| Lack of ceramide synthase 5 protects retinal ganglion cells from ocular hypertensive injury. | Lack of ceramide synthase 5 protects retinal ganglion cells from ocular hypertensive injury.
Liu J, Koutalos Y, Fan J., | 09/19/2024 |
| Identification of CERS5 as a molecular biomarker in pan-cancer through multiple omics integrative analysis. | Identification of CERS5 as a molecular biomarker in pan-cancer through multiple omics integrative analysis.
Wang S, Yang J, Huang W, Yu Z, Mao Y, Feng Y, Chen J. | 03/4/2024 |
| in p53(wt) colon cancer cells chemosensitivity against oxaliplatin or 5-fluorouracil could be enhanced by downregulation of CerS5 expression leading to reduced autophagy and mitochondrial respiration. | Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.
Brachtendorf S, Wanger RA, Birod K, Thomas D, Trautmann S, Wegner MS, Fuhrmann DC, Brüne B, Geisslinger G, Grösch S. | 06/8/2019 |
| LASS5 interacts with SDHB and synergistically represses p53 and p21 activity. | LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity.
Jiang Z, Li F, Wan Y, Han Z, Yuan W, Cao L, Deng Y, Peng X, Chen F, Fan X, Liu X, Dai G, Wang Y, Zeng Q, Shi Y, Zhou Z, Chen Y, Xu W, Luo S, Chen S, Ye X, Mo X, Wu X, Li Y., Free PMC Article | 10/7/2017 |
| Studied the role of ceramide synthase 5 (LASS5 or CERS5) gene in atherosclerosis. Downregulation of LASS5 by siRNA was found to attenuate ceramide production and increase expression of some AMPK target genes in HUVEC. Found that LASS5 was involved in negative regulation of atherosclerosis-related genes, such as AMPK-alpha. | [Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].
Çoban N, Güçlü Geyik F, Yıldırım Ö, Erginel Ünaltuna N. | 09/9/2017 |
| These results suggest that the phosphorylation of ceramide synthases may be a key regulatory point in the control of the distribution and levels of sphingolipids of various acyl-chain lengths. | Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.
Sassa T, Hirayama T, Kihara A., Free PMC Article | 08/20/2016 |
| mRNA level of CerS5 is higher in cancerous cell lines and decreases following the induction of apoptosis. | Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.
Mojakgomo R, Mbita Z, Dlamini Z. | 08/1/2015 |
| Overexpression of CerS5 increased apoptosis in HeLa cells. | Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R., Free PMC Article | 07/19/2010 |
| Down-regulation of either acid sphingomyelinase or LASS 5-attenuated ceramide accumulation and H/R-induced Bax translocation to mitochondria. | Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells.
Jin J, Hou Q, Mullen TD, Zeidan YH, Bielawski J, Kraveka JM, Bielawska A, Obeid LM, Hannun YA, Hsu YT., Free PMC Article | 01/21/2010 |
| accumulation of C(16)-ceramide in mitochondria formed from the protein kinase C-dependent salvage pathway results at least in part from the action of longevity-assurance homologue 5, and the generated ceramide modulates the p38 cascade via PP1 | Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. | 01/21/2010 |
| study identifies LASS5 as a genuine dihydroceramide synthase and demonstrates that mammalian dihydroceramide synthases do not require additional subunits for their activity | LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.
Lahiri S, Futerman AH. | 01/21/2010 |