| Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer. | Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.
Salvati A, Melone V, Sellitto A, Rizzo F, Tarallo R, Nyman TA, Giurato G, Nassa G, Weisz A., Free PMC Article | 07/30/2022 |
| Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway. | Downregulation of Williams syndrome transcription factor (WSTF) suppresses glioblastoma cell growth and invasion by inhibiting PI3K/AKT signal pathway.
Yang L, Du C, Chen H, Diao Z., Free PMC Article | 03/26/2022 |
| Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population. | Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.
Kawaguchi M, Nakayama A, Aoyagi Y, Nakamura T, Shimizu S, Kawamura Y, Takao M, Tamura T, Hishida A, Nagayoshi M, Nagase M, Ooyama K, Ooyama H, Shinomiya N, Matsuo H., Free PMC Article | 08/7/2021 |
| Williams syndrome transcription factor promotes proliferation and invasion of cervical cancer cells by regulating PI3K/Akt signaling pathway. | Williams syndrome transcription factor promotes proliferation and invasion of cervical cancer cells by regulating PI3K/Akt signaling pathway.
Jiang D, Ren C, Yang L, Li F, Yang X, Zheng Y, Ji X, Tian Y. | 07/10/2021 |
| The mutational burden and oligogenic inheritance in Klippel-Feil syndrome. | The mutational burden and oligogenic inheritance in Klippel-Feil syndrome.
Li Z, Zhao S, Cai S, Zhang Y, Wang L, Niu Y, Li X, Hu J, Chen J, Wang S, Wang H, Liu G, Tian Y, Wu Z, Zhang TJ, DISCO (Deciphering Disorders Involving Scoliosis and COmorbidities) study, Wang Y, Wu N., Free PMC Article | 01/9/2021 |
| BAZ1B is a candidate gene responsible for hypothyroidism in Williams syndrome. | BAZ1B is a candidate gene responsible for hypothyroidism in Williams syndrome.
Allegri L, Baldan F, Mio C, De Felice M, Amendola E, Damante G. | 01/2/2021 |
| WSTF acetylation by MOF promotes WSTF activities and oncogenic functions. | WSTF acetylation by MOF promotes WSTF activities and oncogenic functions.
Liu Y, Zhang YY, Wang SQ, Li M, Long YH, Li YF, Liu YK, Li YH, Wang YQ, Mi JS, Yu CH, Li DY, Zhang JH, Zhang XJ. | 11/28/2020 |
| a modern-specific enrichment for regulatory changes both in BAZ1B and its experimentally defined downstream targets, is reported. | Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication.
Zanella M, Vitriolo A, Andirko A, Martins PT, Sturm S, O'Rourke T, Laugsch M, Malerba N, Skaros A, Trattaro S, Germain PL, Mihailovic M, Merla G, Rada-Iglesias A, Boeckx C, Testa G., Free PMC Article | 05/9/2020 |
| Authors propose that the WSTF-H2AX-RNAPII axis regulates transcription and transcription-coupled homologous recombination repair to maintain genome integrity. | De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.
Ji JH, Min S, Chae S, Ha GH, Kim Y, Park YJ, Lee CW, Cho H., Free PMC Article | 02/29/2020 |
| Study revealed a novel component of the chromosome scaffold, BAZ1B, which was localized to the mitotic chromosome axis. Using BAZ1A/B double- knockout cells, results suggest that BAZ1 proteins are essential for timely chromosome condensation at mitosis entry. | Quantitative Proteomics of the Mitotic Chromosome Scaffold Reveals the Association of BAZ1B with Chromosomal Axes.
Ohta S, Taniguchi T, Sato N, Hamada M, Taniguchi H, Rappsilber J., Free PMC Article | 11/30/2019 |
| The major conclusions of this study are that WSTF acts as an activator of ER signaling in MCF-7 breast cancer cells, that this action can be inhibited by 1alpha,25-dihydroxyvitamin D3, and that the expression of WSTF is higher in breast cancer tissue than in normal tissue. WSTF may by a new target for treatment of estrogen-dependent breast cancer cell growth. | Williams syndrome transcription factor (WSTF) acts as an activator of estrogen receptor signaling in breast cancer cells and the effect can be abrogated by 1α,25-dihydroxyvitamin D(3).
