| NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. | NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart.
Müller M, Eghbalian R, Boeckel JN, Frese KS, Haas J, Kayvanpour E, Sedaghat-Hamedani F, Lackner MK, Tugrul OF, Ruppert T, Tappu R, Martins Bordalo D, Kneuer JM, Piekarek A, Herch S, Schudy S, Keller A, Grammes N, Bischof C, Klinke A, Cardoso-Moreira M, Kaessmann H, Katus HA, Frey N, Steinmetz LM, Meder B., Free PMC Article | 10/29/2022 |
| Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease. | Study on the Expression of lncRNA ATB and Nek9 in Breast Cancer Patients Based on Q-PCR Technology and Its Relationship with the Disease.
Zhaoyu Z, Huanyu X, Yajie Z, Ziyu D, Hui L, Feng S., Free PMC Article | 08/13/2022 |
| Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series. | Three novel pathogenic NEK9 variants in patients with nevus comedonicus: A case series.
Juratli HA, Jägle S, Theiler M, Didona D, Happle R, Knöpfel N, Weibel L, Fischer J. | 04/30/2022 |
| NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation. | NEK9, a novel effector of IL-6/STAT3, regulates metastasis of gastric cancer by targeting ARHGEF2 phosphorylation.
Lu G, Tian S, Sun Y, Dong J, Wang N, Zeng J, Nie Y, Wu K, Han Y, Feng B, Shang Y., Free PMC Article | 08/21/2021 |
| The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer. | The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer.
Nie H, Huang PQ, Jiang SH, Yang Q, Hu LP, Yang XM, Li J, Wang YH, Li Q, Zhang YF, Zhu L, Zhang YL, Yu Y, Xiao GG, Sun YW, Ji J, Zhang ZG., Free PMC Article | 07/31/2021 |
| EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7. | EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.
O'Regan L, Barone G, Adib R, Woo CG, Jeong HJ, Richardson EL, Richards MW, Muller PAJ, Collis SJ, Fennell DA, Choi J, Bayliss R, Fry AM., Free PMC Article | 06/26/2021 |
| Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer. | Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.
Xu Z, Shen W, Pan A, Sun F, Zhang J, Gao P, Li L. | 12/19/2020 |
| NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1. | NIMA-related kinase 9-mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1.
Shrestha BK, Skytte Rasmussen M, Abudu YP, Bruun JA, Larsen KB, Alemu EA, Sjøttem E, Lamark T, Johansen T., Free PMC Article | 09/19/2020 |
| This study supports a role for NEK9 and MAP2K4 in mediating buparlisib resistance and demonstrates the value of unbiased omic analyses in uncovering resistance mechanisms to targeted therapy in Triple-Negative Breast Cancers. | Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers.
Mundt F, Rajput S, Li S, Ruggles KV, Mooradian AD, Mertins P, Gillette MA, Krug K, Guo Z, Hoog J, Erdmann-Gilmore P, Primeau T, Huang S, Edwards DP, Wang X, Wang X, Kawaler E, Mani DR, Clauser KR, Gao F, Luo J, Davies SR, Johnson GL, Huang KL, Yoon CJ, Ding L, Fenyö D, Ellis MJ, Townsend RR, Held JM, Carr SA, Ma CX., Free PMC Article | 06/15/2019 |
| Eg5 localization and centrosome separation in prophase depend on the nuclear microtubule-associated protein TPX2, a pool of which localizes to the centrosomes before nuclear envelope breakdown. This localization involves the kinase Nek9, which phosphorylates TPX2 nuclear localization signal preventing its interaction with importin and nuclear import. | Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown.
Eibes S, Gallisà-Suñé N, Rosas-Salvans M, Martínez-Delgado P, Vernos I, Roig J. | 05/11/2019 |
| High expression level of NEK9 is associated with recurrence in glioblastoma. | Survival kinase genes present prognostic significance in glioblastoma.
Varghese RT, Liang Y, Guan T, Franck CT, Kelly DF, Sheng Z., Free PMC Article | 01/20/2018 |
| Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. | A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
Cullati SN, Kabeche L, Kettenbach AN, Gerber SA., Free PMC Article | 09/30/2017 |
| Recessive NEK9 mutation is associated with lethal skeletal dysplasia. | Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.
Casey JP, Brennan K, Scheidel N, McGettigan P, Lavin PT, Carter S, Ennis S, Dorkins H, Ghali N, Blacque OE, Mc Gee MM, Murphy H, Lynch SA. | 08/19/2017 |
| Somatic Mutations in NEK9 Cause Nevus Comedonicus. | Somatic Mutations in NEK9 Cause Nevus Comedonicus.
Levinsohn JL, Sugarman JL, Yale Center for Mendelian Genomics, McNiff JM, Antaya RJ, Choate KA., Free PMC Article | 05/20/2017 |
| Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 target gene expression. | The Dual Nature of Nek9 in Adenovirus Replication.
Jung R, Radko S, Pelka P., Free PMC Article | 06/11/2016 |
| The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization. | Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization.
Haq T, Richards MW, Burgess SG, Gallego P, Yeoh S, O'Regan L, Reverter D, Roig J, Fry AM, Bayliss R., Free PMC Article | 05/21/2016 |
| The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53. | NEK9-dependent proliferation of cancer cells lacking functional p53.
Kurioka D, Takeshita F, Tsuta K, Sakamoto H, Watanabe S, Matsumoto K, Watanabe M, Nakagama H, Ochiya T, Yokota J, Kohno T, Tsuchiya N., Free PMC Article | 11/7/2015 |
| NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint control. | NEK9 depletion induces catastrophic mitosis by impairment of mitotic checkpoint control and spindle dynamics.
Kaneta Y, Ullrich A. | 05/3/2014 |
| Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence | Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation.
Gallego P, Velazquez-Campoy A, Regué L, Roig J, Reverter D., Free PMC Article | 06/29/2013 |
| Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells. | Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.
Sdelci S, Schütz M, Pinyol R, Bertran MT, Regué L, Caelles C, Vernos I, Roig J. | 01/12/2013 |
| The interaction between the human NimA-like protein kinase Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance. | Recognition of host proteins by Helicobacter cysteine-rich protein C.
Roschitzki B, Schauer S, Mittl PR. | 11/26/2011 |
| Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. | Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
Bertran MT, Sdelci S, Regué L, Avruch J, Caelles C, Roig J., Free PMC Article | 09/17/2011 |
| DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. | DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.
Regué L, Sdelci S, Bertran MT, Caelles C, Reverter D, Roig J., Free PMC Article | 07/30/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ., Free PMC Article | 06/30/2010 |
| The activity of Nek6 and Nek7, but not the tyrosine mutant, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism in which the tyrosine is released from its autoinhibitory position. | An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.
Richards MW, O'Regan L, Mas-Droux C, Blot JM, Cheung J, Hoelder S, Fry AM, Bayliss R., Free PMC Article | 01/21/2010 |