| NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis. | NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis.
Gu W, Li C, Shen T, Tong L, Yuan W, Zheng X, Wang T, Wang S, Zhu B, Zhang C, Zhang C., Free PMC Article | 07/30/2024 |
| Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells. | Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells.
Hong KU, Tagnedji AH, Doll MA, Walls KM, Hein DW., Free PMC Article | 07/20/2023 |
| Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study. | Altered Arylamine N-acetyltransferase 1 and miR-1290 Levels in Childhood Acute Lymphoblastic Leukemia: A Pilot Study.
Hernandez-Gonzalez O, Del Carmen Milan-Segovia R, Zavala-Reyes D, Alvarado-Zamarripa DM, Ortiz-Zamudio JJ, Correa-Gonzalez LC, Vargas-Morales JM, Uresti-Rivera EE, Portales-Perez DP., Free PMC Article | 05/8/2023 |
| Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis. | Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis.
McAleese CE, Butcher NJ, Minchin RF., Free PMC Article | 09/24/2022 |
| Polymorphism in the human arylamine N-acetyltransferase 1 gene 3'-untranslated region determines polyadenylation signal usage. | Polymorphism in the human arylamine N-acetyltransferase 1 gene 3'-untranslated region determines polyadenylation signal usage.
Choudhury C, Butcher NJ, Minchin RF. | 05/21/2022 |
| Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis. | Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis.
Doll MA, Ray AR, Salazar-González RA, Shah PP, Vega AA, Sears SM, Krueger AM, Hong KU, Beverly LJ, Hein DW., Free PMC Article | 04/30/2022 |
| NAT1 is a critical prognostic biomarker and inhibits proliferation of colorectal cancer through modulation of PI3K/Akt/mTOR. | NAT1 is a critical prognostic biomarker and inhibits proliferation of colorectal cancer through modulation of PI3K/Akt/mTOR.
Cai J, Sun H, Chen L, Xie M, Zhuang J, Gao L, Wei XX. | 12/11/2021 |
| NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure. | NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure.
Brooks CC, Martin LJ, Pilipenko V, He H, LeMasters GK, Lockey JE, Bernstein DI, Ryan PH, Khurana Hershey GK, Biagini Myers JM., Free PMC Article | 09/25/2021 |
| MicroRNA-6744-5p promotes anoikis in breast cancer and directly targets NAT1 enzyme. | MicroRNA-6744-5p promotes anoikis in breast cancer and directly targets NAT1 enzyme.
Malagobadan S, Ho CS, Nagoor NH., Free PMC Article | 09/11/2021 |
| Effect arylamine N-acetyltransferase 1 on morphology, adhesion, migration, and invasion of MDA-MB-231 cells: role of matrix metalloproteinases and integrin alphaV. | Effect arylamine N-acetyltransferase 1 on morphology, adhesion, migration, and invasion of MDA-MB-231 cells: role of matrix metalloproteinases and integrin αV.
Li P, Butcher NJ, Minchin RF., Free PMC Article | 06/5/2021 |
| CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism. | CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism.
Carlisle SM, Trainor PJ, Hong KU, Doll MA, Hein DW., Free PMC Article | 12/19/2020 |
| Slow N-acetylation as a possible contributor to bladder carcinogenesis. | Slow N-acetylation as a possible contributor to bladder carcinogenesis.
El Kawak M, Dhaini HR, Jabbour ME, Moussa MA, El Asmar K, Aoun M. | 11/21/2020 |
| The expression of NAT1 was found to be negatively correlated with MMP9 expression in tumor tissue from breast cancer patients. | Arylamine N-Acetyltransferase 1 Regulates Expression of Matrix Metalloproteinase 9 in Breast Cancer Cells: Role of Hypoxia-Inducible Factor 1-α.
Li P, Butcher NJ, Minchin RF. | 03/7/2020 |
| Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex | Loss of human arylamine N-acetyltransferase I regulates mitochondrial function by inhibition of the pyruvate dehydrogenase complex.
Wang L, Minchin RF, Essebier PJ, Butcher NJ. | 01/11/2020 |
| We propose that phenotypic designations as 'rapid' and 'slow' acetylator should be discontinued for NAT1 alleles, although these designations remain very appropriate for NAT2 alleles. | Functional expression of human arylamine N-acetyltransferase NAT1*10 and NAT1*11 alleles: a mini review.
Hein DW, Fakis G, Boukouvala S., Free PMC Article | 06/1/2019 |
| we have observed that differences in NAT1 activity, particularly the knockout of NAT1, significantly alters the bioenergetics profile of MDA-MB-231 triple negative breast cancer cells. | Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity.
