |
| ICAP-1 shuttles between the nucleus and cytoplasm in a beta1 integrin-dependent manner | Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.
Fournier HN, Dupé-Manet S, Bouvard D, Luton F, Degani S, Block MR, Retta SF, Albiges-Rizo C., Free PMC Article | 01/21/2010 |
| beta(1) integrin viability signal in collagen matrices is transduced by focal adhesion kinase | Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway.
Xia H, Nho RS, Kahm J, Kleidon J, Henke CA. | 01/21/2010 |
| Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required for the Icap1 alpha-beta(1) integrin interaction | Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin.
Chang DD, Hoang BQ, Liu J, Springer TA. | 01/21/2010 |
| TNF-alpha induced expression of c-IAP1 and c-IAP2 via MAP kinases, but not via NF-kappaB, and that MAP kinases participated in the inhibition of apoptosis by induction of c-IAPs in TNF-alpha-stimulated endothelial cells | MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha.
Furusu A, Nakayama K, Xu Q, Konta T, Kitamura M. | 01/21/2010 |
| Integrin-binding protein also interacts with Krit 1 protein, cause of CCM1. (ICAP-1, integrin cytoplasmic domain-associated protein 1) | KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
Zawistowski JS, Serebriiskii IG, Lee MF, Golemis EA, Marchuk DA. | 01/21/2010 |