| The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation. | The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation.
Shimizu T, Nakamura T, Inaba H, Iwasa H, Maruyama J, Arimoto-Matsuzaki K, Nakata T, Nishina H, Hata Y., Free PMC Article | 02/20/2021 |
| UNC119 was significantly upregulated and promoted cell growth in hepatic cancer cells and tissues by the Wnt/beta-catenin signal pathway and migration by TGF-beta/EMT signal pathway. Curcumin treatment inhibited cell proliferation, growth, migration, and invasion by inhibition of those pathways. | Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression.
Zhao Z, Malhotra A, Seng WY. | 11/9/2019 |
| UNC119 was significantly up-regulated in liver cancer cells and tissues. It promoted cell growth and migration through the Wnt/beta-catenin and TGF-beta/EMT signaling pathways, respectively. | UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β/catenin and TGF/β-EMT signaling pathways.
Liu Z, Zhang Y, Xu Z. | 09/28/2019 |
| UNC119 is significantly up-regulated and promoted cell growth and migration in hepatic cancer cells and tissues via Wnt/b-catenin signal pathway and TGF-b/EMT signal pathway | UNC119 promoted cell growth and migration by Wnt/β-catenin signal and TGF-β/EMT signal pathway in hepatocellular carcinoma.
Liu ZH, Zhang YF, Xu ZD, Z H L, Y F Z, Z D X. | 08/31/2019 |
| UNC119 was significantly up-regulated in liver cancer cells and tissues. It promoted cell growth and migration through the Wnt/beta-catenin and TGF-beta/EMT signaling pathways, respectively | UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β-catenin and TGF-β/EMT signaling pathways.
Liu Z, Zhang Y, Xu Z. | 02/2/2019 |
| The findings support that UNC119 is a regulator of the RASSF6-MDM2-p53 axis and functions as a tumor suppressor. | UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53.
Iwasa H, Sarkar A, Shimizu T, Sawada T, Hossain S, Xu X, Maruyama J, Arimoto-Matsuzaki K, Withanage K, Nakagawa K, Kurihara H, Kuroyanagi H, Hata Y., Free PMC Article | 10/20/2018 |
| This review will outline the trafficking pathways required for constructing the cilium by highlighting UNC119's role and the complexities involved in ciliary trafficking. Finally, despite important roles for UNC119 in cilia, UNC119 proteins also interact with non-ciliary proteins to affect other cellular processes. | Coordinating the uncoordinated: UNC119 trafficking in cilia.
Jean F, Pilgrim D. | 06/9/2018 |
| Data show that the solubilising factor UNC119 sequesters myristoylated Src family protein tyrosine kinases (SFKs) to maintain its enrichment at the plasma membrane to enable signal transduction. | Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation.
Konitsiotis AD, Roßmannek L, Stanoev A, Schmick M, Bastiaens PIH., Free PMC Article | 11/18/2017 |
| Studies indicate that the binding of UNC119 and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner. | Shuttling and sorting lipid-modified cargo into the cilia.
Stephen LA, Ismail S. | 07/15/2017 |
| Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3. | Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.
Jaiswal M, Fansa EK, Kösling SK, Mejuch T, Waldmann H, Wittinghofer A., Free PMC Article | 05/20/2017 |
| UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis. | UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.
Lee Y, Chung S, Baek IK, Lee TH, Paik SY, Lee J., Free PMC Article | 11/16/2013 |
| The profile of UNC119a subcellular distribution remained largely unchanged under all tested conditions of illumination, and correlated with the profile of Galpha(t1) following its light-dependent translocation. | Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors.
Sinha S, Majumder A, Belcastro M, Sokolov M, Artemyev NO., Free PMC Article | 05/4/2013 |
| The discovery of the UNC119 defect provides a molecular mechanism for a subset of patients with this previously unexplained disease. Here we review our recent findings on the UNC119 mutation in ICL. | Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.
Gorska MM, Alam R. | 03/30/2013 |
| Crystal structures of Arl3 in complex with UNC119a reveal the molecular basis of specificity. The N-terminal amphipathic helix of Arl3.GppNHp is not displaced by the interswitch toggle but remains bound on the surface of the protein | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Ismail SA, Chen YX, Miertzschke M, Vetter IR, Koerner C, Wittinghofer A., Free PMC Article | 01/26/2013 |
| Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors. | Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.
Gopalakrishna KN, Doddapuneni K, Boyd KK, Masuho I, Martemyanov KA, Artemyev NO., Free PMC Article | 10/22/2011 |
| This study demonistrated that UNC119 is a Galpha subunit cofactor essential for G protein trafficking in sensory cilia. | UNC119 is required for G protein trafficking in sensory neurons.
Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W., Free PMC Article | 09/3/2011 |
| Observational study of genetic testing. (HuGE Navigator) | Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.
Booij JC, Bakker A, Kulumbetova J, Moutaoukil Y, Smeets B, Verheij J, Kroes HY, Klaver CC, van Schooneveld M, Bergen AA, Florijn RJ. | 12/5/2010 |
| Heightened expression of Unc119 promotes T helper type (Th)2 cells, inhibits Th1 cell differentiation, and contributes to the pathogenesis of asthma in humans. | Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma.
Gorska MM, Goplen N, Liang Q, Alam R. | 05/31/2010 |
| demonstrate a role for Unc119 in clathrin- and caveolae-based endocytosis as well as macropinocytosis. Depletion of Unc119 in fibroblasts increases FM4-64, albumin, viruses, and ligand-coated beads. | UNC119 inhibits dynamin and dynamin-dependent endocytic processes.
Karim Z, Vepachedu R, Gorska M, Alam R. | 01/21/2010 |
| Unc119 orchestrates the recruitment of the actin-based motor protein, myosin 5B, and the organization of multiprotein complexes on endosomes. The Unc119-regulated pathway is essential for immunological synapse formation and T cell activation. | Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.
Gorska MM, Liang Q, Karim Z, Alam R. | 01/21/2010 |
| identification as activator of SRC-type tyrosine kinases | Identification of UNC119 as a novel activator of SRC-type tyrosine kinases.
Cen O, Gorska MM, Stafford SJ, Sur S, Alam R. | 01/21/2010 |
| The presence of ARL2 in the retina and co-localization with HRG4 was confirmed. Amino acid residues of PDEdelta involved in binding ARL2 and forming a hydrophobic pocket were shown to be highly conserved in HRG4 | Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain.
Kobayashi A, Kubota S, Mori N, McLaren MJ, Inana G. | 01/21/2010 |
| Unc119 plays an important role in fibrotic processes through myofibroblast differentiation; Unc119 increases the kinase activity of Fyn and associates with it in coprecipitation and colocalization studies. | Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway.
Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R. | 01/21/2010 |