| Identifying CD1c as a potential biomarker by the comprehensive exploration of tumor mutational burden and immune infiltration in diffuse large B cell lymphoma. | Identifying CD1c as a potential biomarker by the comprehensive exploration of tumor mutational burden and immune infiltration in diffuse large B cell lymphoma.
Xiang X, Gao LM, Zhang Y, Zhu Q, Zhao S, Liu W, Ye Y, Tang Y, Zhang W., Free PMC Article | 12/20/2023 |
| CD1C is associated with breast cancer prognosis and immune infiltrates. | CD1C is associated with breast cancer prognosis and immune infiltrates.
Chen X, Zhang J, Lei X, Yang L, Li W, Zheng L, Zhang S, Ding Y, Shi J, Zhang L, Li J, Tang T, Jia W., Free PMC Article | 02/13/2023 |
| Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. | Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells.
Reijneveld JF, Marino L, Cao TP, Cheng TY, Dam D, Shahine A, Witte MD, Filippov DV, Suliman S, van der Marel GA, Moody DB, Minnaard AJ, Rossjohn J, Codée JDC, Van Rhijn I., Free PMC Article | 11/27/2021 |
| Animal models for human group 1 CD1 protein function. | Animal models for human group 1 CD1 protein function.
Eckhardt E, Bastian M. | 03/6/2021 |
| The expression of histones, small nucleolar RNA H/ACA box (SNORA) and small nucleolar RNA C/D/box (SNORD), and long non-coding RNA (lncRNA) is also substantially upregulated in the DCs from aged. In contrast, the antigen-presenting and energy generating pathways are downregulated | Transcriptional Profiling of Age-Associated Gene Expression Changes in Human Circulatory CD1c+ Myeloid Dendritic Cell Subset.
Rahmatpanah F, Agrawal S, Scarfone VM, Kapadia S, Mercola D, Agrawal A., Free PMC Article | 11/2/2019 |
| these results demonstrated the mechanism that suppression of CD1c by BCG infection is mediated by miR-381-3p | MiR-381-3p Regulates the Antigen-Presenting Capability of Dendritic Cells and Represses Antituberculosis Cellular Immune Responses by Targeting CD1c.
Wen Q, Zhou C, Xiong W, Su J, He J, Zhang S, Du X, Liu S, Wang J, Ma L. | 08/12/2017 |
| We found a significant difference in the density of intraepidermal CD1c+ cells between the examined lesions; the mean CD1c cell count was 7.00/mm(2) for invasive melanomas, 2.94 for in situ melanomas, and 13.35 for dysplastic nevi | Melanomas and Dysplastic Nevi Differ in Epidermal CD1c+ Dendritic Cell Count.
Dyduch G, Tyrak KE, Glajcar A, Szpor J, Ulatowska-Białas M, Okoń K., Free PMC Article | 04/22/2017 |
| Stressed beta-cells have little effect on human BDCA1-expressed dendritic cells activation and function, while enterovirus-infected beta-cells impact these cells significantly. | Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected β cells.
Schulte BM, Kers-Rebel ED, Bottino R, Piganelli JD, Galama JM, Engelse MA, de Koning EJ, Adema GJ., Free PMC Article | 03/25/2017 |
| Circulating atopic dermatitis pre-dendritic CD1c+ cells are premature and bear atopic characteristics even without tissue-specific stimulation, suggesting that their development is not only influenced by the skin microenvironment, but also by the local milieu in the blood. | CD1c+ Blood Dendritic Cells in Atopic Dermatitis are Premature and Can Produce Disease-specific Chemokines.
Kapitány A, Béke G, Nagy G, Doan-Xuan QM, Bacso Z, Gáspár K, Boros G, Dajnoki Z, Bíró T, Rajnavölgyi É, Szegedi A. | 03/25/2017 |
| human CD1c adopts different conformations dependent on ligand occupancy of its groove, with CE and ASG stabilizing CD1c conformations that provide a footprint for binding of CD1c self-reactive T-cell receptors | Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.
Mansour S, Tocheva AS, Cave-Ayland C, Machelett MM, Sander B, Lissin NM, Molloy PE, Baird MS, Stübs G, Schröder NW, Schumann RR, Rademann J, Postle AD, Jakobsen BK, Marshall BG, Gosain R, Elkington PT, Elliott T, Skylaris CK, Essex JW, Tews I, Gadola SD., Free PMC Article | 08/6/2016 |
| There was a significant increase of blood CD1c(+) myeloid dendritic cells in autoimmune uveitis patients. The mature phenotype and function of CD1c(+) mDC1 were regulated by TNFalpha via a p38 MAPK-dependent pathway. | Increased CD1c+ mDC1 with mature phenotype regulated by TNFα-p38 MAPK in autoimmune ocular inflammatory disease.
Chen P, Denniston A, Hannes S, Tucker W, Wei L, Liu B, Xiao T, Hirani S, Li Z, Jawad S, Si H, Lee RW, Sen HN, Nussenblatt RB., Free PMC Article | 07/25/2015 |
| decidual CD1c(+) dendritic cells with Toxoplasma gondii infection have enhanced cytotoxicity of decidual natural killer cells | Toxoplasma gondii infection of decidual CD1c(+) dendritic cells enhances cytotoxicity of decidual natural killer cells.