Lundqvist J, Kirkegaard T, Laenkholm AV, Duun-Henriksen AK, Bak M, Feldman D, Lykkesfeldt AE. | 03/16/2019 |
| promotes recovery after DNA damage, in part by recruiting SMARCA5 to damaged chromatin | Non-canonical reader modules of BAZ1A promote recovery from DNA damage.
Oppikofer M, Sagolla M, Haley B, Zhang HM, Kummerfeld SK, Sudhamsu J, Flynn EM, Bai T, Zhang J, Ciferri C, Cochran AG., Free PMC Article | 02/10/2018 |
| Data show that Williams-Beuren syndrome transcription factor (WSTF) release was mediated by neuregulin-3 (NRG3) following KRASG12V expression in intestinal epithelial cells. | KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway.
Liu Y, Wang SQ, Long YH, Chen S, Li YF, Zhang JH., Free PMC Article | 02/3/2018 |
| WSTF may act as an oncoprotein in lung cancer to accelerate tumor aggressiveness. | WSTF promotes proliferation and invasion of lung cancer cells by inducing EMT via PI3K/Akt and IL-6/STAT3 signaling pathways.
Meng J, Zhang XT, Liu XL, Fan L, Li C, Sun Y, Liang XH, Wang JB, Mei QB, Zhang F, Zhang T. | 12/2/2017 |
| A pivotal role for BAZ1B in neurodevelopment was revealed and its haploinsufficiency was implicated as a likely contributor to the neurological phenotypes in Williams syndrome through transcriptional dysregulation. | Haploinsufficiency of BAZ1B contributes to Williams syndrome through transcriptional dysregulation of neurodevelopmental pathways.
Lalli MA, Jang J, Park JH, Wang Y, Guzman E, Zhou H, Audouard M, Bridges D, Tovar KR, Papuc SM, Tutulan-Cunita AC, Huang Y, Budisteanu M, Arghir A, Kosik KS. | 01/28/2017 |
| Data indicate that the heterochromatic H2A.X is preferentially phosphorylated presumably by the accumulating WSTF-ISWI chromatin remodeling (WICH) complex, and suggests that Tyr142p might have a specific role in heterochromatin. | The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components.
Soldi M, Bonaldi T., Free PMC Article | 08/31/2013 |
| EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter. | Vitamin D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase.
Lundqvist J, Hansen SK, Lykkesfeldt AE. | 03/9/2013 |
| This review describes the three known WSTF-containing complexes and discuss their various roles as well as mechanisms of regulating WSTF activity. | WSTF does it all: a multifunctional protein in transcription, repair, and replication.
Barnett C, Krebs JE., Free PMC Article | 04/23/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesReplication of recently described type 2 diabetes gene variants in a South Indian population.
Chidambaram M, Radha V, Mohan V. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
Hegele RA, Ban MR, Hsueh N, Kennedy BA, Cao H, Zou GY, Anand S, Yusuf S, Huff MW, Wang J. | 09/16/2009 |
| A multiprotein complex containing WSTF, nuclear myosin 1 (NM1), and SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily A member 5 protein(SNF2h) is required for ribosomal DNA transcription. | The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.
Percipalle P, Fomproix N, Cavellán E, Voit R, Reimer G, Krüger T, Thyberg J, Scheer U, Grummt I, Farrants AK., Free PMC Article | 01/21/2010 |
| WSTF phosphorylates Tyr 142 of H2A.X, and WSTF activity has an important role in regulating several events that are critical for the DNA damage response | WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD., Free PMC Article | 01/21/2010 |
| WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling | The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.
Cavellán E, Asp P, Percipalle P, Farrants AK. | 01/21/2010 |