| RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells. | RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of the CMG helicase with DNA damage response in human cells.
Sun Q, Sui Y, Li S, Zhou R, Fu Z, Luo J, Zhao W. | 09/25/2024 |
| CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. | CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.
Chuah YH, Tay EXY, Grinchuk OV, Yoon J, Feng J, Kannan S, Robert M, Jakhar R, Liang Y, Lee BWL, Wang LC, Lim YT, Zhao T, Sobota RM, Lu G, Low BC, Crasta KC, Verma CS, Lin Z, Ong DST., Free PMC Article | 08/10/2023 |
| RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity. | RNF8 depletion attenuates hepatocellular carcinoma progression by inhibiting epithelial-mesenchymal transition and enhancing drug sensitivity.
Kuang J, Duan T, Gao C, Liu C, Chen S, Zhu LY, Min L, Lu C, Wang W, Zhu L., Free PMC Article | 05/17/2023 |
| RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression. | RNF8 up-regulates AR/ARV7 action to contribute to advanced prostate cancer progression.
Zhou T, Wang S, Song X, Liu W, Dong F, Huo Y, Zou R, Wang C, Zhang S, Liu W, Sun G, Lin L, Zeng K, Dong X, Guo Q, Yi F, Wang Z, Li X, Jiang B, Cao L, Zhao Y., Free PMC Article | 05/7/2022 |
| RNF8 induces beta-catenin-mediated c-Myc expression and promotes colon cancer proliferation. | RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation.
Ren L, Zhou T, Wang Y, Wu Y, Xu H, Liu J, Dong X, Yi F, Guo Q, Wang Z, Li X, Bai N, Guo W, Guo M, Jiang B, Wu X, Feng Y, Song X, Zhang S, Zhao Y, Cao L, Han S, Xing C., Free PMC Article | 11/13/2021 |
| RNF8 Promotes Epithelial-Mesenchymal Transition in Lung Cancer Cells via Stabilization of Slug. | RNF8 Promotes Epithelial-Mesenchymal Transition in Lung Cancer Cells via Stabilization of Slug.
Kuang J, Min L, Liu C, Chen S, Gao C, Ma J, Wu X, Li W, Wu L, Zhu L. | 09/18/2021 |
| RNF8-ubiquitinated KMT5A is required for RNF168-induced H2A ubiquitination in response to DNA damage. | RNF8-ubiquitinated KMT5A is required for RNF168-induced H2A ubiquitination in response to DNA damage.
Lu X, Xu M, Zhu Q, Zhang J, Liu G, Bao Y, Gu L, Tian Y, Wen H, Zhu WG. | 07/24/2021 |
| The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple-negative breast cancer cells. | The ubiquitin ligase RNF8 regulates Rho GTPases and promotes cytoskeletal changes and motility in triple-negative breast cancer cells.
Pereira De Carvalho B, Chern YJ, He J, Chan CH., Free PMC Article | 07/17/2021 |
| RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells. | RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells.
Nakajima NI, Yamauchi M, Kakoti S, Cuihua L, Kato R, Permata TBM, Iijima M, Yajima H, Yasuhara T, Yamada S, Hasegawa S, Shibata A. | 03/13/2021 |
| RNF8 has both KU-dependent and independent roles in chromosomal break repair. | RNF8 has both KU-dependent and independent roles in chromosomal break repair.
Tsai LJ, Lopezcolorado FW, Bhargava R, Mendez-Dorantes C, Jahanshir E, Stark JM., Free PMC Article | 09/12/2020 |
| during HTLV-1 infection, Tax activates RNF8 to assemble nuclear K63-pUbs that sequester DDR factors in Tax speckles, disrupting DDR signaling and DSB repair. | RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia.
Zhi H, Guo X, Ho YK, Pasupala N, Engstrom HAA, Semmes OJ, Giam CZ., Free PMC Article | 07/25/2020 |
| These findings suggested that RNF8 promotes efficient DNA double-strand break repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60. | RNF8 promotes efficient DSB repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60.
Chen H, Shan J, Liu J, Feng Y, Ke Y, Qi W, Liu W, Zeng X., Free PMC Article | 04/18/2020 |
| the miR-214-RNF8 axis has a role in epithelial-mesenchymal transition in breast cancer; miR-214 acts as a tumor suppressor | miR-214 inhibits epithelial-mesenchymal transition of breast cancer cells via downregulation of RNF8.