Carlisle SM, Trainor PJ, Doll MA, Stepp MW, Klinge CM, Hein DW., Free PMC Article | 05/11/2019 |
| multiple populations in breast cancer can be segregated based on NAT1 mRNA levels; for patients with low expression, overall survival is significantly less than for patients with intermediate or high expression; low NAT1 expression shows a distinct poor response to chemotherapy | Trimodal distribution of arylamine N-acetyltransferase 1 mRNA in breast cancer tumors: association with overall survival and drug resistance.
Minchin RF, Butcher NJ., Free PMC Article | 02/9/2019 |
| Results indicate that haplotypes that provide rapid N-acetyltransferase 1 (NAT1) and slow N-acetyltransferase 2 (NAT2) acetylating phenotypes may influence the development of acute lymphoblastic leukemia (ALL) in children. | Genetic polymorphisms of arylamine N-acetyltransferases 1 and 2 and the likelihood of developing pediatric acute lymphoblastic leukemia.
Hernández-González O, Ortiz-Zamudio JJ, Rodríguez-Pinal CJ, Alvarado-Morales I, Martínez-Jiménez VDC, Salazar-González RA, Correa-González LC, Gómez R, Portales-Pérez DP, Milán-Segovia RDC. | 02/9/2019 |
| NAT1-catalyzed N-acetylation in peripheral blood mononuclear cells is higher in T cell than in other immune cell subtypes and that individual variation in N-acetylation capacity is dependent upon NATb mRNA and NAT1 haplotype. | Arylamine N-acetyltransferase 1 in situ N-acetylation on CD3+ peripheral blood mononuclear cells correlate with NATb mRNA and NAT1 haplotype.
Salazar-González RA, Turiján-Espinoza E, Hein DW, Niño-Moreno PC, Romano-Moreno S, Milán-Segovia RC, Portales-Pérez DP. | 01/19/2019 |
| Data showed that NAT1, NAT2, and ESR1 expression were increased in primary breast tumor tissue and that NAT1 expression was much higher than NAT2. NAT1 and ESR1 expression were strongly associated, whereas NAT2 and ESR1 expression were not. Although NAT1 and NAT2 expression were associated, the magnitude was moderate. | Retrospective analysis of estrogen receptor 1 and N‑acetyltransferase gene expression in normal breast tissue, primary breast tumors, and established breast cancer cell lines.
Carlisle SM, Hein DW., Free PMC Article | 11/3/2018 |
| the results suggested that there was no association between NAT1*10 allele and bladder cancer risk (meta-analysis). | Association of N-acetyltransferase 1 polymorphism and bladder cancer risk: an updated meta-analysis and trial sequential analysis.
Xu Z, Li X, Qin Z, Xue J, Wang J, Liu Z, Cai H, Yu B, Xu T, Zou Q. | 06/23/2018 |
| identified a novel endogenous role for human NAT1 that might explain some of its effects in cancer cell growth and survival | Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway.
Witham KL, Minchin RF, Butcher NJ. | 05/13/2017 |
| N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes. | N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.
Cocco P, Zucca M, Sanna S, Satta G, Nonne T, Angelucci E, Gabbas A, Rais M, Malpeli G, Campagna M, Scarpa A, G Ennas M. | 01/28/2017 |
| The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR c.677C>T p.A222V(rs1801133), TP53 c.215C>G p.R72P (rs1042522), NQO1 c.559C>T p.P187S (rs1800566), and NAT1 alleles imputed as fast acetylator genotypes. [meta-analysis] | Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.
Montazeri Z, Theodoratou E, Nyiraneza C, Timofeeva M, Chen W, Svinti V, Sivakumaran S, Gresham G, Cubitt L, Carvajal-Carmona L, Bertagnolli MM, Zauber AG, Tomlinson I, Farrington SM, Dunlop MG, Campbell H, Little J., Free PMC Article | 12/31/2016 |
| The rs1799931(G>A) genotype was detected in the control population but not in the T2DM population. The wild type (G) allele frequency was higher in T2DM than controls. The mutant allele (A) in rs1799931(G>A) had a protective effect for T2DM. | N-acetyltransferase 1 and 2 polymorphisms and risk of diabetes mellitus type 2 in a Saudi population.
Al-Shaqha WM, Alkharfy KM, Al-Daghri NM, Mohammed AK., Free PMC Article | 07/2/2016 |