| SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation. | SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation.
Zhang M, Yang F, Wang W, Zohbi N, Wang X, Wang D, Zhuang X, Dou Z, Liu D, Song X, Green HN, Liu X, Yao X., Free PMC Article | 05/14/2022 |
| Phosphorylation of small kinetochore-associated protein induced by GSK3beta promotes cell migration and invasion in esophageal cancer. | Phosphorylation of small kinetochore-associated protein induced by GSK3β promotes cell migration and invasion in esophageal cancer.
Qin B, Zhu Z, Yin F, Yan D, Wan J, Dong M, Wang Z., Free PMC Article | 04/30/2022 |
| Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle. | Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle.
Morii M, Kubota S, Hasegawa C, Takeda Y, Kometani S, Enomoto K, Suzuki T, Yanase S, Sato R, Akatsu A, Hirata K, Honda T, Kuga T, Tomonaga T, Nakayama Y, Yamaguchi N, Yamaguchi N., Free PMC Article | 10/2/2021 |
| KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer. | KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer.
Xiong Y, Ju L, Yuan L, Chen L, Wang G, Xu H, Peng T, Luo Y, Xiao Y, Wang X. | 07/31/2021 |
| Recurrent somatic mutation p.Ala40Glu in KNSTRN gene is associated with basal proliferating actinic keratosis in accordance with invasive squamous cell cardinomas. This supports the impact of basal proliferative pattern in terms of progression | Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.
Schmitz L, Grinblat B, Novak B, Hoeh AK, Händschke K, von Dobbeler C, Bierhoff E, Szeimies RM, Gambichler T, Torezan L, Festa-Neto C, Stockfleth E, Dirschka T. | 02/22/2020 |
| The authors show that the Astrin-SKAP complex binds synergistically to microtubules with the Ndc80 complex to form an integrated interface. | Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80.
Kern DM, Monda JK, Su KC, Wilson-Kubalek EM, Cheeseman IM., Free PMC Article | 06/16/2018 |
| GSK3beta-SKAP-Kif2b signaling axis constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. | Phosphorylation of SKAP by GSK3β ensures chromosome segregation by a temporal inhibition of Kif2b activity.
Qin B, Cao D, Wu H, Mo F, Shao H, Chu J, Powell M, Aikhionbare F, Wang D, Fu C, He P, Pan W, Wang W, Liu X, Yao X., Free PMC Article | 06/16/2018 |
| Data show that aurora-B regulates end-on conversion in human cells and indicate a late role for SPAG5 protein (Astrin)-SKAP complex in the end-on conversion process. | Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.
Shrestha RL, Conti D, Tamura N, Braun D, Ramalingam RA, Cieslinski K, Ries J, Draviam VM., Free PMC Article | 11/18/2017 |
| KNSTRN Mutation, a Cutaneous Squamous Carcinoma-Specific Mutation is associated with Solid Tumors and Leukemias. | Absence of KNSTRN Mutation, a Cutaneous Squamous Carcinoma-Specific Mutation, in Other Solid Tumors and Leukemias.
Lee JH, Kim MS, Yoo NJ, Lee SH. | 10/22/2016 |
| Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin have been reported. | Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin.
Friese A, Faesen AC, Huis in 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A, Raunser S, Herzog F, Musacchio A., Free PMC Article | 09/10/2016 |
| study reports presence of KNSTRN mutations in basal cell carcinomas (BCC); mutant KNSTRN disrupts sister chromatid cohesion and promotes genomic instability in functional assays; KNSTRN mutations in BCC appear to occur late in disease progression and are preferentially found in advanced tumors | Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma.
Jaju PD, Nguyen CB, Mah AM, Atwood SX, Li J, Zia A, Chang ALS, Oro AE, Tang JY, Lee CS, Sarin KY., Free PMC Article | 05/14/2016 |
| Mechanistically, the N-terminal of SKAP binds to EB1, and its C terminus binds to IQGAP1 in migrating cells. | Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.
Cao D, Su Z, Wang W, Wu H, Liu X, Akram S, Qin B, Zhou J, Zhuang X, Adams G, Jin C, Wang X, Liu L, Hill DL, Wang D, Ding X, Yao X., Free PMC Article | 12/19/2015 |
| These findings suggest that SKAP promotes ultraviolet rays-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19. | Small kinetochore associated protein (SKAP) promotes UV-induced cell apoptosis through negatively regulating pre-mRNA processing factor 19 (Prp19).
Lu S, Wang R, Cai C, Liang J, Xu L, Miao S, Wang L, Song W., Free PMC Article | 01/10/2015 |
| Findings suggest a role for kinetochore protein KNSTRN mutagenesis in cutaneous squamous cell carcinomas (SCCs) development. | Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma.
Lee CS, Bhaduri A, Mah A, Johnson WL, Ungewickell A, Aros CJ, Nguyen CB, Rios EJ, Siprashvili Z, Straight A, Kim J, Aasi SZ, Khavari PA., Free PMC Article | 12/20/2014 |
| SKAP constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division. | Mitotic regulator SKAP forms a link between kinetochore core complex KMN and dynamic spindle microtubules.
Wang X, Zhuang X, Cao D, Chu Y, Yao P, Liu W, Liu L, Adams G, Fang G, Dou Z, Ding X, Huang Y, Wang D, Yao X., Free PMC Article | 02/23/2013 |
| SKAP cooperates with CENP-E to orchestrate dynamic kinetochore-microtubule interaction for faithful chromosome segregation. | CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis.
Huang Y, Wang W, Yao P, Wang X, Liu X, Zhuang X, Yan F, Zhou J, Du J, Ward T, Zou H, Zhang J, Fang G, Ding X, Dou Z, Yao X., Free PMC Article | 03/3/2012 |
| This paper identifies role of gene product of FLJ14502, named SKAP in the paper, in mitosis. SKAP promotes metaphase-to-anaphase transition by mediating seperase activation after spindle assembly checkpoint is satisfied in mitosis. | SKAP associates with kinetochores and promotes the metaphase-to-anaphase transition.
Fang L, Seki A, Fang G. | 02/18/2011 |