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    CD1A CD1a molecule [ Homo sapiens (human) ]

    Gene ID: 909, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CD1 molecules: Beyond antigen presentation.

    CD1 molecules: Beyond antigen presentation.
    Evans L, Barral P., Free PMC Article

    06/10/2024
    CD1a and skin T cells: a pathway for therapeutic intervention.

    CD1a and skin T cells: a pathway for therapeutic intervention.
    Ye JH, Chen YL, Ogg G., Free PMC Article

    05/9/2024
    Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells.

    Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells.
    Marques ERMDC, Hsieh R, Lourenço SV, Nico MMS.

    04/15/2024
    Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency.

    Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency.
    Kobiela A, Hewelt-Belka W, Frąckowiak JE, Kordulewska N, Hovhannisyan L, Bogucka A, Etherington R, Piróg A, Dapic I, Gabrielsson S, Brown SJ, Ogg GS, Gutowska-Owsiak D., Free PMC Article

    04/12/2024
    Human Skin T Cells Express Conserved T-Cell Receptors that Cross-React with Staphylococcal Superantigens and CD1a.

    Human Skin T Cells Express Conserved T-Cell Receptors that Cross-React with Staphylococcal Superantigens and CD1a.
    Bryan E, Teague JE, Eligul S, Arkins WC, Moody DB, Clark RA, Van Rhijn I.

    03/27/2024
    CD1a is not effective in distinguishing calcifying epithelial odontogenic tumors from amyloid-rich central odontogenic fibroma.

    CD1a is not effective in distinguishing calcifying epithelial odontogenic tumors from amyloid-rich central odontogenic fibroma.
    Bruett CT, Roark S, Reich RF, Freedman PD.

    01/3/2024
    CD1a and bound lipids drive T-cell responses in human skin disease.

    CD1a and bound lipids drive T-cell responses in human skin disease.
    Ogg GS, Rossjohn J, Clark RA, Moody DB., Free PMC Article

    10/24/2023
    CD1a-mediated immunity from a molecular perspective.

    CD1a-mediated immunity from a molecular perspective.
    Wegrecki M.

    06/1/2023
    Human skin is colonized by T cells that recognize CD1a independently of lipid.

    Human skin is colonized by T cells that recognize CD1a independently of lipid.
    Cotton RN, Cheng TY, Wegrecki M, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis RA, Altman JD, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark RA, Moody DB., Free PMC Article

    09/11/2021
    Animal models for human group 1 CD1 protein function.

    Animal models for human group 1 CD1 protein function.
    Eckhardt E, Bastian M.

    03/6/2021
    CD1a function in human skin disease.

    CD1a function in human skin disease.
    de Jong A, Ogg G., Free PMC Article

    03/6/2021
    rs16840041, rs2269714, and rs2269715 in high linkage disequilibrium and significantly associated with increase in plasma NFL levels

    Genome-wide association study identifies CD1A associated with rate of increase in plasma neurofilament light in non-demented elders.
    Wang ZT, Chen SD, Xu W, Chen KL, Wang HF, Tan CC, Cui M, Dong Q, Tan L, Yu JT, Alzheimer’s Disease Neuroimaging Initiative., Free PMC Article

    07/25/2020
    No statistically significant differences were found between groups of patients studied according to Guillain-Barre Syndrome diagnosis and other covariates ana-lyzed: sex, age, genotypes CD1A.

    Guillain-Barre syndrome outbreak in Peru: Association with polymorphisms in IL-17, ICAM1, and CD1.
    Jaramillo-Valverde L, Levano KS, Villanueva I, Hidalgo M, Cornejo M, Mazzetti P, Cornejo-Olivas M, Sanchez C, Poterico JA, Valdivia-Silva J, Guio H., Free PMC Article

    06/27/2020
    Single nucleotide polymorphisms in exon 2 of CD1A (*01/*02) and CD1E (*01/*02) cannot be recognized as a susceptibility or disease-causative factor for Guillain-Barre syndrome in the Bangladeshi population

    CD1A and CD1E gene polymorphisms are not associated with susceptibility to Guillain-Barré syndrome in the Bangladeshi population.
    Rahman MI, Jahan I, Khalid MM, Jahan I, Ahammad RU, Nahar S, Islam Z.