Min L, Liu C, Kuang J, Wu X, Zhu L. | 02/15/2020 |
| UV-induced NONO degradation by RNF8 is required for timely termination of intra-S-phase checkpoint signaling and continued cell cycle progression. | RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling.
Deshar R, Yoo W, Cho EB, Kim S, Yoon JB., Free PMC Article | 08/24/2019 |
| data are in line with a model in which HUWE1 primes histone H1 with ubiquitin to allow ubiquitin chain elongation by RNF8, thereby stimulating the RNF8-RNF168 mediated DDR. | DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.
Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA., Free PMC Article | 07/6/2019 |
| L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage, regulating the DNA damage response pathway. | L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage.
Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z., Free PMC Article | 04/20/2019 |
| study describes RNF8 as a co-activator of ERalpha increases ERalpha stability via post-transcriptional pathway, and provides a new insight into mechanisms for RNF8 to promote cell growth of ERalpha-positive breast cancer. | RNF8 identified as a co-activator of estrogen receptor α promotes cell growth in breast cancer.
Wang S, Luo H, Wang C, Sun H, Sun G, Sun N, Zeng K, Song H, Zou R, Zhou T, Cong R, Liu W, Yang L, Li D, Zhou X, Zhong X, Lin L, Jiao J, Yan G, Wang X, Min X, Cao L, Zhao Y. | 12/1/2018 |
| the present study described the noncovalent interaction between the E3 ubiquitin ligase RNF8 and SUMO2/3 and indicated that this interaction promoted DSB repair. | Direct binding of RNF8 to SUMO2/3 promotes cell survival following DNA damage.
Liang L, Zhang Z, Li J, Wu J, Wang L, Huang W, Gao S. | 06/30/2018 |
| Data report that RNF8 is overexpressed in highly metastatic breast cell lines and its overexpression can induce EMT in breast cancer cells. Furthermore, RNF8 is aberrantly expressed in invasive breast cancer and positively correlates with lymph node metastasis. | RNF8 promotes epithelial-mesenchymal transition of breast cancer cells.
Kuang J, Li L, Guo L, Su Y, Wang Y, Xu Y, Wang X, Meng S, Lei L, Xu L, Shao G., Free PMC Article | 12/16/2017 |
| The present findings indicate that WRAP53beta and RNF8 are rate-limiting factors in the repair of DNA double-strand breaks and raise the possibility that upregulation of WRAP53beta may contribute to genomic stability in and survival of cancer cells. | Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks.
Rassoolzadeh H, Böhm S, Hedström E, Gad H, Helleday T, Henriksson S, Farnebo M., Free PMC Article | 10/28/2017 |
| The study identifies a previously unrecognized role for RNF8 in the negative regulation of NF-kappaB activation by targeting and deactivating the IKK complex. | RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling.
Gao S, Wu J, Liang L, Xu R. | 09/23/2017 |
| the role of RNF8-mediated histone H3 polyubiquitylation in the regulation of histone H3 stability and chromatin modification, is reported. | RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis.
Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, Lu Z., Free PMC Article | 09/23/2017 |
| RNF8- and Ube2S-dependent Lys11-linkage ubiquitin conjugation plays an important role in regulating DNA damage-induced transcriptional silencing, distinct from the role of Lys63-linkage ubiquitin in the recruitment of DNA damage repair proteins 53BP1 and BRCA1. | RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage.
Paul A, Wang B., Free PMC Article | 09/9/2017 |
| RNF8-promoted Twist ubiquitination is required for Twist localization to the nucleus for subsequent epithelial-mesenchymal transition and cancer stem cells functions, thereby conferring chemoresistance. | The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation.
Lee HJ, Li CF, Ruan D, Powers S, Thompson PA, Frohman MA, Chan CH., Free PMC Article | 09/9/2017 |
| The attenuated DNA damage localization of RNF8 resulting from INT6 depletion could be attributed to the defective retention of ATM. | INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells.
Morris C, Tomimatsu N, Burma S, Jalinot P., Free PMC Article | 08/12/2017 |