| BRSK2 in pancreatic beta cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes. | BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes.
Xu R, Wang K, Yao Z, Zhang Y, Jin L, Pang J, Zhou Y, Wang K, Liu D, Zhang Y, Sun P, Wang F, Chang X, Liu T, Wang S, Zhang Y, Lin S, Hu C, Zhu Y, Han X., Free PMC Article | 01/12/2024 |
| STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway. | STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway.
Zhang C, Wang X, Fang D, Xu P, Mo X, Hu C, Abdelatty A, Wang M, Xu H, Sun Q, Zhou G, She J, Xia J, Hui KM, Xia H., Free PMC Article | 08/21/2021 |
| damaging variation in BRSK2 is a source of neurodevelopmental disease | Deleterious Variation in BRSK2 Associates with a Neurodevelopmental Disorder.
Hiatt SM, Thompson ML, Prokop JW, Lawlor JMJ, Gray DE, Bebin EM, Rinne T, Kempers M, Pfundt R, van Bon BW, Mignot C, Nava C, Depienne C, Kalsner L, Rauch A, Joset P, Bachmann-Gagescu R, Wentzensen IM, McWalter K, Cooper GM., Free PMC Article | 02/8/2020 |
| the intrinsic molecular merit that BRSK2 provides is a survival advantage to PDAC cells and strengthens the invasiveness of these neoplastic cells in energy-deprived environments. | BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity.
Saiyin H, Na N, Han X, Fang Y, Wu Y, Lou W, Yang X., Free PMC Article | 03/31/2018 |
| SAD-A and AMPK kinases are regulators of mTORC1 signaling in the pancreatic beta-cells. | SAD-A and AMPK kinases: the "yin and yang" regulators of mTORC1 signaling in pancreatic β cells.
Nie J, Han X, Shi Y., Free PMC Article | 06/7/2014 |
| BRSK2 interacted with VCP/p97 via three of the four functional domains of VCP/p97. Immunofluorescence demonstrated that BRSK2 and VCP/p97 were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta. | BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation.
Wang Y, Wan B, Zhou J, Li R, Yu L. | 05/31/2014 |
| Anaphase-promoting complex/cyclosome-Cdh1, rather than Cdc20, promotes the degradation of BRSK2 in vivo. | APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.
Li R, Wan B, Zhou J, Wang Y, Luo T, Gu X, Chen F, Yu L., Free PMC Article | 03/9/2013 |
| a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs. | Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells.
Chen XY, Gu XT, Saiyin H, Wan B, Zhang YJ, Li J, Wang YL, Gao R, Wang YF, Dong WP, Najjar SM, Zhang CY, Ding HF, Liu JO, Yu L., Free PMC Article | 11/24/2012 |
| these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis. | BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.
Wang Y, Wan B, Li D, Zhou J, Li R, Bai M, Chen F, Yu L. | 10/27/2012 |
| these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1. | Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.
Zhou J, Wan B, Li R, Gu X, Zhong Z, Wang Y, Yu L. | 09/8/2012 |
| BRSK2 is up-regulated in pancreatic ductal adenocarcinoma. | [Clinical implication of BRSK2 expression in pancreatic ductal adenocarcinoma].
Niu GM, Ji Y, Jin DY, Hou J, Lou WH. | 09/13/2010 |
| STRADalpha.MO25alpha complexes containing LKB1 variants were equally effective at phosphorylating and activating AMPK, BRSK1, and BRSK2 | C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.
Fogarty S, Hardie DG., Free PMC Article | 01/21/2010 |
| level of SAD within neurons is modulated by TORC1 | The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.
Wildonger J, Jan LY, Jan YN., Free PMC Article | 01/21/2010 |
| protein phosphatase 2C is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1/2. | Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.
Bright NJ, Carling D, Thornton C., Free PMC Article | 01/21/2010 |
| BRSK2 may be an autoantigen involved in the pathogenesis of small-cell lung cancer-associated limbic encephalitis. | BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis.
Sabater L, Gómez-Choco M, Saiz A, Graus F. | 01/21/2010 |
| we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. Kinase activity of BRSK2 can be increased through phosphorylation by PKA. | BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.
Guo Z, Tang W, Yuan J, Chen X, Wan B, Gu X, Luo K, Wang Y, Yu L. | 01/21/2010 |