Liu X, Zhao M, Yang X, Han M, Xu X, Jiang Y, Hu X. | 03/7/2015 |
| hMPV-infected BDCA-1(+) and BDCA-3(+) mDCs induced expansion of Th17 cells, in response to RSV, BDCA-1(+) mDCs induced expansion of Th1 cells and BDCA-3(+) mDCs induced expansion of Th2 cells and Tregs | Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells.
Gupta MR, Kolli D, Molteni C, Casola A, Garofalo RP., Free PMC Article | 02/7/2015 |
| mLPA-specific T cells efficiently kill CD1c(+) acute leukemia cells, poorly recognize nontransformed CD1c-expressing cells, and protect immunodeficient mice against CD1c(+) human leukemia cells. | A novel self-lipid antigen targets human T cells against CD1c(+) leukemias.
Lepore M, de Lalla C, Gundimeda SR, Gsellinger H, Consonni M, Garavaglia C, Sansano S, Piccolo F, Scelfo A, Häussinger D, Montagna D, Locatelli F, Bonini C, Bondanza A, Forcina A, Li Z, Ni G, Ciceri F, Jenö P, Xia C, Mori L, Dellabona P, Casorati G, De Libero G., Free PMC Article | 09/6/2014 |
| [review] Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in response to the presentation of endogenous lipids. | Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them.
Adams EJ., Free PMC Article | 08/16/2014 |
| Activated dendritic cell subsets expressing CD141/CLEA9A/CD1c, likely recruited into the tubulointerstitium, are positioned to play a role in the development of fibrosis and, thus, progression to chronic kidney disease. | Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease.
Kassianos AJ, Wang X, Sampangi S, Muczynski K, Healy H, Wilkinson R. | 01/18/2014 |
| CD1c+ myeloid dendritic cells were increased in idiopathic pulmonary fibrosis patients versus controls. | Increased bronchoalveolar lavage fluid CD1c expressing dendritic cells in idiopathic pulmonary fibrosis.
Tsoumakidou M, Karagiannis KP, Bouloukaki I, Zakynthinos S, Tzanakis N, Siafakas NM. | 01/11/2014 |
| RSV infection induces a distinct pattern of costimulatory molecule expression and cytokine production by BDCA-1(+) and BDCA-3(+) mDCs, and impairs their ability to stimulate T cell proliferation. | Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection.
Gupta MR, Kolli D, Garofalo RP., Free PMC Article | 10/19/2013 |
| for isoforms CD1b through CD1e, our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices. | Dynamics of the antigen-binding grooves in CD1 proteins: reversible hydrophobic collapse in the lipid-free state.
Garzón D, Anselmi C, Bond PJ, Faraldo-Gómez JD., Free PMC Article | 09/14/2013 |
| Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment. | Dysregulated CD1 profile in myeloid dendritic cells in CVID is normalized by IVIg treatment.
Paquin-Proulx D, Santos BA, Carvalho KI, Toledo-Barros M, Oliveira AK, Kokron CM, Kalil J, Moll M, Kallas EG, Sandberg JK., Free PMC Article | 08/31/2013 |
| Downregulation of both CD1c and CD1d expression through a Vpu-dependent and Nef-independent mechanism, and the concomitant HIV-1-induced production of host cholesterol decreased the extent of CD1c and CD1d modulation. | Effects of HIV-1-induced CD1c and CD1d modulation and endogenous lipid presentation on CD1c-restricted T-cell activation.
Kelly H, Mandraju R, Coelho-dos-Reis JG, Tsuji M., Free PMC Article | 07/6/2013 |
| Molecular mechanisms by which CD1c captures distinct classes of self- and mycobacterial antigens are reviewed. Review. | CD1a, CD1b, and CD1c in immunity against mycobacteria.
Van Rhijn I, Ly D, Moody DB. | 07/6/2013 |
| CD1c-PM complexes stain T cell receptors (TCRs), providing direct evidence for a ternary interaction among CD1c-lipid-TCR. | CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens.
Ly D, Kasmar AG, Cheng TY, de Jong A, Huang S, Roy S, Bhatt A, van Summeren RP, Altman JD, Jacobs WR Jr, Adams EJ, Minnaard AJ, Porcelli SA, Moody DB., Free PMC Article | 06/8/2013 |
| Data suggest that when CD1c is up-regulated, ILT4 is recruited to CD1c, thus reducing the inhibitory effect of immunoglobulin-like transcript 4 (ILT4) on CD1d recognition. | A novel role of CD1c in regulating CD1d-mediated NKT cell recognition by competitive binding to Ig-like transcript 4.
Li D, Hong A, Lu Q, Gao GF, Jin B, Screaton GR, Xu XN. | 04/13/2013 |
| Escherichia coli-activated CD1c(+) dendritic cells suppressed T-cell proliferation in an IL-10-dependent manner | Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.
Kassianos AJ, Hardy MY, Ju X, Vijayan D, Ding Y, Vulink AJ, McDonald KJ, Jongbloed SL, Wadley RB, Wells C, Hart DN, Radford KJ. | 08/18/2012 |