    07/6/2019
    CD1 antigen presenting molecules are nonpolymorphic and specialized for lipid antigen presentation to T cells [Review].

    Potential advantages of CD1-restricted T cell immunotherapy in cancer.
    Consonni M, Dellabona P, Casorati G.

    05/4/2019
    CD1a expression is up-regulated by TSLP (thymic stromal lymphopoietin) at levels observed in the skin of patients with atopic dermatitis, and the response is dependent on PLA2G4A.

    CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.
    Hardman CS, Chen YL, Salimi M, Jarrett R, Johnson D, Järvinen VJ, Owens RJ, Repapi E, Cousins DJ, Barlow JL, McKenzie ANJ, Ogg G., Free PMC Article

    11/3/2018
    In this review, authors summarize the current knowledge about CD1 proteins, their structures, lipid-binding profiles, and roles in immunity, and evaluate the role of CD1 proteins in eliciting humoral immune response

    CD1: A Singed Cat of the Three Antigen Presentation Systems.
    Kaczmarek R, Pasciak M, Szymczak-Kulus K, Czerwinski M., Free PMC Article

    02/24/2018
    CD207(+)CD1a(+) cells are circulating in patients with active Langerhans cell histiocytosis, and TSLP and TGF-beta are potential drivers of Langerhans-like cells in vivo.

    CD207(+)CD1a(+) cells circulate in pediatric patients with active Langerhans cell histiocytosis.
    Carrera Silva EA, Nowak W, Tessone L, Olexen CM, Ortiz Wilczyñski JM, Estecho IG, Elena G, Errasti AE, Rosso DA.

    11/11/2017
    CD1a+ CD11b+ macrophages and NK T-cells were found to be significantly increased in inflamed colons of ulcerative colitis patients.

    Immunological profiling of patients with ulcerative colitis leads to identification of two inflammatory conditions and CD1a as a disease marker.
    Föhlinger M, Palamides P, Mansmann U, Beigel F, Siebeck M, Gropp R., Free PMC Article

    10/21/2017
    The findings suggest that PLA2 inhibition or CD1a blockade may have therapeutic potential for psoriasis.

    Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.
    Cheung KL, Jarrett R, Subramaniam S, Salimi M, Gutowska-Owsiak D, Chen YL, Hardman C, Xue L, Cerundolo V, Ogg G., Free PMC Article

    08/5/2017
    these observations suggest that CD99 is involved in the regulation of CD1a transcription and expression by increasing ATF-2.

    CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2/CREB-1 phosphorylation.
    Mahiddine K, Mallavialle A, Bziouech H, Larbret F, Bernard A, Bernard G.

    07/1/2017
    this study shows that CD1a drove the pathogenesis of poison-ivy dermatitis and psoriasis, and that CD1a-mediated skin inflammation was abrogated by CD1a-blocking antibodies, which highlights CD1a as a target for treatment of inflammatory skin diseases

    CD1a on Langerhans cells controls inflammatory skin disease.
    Kim JH, Hu Y, Yongqing T, Kim J, Hughes VA, Le Nours J, Marquez EA, Purcell AW, Wan Q, Sugita M, Rossjohn J, Winau F., Free PMC Article

    06/3/2017
    The data show that immunohistochemistry for CD1a and Hsp60 can be of help in differential diagnosis between Keratoacantomas and well-differentiated forms of squamous cell carcinomas.

    CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.
    Cabibi D, Conway de Macario E, Ingrao S, Porcasi R, Zucco F, Macario AJL, Cappello F, Rappa F., Free PMC Article

    10/1/2016
    NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas

    NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas.
    Virani S, Bellile E, Bradford CR, Carey TE, Chepeha DB, Colacino JA, Helman JI, McHugh JB, Peterson LA, Sartor MA, Taylor JM, Walline HM, Wolf GT, Rozek LS., Free PMC Article

    08/20/2016
    Findings suggest that dermal survivin+CD1a+ (CD1a antigen) cell infiltration may be a potential biomarker of systemic sclerosis skin lesions.

    CD1a+ survivin+ dendritic cell infiltration in dermal lesions of systemic sclerosis.
    Mokuda S, Miyazaki T, Ubara Y, Kanno M, Sugiyama E, Takasugi K, Masumoto J., Free PMC Article

    07/16/2016
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