| STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3. | STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3.
Deng L, Cao C, Cai Z, Wang Z, Leng B, Chen Z, Kong F, Zhou Z, He J, Nie X, Bian JS. | 10/9/2024 |
| Protease activated receptor-4: ready to be part of the antithrombosis spectrum. | Protease activated receptor-4: ready to be part of the antithrombosis spectrum.
Andrianova I, Kowalczyk M, Denorme F. | 08/4/2024 |
| The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes. | The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes.
Pelland-St-Pierre L, Pham MC, Nguyen AQH, Pasquet R, Taylor SA, Bosson-Rieutort D, Koushik A, Ho V. | 02/13/2024 |
| The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. | The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.
Denorme F, Armstrong ND, Stoller ML, Portier I, Tugolukova EA, Tanner RM, Montenont E, Bhatlekar S, Cody M, Rustad JL, Ajanel A, Tolley ND, Murray DC, Boyle JL, Nieman MT, McKenzie SE, Yost CC, Lange LA, Cushman M, Irvin MR, Bray PF, Campbell RA., Free PMC Article | 09/19/2023 |
| Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study. | Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study.
Su Q, Shen G, Xu G., Free PMC Article | 05/30/2023 |
| An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay. | An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.
Yang J, Mapelli C, Wang Z, Sum CS, Hua J, Lawrence RM, Ni Y, Seiffert DA. | 08/27/2022 |
| The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population. | The PAR4 Platelet Thrombin Receptor Variant rs773902 does not Impact the Incidence of Thrombotic or Bleeding Events in a Healthy Older Population.
Selvadurai MV, Riaz M, Xie S, Tonkin AM, McNeil JJ, Lacaze P, Hamilton JR. | 08/27/2022 |
| Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice. | Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice.
Renna SA, Michael JV, Kong X, Ma L, Ma P, Nieman MT, Edelstein LC, McKenzie SE. | 04/30/2022 |
| Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function. | Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function.
Corbin LJ, White SJ, Taylor AE, Williams CM, Taylor K, van den Bosch MT, Teasdale JE, Jones M, Bond M, Harper MT, Falk L, Groom A, Hazell GGJ, Paternoster L, Munafò MR, Nordestgaard BG, Tybjærg-Hansen A, Bojesen SE, Relton C, Min JL, Davey Smith G, Mumford AD, Poole AW, Timpson NJ., Free PMC Article | 02/26/2022 |
| Disruption of the biological activity of protease-activated receptors2/4 in adults rather than children in SARS CoV-2 virus-mediated mortality in COVID-19 infection. | Disruption of the biological activity of protease-activated receptors2/4 in adults rather than children in SARS CoV-2 virus-mediated mortality in COVID-19 infection.
Singh Y, Fuloria NK, Fuloria S, Subramaniyan V, Almalki WH, Gupta G, Shaikh MAJ, Singh M, Al-Abbasi FA, Kazmi I., Free PMC Article | 12/18/2021 |
| PAR-4/Ca(2+)-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes. | PAR-4/Ca(2+)-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes.
Giannella A, Ceolotto G, Radu CM, Cattelan A, Iori E, Benetti A, Fabris F, Simioni P, Avogaro A, Vigili de Kreutzenberg S., Free PMC Article | 10/9/2021 |
| Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4). | Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4).
Thibeault PE, LeSarge JC, Arends D, Fernandes M, Chidiac P, Stathopulos PB, Luyt LG, Ramachandran R., Free PMC Article | 10/24/2020 |
| PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1. | PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1.
Guo H, Treude F, Krämer OH, Lüscher B, Hartkamp J., Free PMC Article | 10/24/2020 |
| Increased expression of PAR-1 and -4 could be a contributing component in the mechanisms leading to endofibrosis in high performance athletes. | Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes.
Posthuma JJ, Posma JJN, Schep G, Bender MMH, van Oerle R, van der Wal AC, Ten Cate H, Spronk HMH. | 11/23/2019 |
| Endogenous H2S generated by CBS or CSE caused referred hyperalgesia mediated through MIF in mice with PAR4-induced bladder pain, without causing bladder injury or altering micturition behavior. | Endogenous H(2)S sensitizes PAR4-induced bladder pain.
Wang W, Bo Q, Du J, Yu X, Zhu K, Cui J, Zhao H, Wang Y, Shi B, Zhu Y. | 09/14/2019 |
| This study found divergent and inverse allele frequencies of the PAR4 rs773902 single nucleotide polymorphism (SNP) in the Somali population compared with data previously reported for blacks in the United States. The A allele frequency of the PAR4 rs773902 SNP in Somalis was 38% compared with the previously reported 63% for blacks. | Frequency of PAR4 Ala120Thr variant associated with platelet reactivity significantly varies across sub-Saharan African populations.
Heenkenda MK, Lindahl TL, Osman A., Free PMC Article | 08/3/2019 |
| The signaling difference by the PAR4-120 variant results in the enhancement of both Gq and G13 activation and an increase in thrombus formation resulting in a potential resistance to traditional antiplatelet therapies targeting COX-1 and the P2Y12 receptor. | Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.
Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M., Free PMC Article | 07/20/2019 |
| methylation of F2RL3 can affect the prognosis of different types of acute coronary syndrome and is closely related to mortality | Correlation of hypertension and F2RL3 gene methylation with Prognosis of coronary heart disease.
Gao BF, Shen ZC, Bian WS, Wu SX, Kang ZX, Gao Y. | 06/15/2019 |
| lower major bleeding rates were observed in the overall TRACER cohort with the hyperreactive PAR4 Thr120 variant | Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: Analysis from the TRACER trial.
Tricoci P, Neely M, Whitley MJ, Edelstein LC, Simon LM, Shaw C, Fortina P, Moliterno DJ, Armstrong PW, Aylward P, White H, Van de Werf F, Jennings LK, Wallentin L, Held C, Harrington RA, Mahaffey KW, Bray PF., Free PMC Article | 04/27/2019 |
| Allergen Der p3 from house dust mites activates store-operated calcium channels and protease-activated 4 receptors, stimulating mast cell migration. | The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca(2+) Channels and Mast Cell Migration through PAR4 Receptors.
Lin YP, Nelson C, Kramer H, Parekh AB. | 02/9/2019 |
| Creosote-exposed workers (73.3%), but not chimney sweeps (76.6%) had lower methylation of F2RL3 cg03636183 than controls (76.7%). | DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons.
Alhamdow A, Lindh C, Hagberg J, Graff P, Westberg H, Krais AM, Albin M, Gustavsson P, Tinnerberg H, Broberg K., Free PMC Article | 02/2/2019 |
| Data suggested that PAR4-AP-induced platelet reactivity between PAR4 rs773902 was associated with altered intensity of Ca(2+) mobilization and ERK activation. | Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca(2+) mobilization and ERK phosphorylation in healthy Japanese subjects.
Morikawa Y, Kato H, Kashiwagi H, Nishiura N, Akuta K, Honda S, Kanakura Y, Tomiyama Y. | 09/15/2018 |
| Thrombin binding to extra-cellular loop II (ECLII) of PAR4 is important for its cleavage and activation of PAR4. | A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets.
Sánchez Centellas D, Gudlur S, Vicente-Carrillo A, Ramström S, Lindahl TL. | 03/17/2018 |
| PAR4 has a role in mediating platelet aggregation; its blockade provides antithrombotic activity | Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.
Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J. | 02/3/2018 |
| PAR4 is required for platelet procoagulant function during thrombus formation in human blood | Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood.
French SL, Arthur JF, Lee H, Nesbitt WS, Andrews RK, Gardiner EE, Hamilton JR. | 01/6/2018 |